FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer
Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of mole...
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| Veröffentlicht in: | Cancer letters 2019-07, Vol.455, p.14-25 |
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| container_title | Cancer letters |
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| creator | Shen, Yamei Lv, Wei Yang, Hengli Cai, Wenbin Zhao, Ping Zhang, Li Zhang, Jian Yuan, Lijun Duan, Yunyou |
| description | Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of molecule-targeted ultrasound contrast agents (UCAs) with excellent performance is urgently needed. In this study, we synthetized folic acid and IR-780 on self-made nanobubbles and prepared novel UCAs, named FA-NBs-IR780. The results showed that the conjugates had a uniform size distribution (591 ± 52 nm). In vitro and in vivo experiments demonstrated that FA-NBs-IR780 can target tumour cells via dual molecular targeting, perform enhanced-contrast ultrasound imaging and near-infrared fluorescence (NIRF) imaging for the precise detection of tumours, and induce targeted photothermal therapy in lesions irradiated at 808 nm. Ex vivo experiments further confirmed that FA-NBs-IR780 efficiently induced tumour cell apoptosis and inhibited tumour growth. The newly fabricated FA-NBs-IR780 were observed to be molecule-targeted dual-mode UCAs and may have potential applications in early accurate diagnosis and targeted therapy of cancer in the future.
•FA-NBs-IR780 is a novel molecule-targeted ultrasound contrast agentfor accurate diagnosis and targeted therapyof cancer.•FA-NBs-IR780 can extremely target cancer via enhanced molecular targeting.•FA-NBs-IR780 allowing for the ultrasound/NIRF dual-mode imaging of cancer.•Irradiated by NIR, IR-780 could cause striking photothermal responsiveness in lesions by the help of FA-NBs-IR780. |
| doi_str_mv | 10.1016/j.canlet.2019.04.023 |
| format | Article |
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•FA-NBs-IR780 is a novel molecule-targeted ultrasound contrast agentfor accurate diagnosis and targeted therapyof cancer.•FA-NBs-IR780 can extremely target cancer via enhanced molecular targeting.•FA-NBs-IR780 allowing for the ultrasound/NIRF dual-mode imaging of cancer.•Irradiated by NIR, IR-780 could cause striking photothermal responsiveness in lesions by the help of FA-NBs-IR780.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2019.04.023</identifier><identifier>PMID: 31018151</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acoustics ; Animals ; Apoptosis ; Brain cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - metabolism ; Breast Neoplasms - therapy ; Cancer ; Cancer therapies ; Cell Line, Tumor ; Contrast agents ; Contrast media ; Contrast Media - administration & dosage ; Contrast Media - chemistry ; Contrast Media - pharmacokinetics ; Diagnosis ; Female ; Fluorescence ; Folic acid ; Glioblastoma - diagnostic imaging ; Glioblastoma - metabolism ; Glioblastoma - therapy ; Humans ; Hydration ; Indoles - administration & dosage ; Indoles - chemistry ; Indoles - pharmacokinetics ; Infrared imaging ; Lasers ; Lesions ; Ligands ; Lipids ; Medical diagnosis ; Medical imaging ; Medical prognosis ; Medical research ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microbubbles ; Molecule imaging ; Nanobubbles ; Nanocapsules - administration & dosage ; Nanocapsules - chemistry ; Near-infrared fluorescence ; NMR ; Nuclear magnetic resonance ; Phototherapy - methods ; Photothermal therapy ; Polyethylene glycol ; Random Allocation ; Size distribution ; Tissue Distribution ; Tumors ; Ultrasonic imaging ; Ultrasonography ; Ultrasonography - methods ; Ultrasound ; Xenograft Model Antitumor Assays</subject><ispartof>Cancer letters, 2019-07, Vol.455, p.14-25</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier B.V.</rights><rights>Copyright Elsevier Limited Jul 28, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-8af4038b1e877c538b531b5f8fb2126f7c814d13778c4234166a61c9501448823</citedby><cites>FETCH-LOGICAL-c390t-8af4038b1e877c538b531b5f8fb2126f7c814d13778c4234166a61c9501448823</cites><orcidid>0000-0003-0769-8328</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030438351930254X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31018151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Yamei</creatorcontrib><creatorcontrib>Lv, Wei</creatorcontrib><creatorcontrib>Yang, Hengli</creatorcontrib><creatorcontrib>Cai, Wenbin</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Yuan, Lijun</creatorcontrib><creatorcontrib>Duan, Yunyou</creatorcontrib><title>FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of molecule-targeted ultrasound contrast agents (UCAs) with excellent performance is urgently needed. In this study, we synthetized folic acid and IR-780 on self-made nanobubbles and prepared novel UCAs, named FA-NBs-IR780. The results showed that the conjugates had a uniform size distribution (591 ± 52 nm). In vitro and in vivo experiments demonstrated that FA-NBs-IR780 can target tumour cells via dual molecular targeting, perform enhanced-contrast ultrasound imaging and near-infrared fluorescence (NIRF) imaging for the precise detection of tumours, and induce targeted photothermal therapy in lesions irradiated at 808 nm. Ex vivo experiments further confirmed that FA-NBs-IR780 efficiently induced tumour cell apoptosis and inhibited tumour growth. The newly fabricated FA-NBs-IR780 were observed to be molecule-targeted dual-mode UCAs and may have potential applications in early accurate diagnosis and targeted therapy of cancer in the future.
•FA-NBs-IR780 is a novel molecule-targeted ultrasound contrast agentfor accurate diagnosis and targeted therapyof cancer.•FA-NBs-IR780 can extremely target cancer via enhanced molecular targeting.•FA-NBs-IR780 allowing for the ultrasound/NIRF dual-mode imaging of cancer.•Irradiated by NIR, IR-780 could cause striking photothermal responsiveness in lesions by the help of FA-NBs-IR780.</description><subject>Acoustics</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Brain cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Contrast agents</subject><subject>Contrast media</subject><subject>Contrast Media - administration & dosage</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Folic acid</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - therapy</subject><subject>Humans</subject><subject>Hydration</subject><subject>Indoles - administration & dosage</subject><subject>Indoles - chemistry</subject><subject>Indoles - pharmacokinetics</subject><subject>Infrared imaging</subject><subject>Lasers</subject><subject>Lesions</subject><subject>Ligands</subject><subject>Lipids</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Microbubbles</subject><subject>Molecule imaging</subject><subject>Nanobubbles</subject><subject>Nanocapsules - administration & dosage</subject><subject>Nanocapsules - chemistry</subject><subject>Near-infrared fluorescence</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phototherapy - methods</subject><subject>Photothermal therapy</subject><subject>Polyethylene glycol</subject><subject>Random Allocation</subject><subject>Size distribution</subject><subject>Tissue Distribution</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi0EotPCGyBkiQ2bBN8ydlgglaqFSlWREKwtxzmZepTYgy-V-ii8LQ5TWLBgdc7i83fk_0foFSUtJXT7bt9a42fILSO0b4loCeNP0IYqyRrZK_IUbQgnouGKdyfoNKU9IaQTsnuOTng1KNrRDfp5dd7cfkzN9VepyHt8G-5hxkuZs5uKt9kFb2bsjQ9DGYYZEjYJL2EGW2Zosok7yDDiykeTQvEjtsGve8ZmBz4nPIWIjbUlmgx4dGbnQ3JVU9HDXcgh30Fc6o11msMDDhOu_7IQX6Bnk5kTvHycZ-j71eW3i8_NzZdP1xfnN43lPcmNMpMgXA0UlJS2q1vH6dBNahoYZdtJWkXFSLmUygrGBd1uzZbaviNUCKUYP0Nvj95DDD8KpKwXlyzMs_EQStKM0cpKxnhF3_yD7kOJNaGVYqzrRU9FpcSRsjGkFGHSh-gWEx80JXqtTu_1sTq9VqeJ0OS3_PWjvAwLjH8f_emqAh-OANQ07h1EnayDGtXoItisx-D-f-EXErKshQ</recordid><startdate>20190728</startdate><enddate>20190728</enddate><creator>Shen, Yamei</creator><creator>Lv, Wei</creator><creator>Yang, Hengli</creator><creator>Cai, Wenbin</creator><creator>Zhao, Ping</creator><creator>Zhang, Li</creator><creator>Zhang, Jian</creator><creator>Yuan, Lijun</creator><creator>Duan, Yunyou</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0769-8328</orcidid></search><sort><creationdate>20190728</creationdate><title>FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer</title><author>Shen, Yamei ; Lv, Wei ; Yang, Hengli ; Cai, Wenbin ; Zhao, Ping ; Zhang, Li ; Zhang, Jian ; Yuan, Lijun ; Duan, Yunyou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-8af4038b1e877c538b531b5f8fb2126f7c814d13778c4234166a61c9501448823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acoustics</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Brain cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Contrast agents</topic><topic>Contrast media</topic><topic>Contrast Media - administration & dosage</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Folic acid</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - therapy</topic><topic>Humans</topic><topic>Hydration</topic><topic>Indoles - administration & dosage</topic><topic>Indoles - chemistry</topic><topic>Indoles - pharmacokinetics</topic><topic>Infrared imaging</topic><topic>Lasers</topic><topic>Lesions</topic><topic>Ligands</topic><topic>Lipids</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Microbubbles</topic><topic>Molecule imaging</topic><topic>Nanobubbles</topic><topic>Nanocapsules - administration & dosage</topic><topic>Nanocapsules - chemistry</topic><topic>Near-infrared fluorescence</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phototherapy - methods</topic><topic>Photothermal therapy</topic><topic>Polyethylene glycol</topic><topic>Random Allocation</topic><topic>Size distribution</topic><topic>Tissue Distribution</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Yamei</creatorcontrib><creatorcontrib>Lv, Wei</creatorcontrib><creatorcontrib>Yang, Hengli</creatorcontrib><creatorcontrib>Cai, Wenbin</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Yuan, Lijun</creatorcontrib><creatorcontrib>Duan, Yunyou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Yamei</au><au>Lv, Wei</au><au>Yang, Hengli</au><au>Cai, Wenbin</au><au>Zhao, Ping</au><au>Zhang, Li</au><au>Zhang, Jian</au><au>Yuan, Lijun</au><au>Duan, Yunyou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2019-07-28</date><risdate>2019</risdate><volume>455</volume><spage>14</spage><epage>25</epage><pages>14-25</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of molecule-targeted ultrasound contrast agents (UCAs) with excellent performance is urgently needed. In this study, we synthetized folic acid and IR-780 on self-made nanobubbles and prepared novel UCAs, named FA-NBs-IR780. The results showed that the conjugates had a uniform size distribution (591 ± 52 nm). In vitro and in vivo experiments demonstrated that FA-NBs-IR780 can target tumour cells via dual molecular targeting, perform enhanced-contrast ultrasound imaging and near-infrared fluorescence (NIRF) imaging for the precise detection of tumours, and induce targeted photothermal therapy in lesions irradiated at 808 nm. Ex vivo experiments further confirmed that FA-NBs-IR780 efficiently induced tumour cell apoptosis and inhibited tumour growth. The newly fabricated FA-NBs-IR780 were observed to be molecule-targeted dual-mode UCAs and may have potential applications in early accurate diagnosis and targeted therapy of cancer in the future.
•FA-NBs-IR780 is a novel molecule-targeted ultrasound contrast agentfor accurate diagnosis and targeted therapyof cancer.•FA-NBs-IR780 can extremely target cancer via enhanced molecular targeting.•FA-NBs-IR780 allowing for the ultrasound/NIRF dual-mode imaging of cancer.•Irradiated by NIR, IR-780 could cause striking photothermal responsiveness in lesions by the help of FA-NBs-IR780.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31018151</pmid><doi>10.1016/j.canlet.2019.04.023</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0769-8328</orcidid></addata></record> |
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| subjects | Acoustics Animals Apoptosis Brain cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Breast Neoplasms - therapy Cancer Cancer therapies Cell Line, Tumor Contrast agents Contrast media Contrast Media - administration & dosage Contrast Media - chemistry Contrast Media - pharmacokinetics Diagnosis Female Fluorescence Folic acid Glioblastoma - diagnostic imaging Glioblastoma - metabolism Glioblastoma - therapy Humans Hydration Indoles - administration & dosage Indoles - chemistry Indoles - pharmacokinetics Infrared imaging Lasers Lesions Ligands Lipids Medical diagnosis Medical imaging Medical prognosis Medical research Mice Mice, Inbred BALB C Mice, Nude Microbubbles Molecule imaging Nanobubbles Nanocapsules - administration & dosage Nanocapsules - chemistry Near-infrared fluorescence NMR Nuclear magnetic resonance Phototherapy - methods Photothermal therapy Polyethylene glycol Random Allocation Size distribution Tissue Distribution Tumors Ultrasonic imaging Ultrasonography Ultrasonography - methods Ultrasound Xenograft Model Antitumor Assays |
| title | FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer |
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