The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials
Objective Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among pati...
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| Veröffentlicht in: | Inflammopharmacology 2019-04, Vol.27 (2), p.233-248 |
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| creator | Jorat, Mohammad Vahid Tabrizi, Reza Kolahdooz, Fariba Akbari, Maryam Salami, Maryamalsadat Heydari, Seyed Taghi Asemi, Zatollah |
| description | Objective
Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.
Methods
The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and
Q
and
I
2
tests, respectively. Given the presence of heterogeneity, random-effects model or fixed-effect model were used to pool standardized mean differences (SMDs) as summary effect sizes.
Results
A total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09,
P
|
| doi_str_mv | 10.1007/s10787-019-00572-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2215004307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2215004307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-622beba3886f1c5a9773b230c6c7164e89d081e5dd17f1c44fbfd610ca8ebd023</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi0EoqeFF2CBvGSTMnYSO2GHKm5SJYRU1pHjTIpLYh88TnvSB-S5cE8KSyRL48s3n6X5GXsl4FwA6LckQDe6ANEWALWWxeEJ24laNUWtoHnKdtDKuqhUK0_YKdENACit2ufspARdN6qtd-z31Q_kOI5oE_EwchvQ368z8m8COC37_YQz-mSSC57n1bswm_gT45F2fpzMPG-vxg88HNyQT7fIKUUkygQ3c_DXWRyDN3HlJibMZXCEhvAdN5xWSvggsTzircO7o2rGZArjzbSSO34W822Y3T0OWeZTDNOUtyk6M9EL9mzMBV8-1jP2_eOHq4vPxeXXT18u3l8Wtqx0KpSUPfambBo1ClubVuuylyVYZbVQFTbtAI3AehiEzkBVjf04KAHWNNgPIMsz9mbz7mP4tSClbnZkcZqMx7BQJ6WoAao834zKDbUxEEUcu310eXZrJ6B7yK_b8utyft0xv-6Qm14_-pd-xuFfy9_AMlBuAOUnf42xuwlLzFOi_2n_AHZXrNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2215004307</pqid></control><display><type>article</type><title>The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jorat, Mohammad Vahid ; Tabrizi, Reza ; Kolahdooz, Fariba ; Akbari, Maryam ; Salami, Maryamalsadat ; Heydari, Seyed Taghi ; Asemi, Zatollah</creator><creatorcontrib>Jorat, Mohammad Vahid ; Tabrizi, Reza ; Kolahdooz, Fariba ; Akbari, Maryam ; Salami, Maryamalsadat ; Heydari, Seyed Taghi ; Asemi, Zatollah</creatorcontrib><description>Objective
Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.
Methods
The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and
Q
and
I
2
tests, respectively. Given the presence of heterogeneity, random-effects model or fixed-effect model were used to pool standardized mean differences (SMDs) as summary effect sizes.
Results
A total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09,
P
< 0.001;
I
2
= 94.5%) and catalase (CAT) levels (SMD 1.00; 95% CI, 0.57, 1.43,
P
< 0.001;
I
2
= 24.5%), and significantly reduced malondialdehyde (MDA) (SMD − 4.29; 95% CI − 6.72, − 1.86,
P
= 0.001;
I
2
= 97.6%) and diene levels (SMD − 2.40; 95% CI − 3.11, − 1.68,
P
< 0.001;
I
2
= 72.6%). We did not observe any significant effect of CoQ10 supplementation on C-reactive protein (CRP) (SMD − 0.62; 95% CI − 1.31, 0.08,
P
= 0.08;
I
2
= 87.9%), tumor necrosis factor alpha (TNF-α) (SMD 0.22; 95% CI − 1.07, 1.51,
P
= 0.73;
I
2
= 89.7%), interleukin-6 (IL-6) (SMD − 1.63; 95% CI − 3.43, 0.17,
P
= 0.07;
I
2
= 95.2%), and glutathione peroxidase (GPx) levels (SMD 0.14; 95% CI − 0.77, 1.04,
P
= 0.76;
I
2
= 78.7%).
Conclusions
Overall, this meta-analysis demonstrated CoQ10 supplementation increased SOD and CAT, and decreased MDA and diene levels, but did not affect CRP, TNF-α, IL-6, and GPx levels among patients with CAD.</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-019-00572-x</identifier><identifier>PMID: 30758695</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Animals ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Coronary Artery Disease - metabolism ; Dermatology ; Dietary Supplements ; Gastroenterology ; Humans ; Immunology ; Inflammation - metabolism ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Randomized Controlled Trials as Topic ; Review Article ; Rheumatology ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology</subject><ispartof>Inflammopharmacology, 2019-04, Vol.27 (2), p.233-248</ispartof><rights>Springer Nature Switzerland AG 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-622beba3886f1c5a9773b230c6c7164e89d081e5dd17f1c44fbfd610ca8ebd023</citedby><cites>FETCH-LOGICAL-c347t-622beba3886f1c5a9773b230c6c7164e89d081e5dd17f1c44fbfd610ca8ebd023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10787-019-00572-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10787-019-00572-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30758695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jorat, Mohammad Vahid</creatorcontrib><creatorcontrib>Tabrizi, Reza</creatorcontrib><creatorcontrib>Kolahdooz, Fariba</creatorcontrib><creatorcontrib>Akbari, Maryam</creatorcontrib><creatorcontrib>Salami, Maryamalsadat</creatorcontrib><creatorcontrib>Heydari, Seyed Taghi</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><title>The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>Objective
Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.
Methods
The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and
Q
and
I
2
tests, respectively. Given the presence of heterogeneity, random-effects model or fixed-effect model were used to pool standardized mean differences (SMDs) as summary effect sizes.
Results
A total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09,
P
< 0.001;
I
2
= 94.5%) and catalase (CAT) levels (SMD 1.00; 95% CI, 0.57, 1.43,
P
< 0.001;
I
2
= 24.5%), and significantly reduced malondialdehyde (MDA) (SMD − 4.29; 95% CI − 6.72, − 1.86,
P
= 0.001;
I
2
= 97.6%) and diene levels (SMD − 2.40; 95% CI − 3.11, − 1.68,
P
< 0.001;
I
2
= 72.6%). We did not observe any significant effect of CoQ10 supplementation on C-reactive protein (CRP) (SMD − 0.62; 95% CI − 1.31, 0.08,
P
= 0.08;
I
2
= 87.9%), tumor necrosis factor alpha (TNF-α) (SMD 0.22; 95% CI − 1.07, 1.51,
P
= 0.73;
I
2
= 89.7%), interleukin-6 (IL-6) (SMD − 1.63; 95% CI − 3.43, 0.17,
P
= 0.07;
I
2
= 95.2%), and glutathione peroxidase (GPx) levels (SMD 0.14; 95% CI − 0.77, 1.04,
P
= 0.76;
I
2
= 78.7%).
Conclusions
Overall, this meta-analysis demonstrated CoQ10 supplementation increased SOD and CAT, and decreased MDA and diene levels, but did not affect CRP, TNF-α, IL-6, and GPx levels among patients with CAD.</description><subject>Allergology</subject><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Dermatology</subject><subject>Dietary Supplements</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology/Toxicology</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review Article</subject><subject>Rheumatology</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhi0EoqeFF2CBvGSTMnYSO2GHKm5SJYRU1pHjTIpLYh88TnvSB-S5cE8KSyRL48s3n6X5GXsl4FwA6LckQDe6ANEWALWWxeEJ24laNUWtoHnKdtDKuqhUK0_YKdENACit2ufspARdN6qtd-z31Q_kOI5oE_EwchvQ368z8m8COC37_YQz-mSSC57n1bswm_gT45F2fpzMPG-vxg88HNyQT7fIKUUkygQ3c_DXWRyDN3HlJibMZXCEhvAdN5xWSvggsTzircO7o2rGZArjzbSSO34W822Y3T0OWeZTDNOUtyk6M9EL9mzMBV8-1jP2_eOHq4vPxeXXT18u3l8Wtqx0KpSUPfambBo1ClubVuuylyVYZbVQFTbtAI3AehiEzkBVjf04KAHWNNgPIMsz9mbz7mP4tSClbnZkcZqMx7BQJ6WoAao834zKDbUxEEUcu310eXZrJ6B7yK_b8utyft0xv-6Qm14_-pd-xuFfy9_AMlBuAOUnf42xuwlLzFOi_2n_AHZXrNA</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Jorat, Mohammad Vahid</creator><creator>Tabrizi, Reza</creator><creator>Kolahdooz, Fariba</creator><creator>Akbari, Maryam</creator><creator>Salami, Maryamalsadat</creator><creator>Heydari, Seyed Taghi</creator><creator>Asemi, Zatollah</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials</title><author>Jorat, Mohammad Vahid ; Tabrizi, Reza ; Kolahdooz, Fariba ; Akbari, Maryam ; Salami, Maryamalsadat ; Heydari, Seyed Taghi ; Asemi, Zatollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-622beba3886f1c5a9773b230c6c7164e89d081e5dd17f1c44fbfd610ca8ebd023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Dermatology</topic><topic>Dietary Supplements</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology/Toxicology</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review Article</topic><topic>Rheumatology</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jorat, Mohammad Vahid</creatorcontrib><creatorcontrib>Tabrizi, Reza</creatorcontrib><creatorcontrib>Kolahdooz, Fariba</creatorcontrib><creatorcontrib>Akbari, Maryam</creatorcontrib><creatorcontrib>Salami, Maryamalsadat</creatorcontrib><creatorcontrib>Heydari, Seyed Taghi</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jorat, Mohammad Vahid</au><au>Tabrizi, Reza</au><au>Kolahdooz, Fariba</au><au>Akbari, Maryam</au><au>Salami, Maryamalsadat</au><au>Heydari, Seyed Taghi</au><au>Asemi, Zatollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>27</volume><issue>2</issue><spage>233</spage><epage>248</epage><pages>233-248</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract>Objective
Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.
Methods
The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and
Q
and
I
2
tests, respectively. Given the presence of heterogeneity, random-effects model or fixed-effect model were used to pool standardized mean differences (SMDs) as summary effect sizes.
Results
A total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09,
P
< 0.001;
I
2
= 94.5%) and catalase (CAT) levels (SMD 1.00; 95% CI, 0.57, 1.43,
P
< 0.001;
I
2
= 24.5%), and significantly reduced malondialdehyde (MDA) (SMD − 4.29; 95% CI − 6.72, − 1.86,
P
= 0.001;
I
2
= 97.6%) and diene levels (SMD − 2.40; 95% CI − 3.11, − 1.68,
P
< 0.001;
I
2
= 72.6%). We did not observe any significant effect of CoQ10 supplementation on C-reactive protein (CRP) (SMD − 0.62; 95% CI − 1.31, 0.08,
P
= 0.08;
I
2
= 87.9%), tumor necrosis factor alpha (TNF-α) (SMD 0.22; 95% CI − 1.07, 1.51,
P
= 0.73;
I
2
= 89.7%), interleukin-6 (IL-6) (SMD − 1.63; 95% CI − 3.43, 0.17,
P
= 0.07;
I
2
= 95.2%), and glutathione peroxidase (GPx) levels (SMD 0.14; 95% CI − 0.77, 1.04,
P
= 0.76;
I
2
= 78.7%).
Conclusions
Overall, this meta-analysis demonstrated CoQ10 supplementation increased SOD and CAT, and decreased MDA and diene levels, but did not affect CRP, TNF-α, IL-6, and GPx levels among patients with CAD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30758695</pmid><doi>10.1007/s10787-019-00572-x</doi><tpages>16</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Allergology Animals Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Coronary Artery Disease - metabolism Dermatology Dietary Supplements Gastroenterology Humans Immunology Inflammation - metabolism Oxidative Stress - drug effects Pharmacology/Toxicology Randomized Controlled Trials as Topic Review Article Rheumatology Ubiquinone - analogs & derivatives Ubiquinone - pharmacology |
| title | The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials |
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