Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury
The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO 2 removal while potentially reducing the risk of ventilator-induced lung injury. Objective To demonstrate that the use of very lo...
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| Veröffentlicht in: | Journal of perinatology 2019-05, Vol.39 (5), p.730-736 |
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| creator | González-Pacheco, Noelia Sánchez-Luna, Manuel Chimenti-Camacho, Paz Santos-González, Martín Palau-Concejo, Paula Tendillo-Cortijo, Francisco |
| description | The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO
2
removal while potentially reducing the risk of ventilator-induced lung injury.
Objective
To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.
Study design
Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO
2
). After 12 h of mechanical ventilation, the pulmonary histologic pattern was analyzed.
Results
We found in the 10 Hz group with the higher VThf compared with the 20 Hz and very low VThf group more evident and more severe histological lesions with inflammatory infiltrate within the alveolar wall and alveolar space, as well as large areas of parenchyma consolidation and areas of alveolar hemorrhage in the more severe cases.
Conclusion
The use of very low VThf compared with higher VThf at similar CO
2
removal reduces lung injury in a neonatal animal model of lung injury after prolonged mechanical ventilation with HFOV combined with VG. |
| doi_str_mv | 10.1038/s41372-019-0338-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2215002113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2215002113</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-75b7e1bbf8462b73ba40aec37b744bf25684f58ca5e8cf01bc2efdf2d46312333</originalsourceid><addsrcrecordid>eNp1kM1qGzEURkVJqJ2kD9BNEGTTjZqrv5G8LCFtA4Zumm3ESCMlY8YjVxo5-O2rwUkKhawEV-f77uUg9JnCVwpcX2dBuWIE6IoA55rID2hJhWqIlIKfoCUowYnmolmgs5w3APOn-ogWHJQCrfkSPdxnj2PAe58OeIjPeOq7dsD7OJStz7grqR8f8VP_-ERC8n-KH92hwuPUD-3UxxEn3xVXyddZTHgoNdKPm5IOF-g0tEP2n17ec3T__fb3zU-y_vXj7ubbmjhB5USUtMpTa4MWDbOK21ZA6x1XVglhA5ONFkFq10qvXQBqHfOhC6wTDaeMc36Ovhx7dynWI_Nktn12fhja0ceSDWNUAjBKZ_TqP3QTSxrrdTPFV6AZQKXokXIp5px8MLvUb9t0MBTMLN8c5Zsq38zyjayZy5fmYre-e0u82q4AOwJ5N2v16d_q91v_AogukDk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2213908200</pqid></control><display><type>article</type><title>Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>González-Pacheco, Noelia ; Sánchez-Luna, Manuel ; Chimenti-Camacho, Paz ; Santos-González, Martín ; Palau-Concejo, Paula ; Tendillo-Cortijo, Francisco</creator><creatorcontrib>González-Pacheco, Noelia ; Sánchez-Luna, Manuel ; Chimenti-Camacho, Paz ; Santos-González, Martín ; Palau-Concejo, Paula ; Tendillo-Cortijo, Francisco</creatorcontrib><description>The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO
2
removal while potentially reducing the risk of ventilator-induced lung injury.
Objective
To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.
Study design
Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO
2
). After 12 h of mechanical ventilation, the pulmonary histologic pattern was analyzed.
Results
We found in the 10 Hz group with the higher VThf compared with the 20 Hz and very low VThf group more evident and more severe histological lesions with inflammatory infiltrate within the alveolar wall and alveolar space, as well as large areas of parenchyma consolidation and areas of alveolar hemorrhage in the more severe cases.
Conclusion
The use of very low VThf compared with higher VThf at similar CO
2
removal reduces lung injury in a neonatal animal model of lung injury after prolonged mechanical ventilation with HFOV combined with VG.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-019-0338-5</identifier><identifier>PMID: 30770883</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>14/63 ; 692/420/256/2516 ; 692/700/459/1748 ; Alveoli ; Animal models ; Animals ; Animals, Newborn ; Carbon dioxide ; Disease Models, Animal ; Health risks ; Hemorrhage ; High-Frequency Ventilation - adverse effects ; High-Frequency Ventilation - methods ; Humans ; Infant, Newborn ; Inflammation ; Injury prevention ; Lesions ; Lungs ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Neonates ; Parenchyma ; Pattern analysis ; Pediatric Surgery ; Pediatrics ; Respiratory distress syndrome ; Respiratory Distress Syndrome, Newborn - therapy ; Respiratory therapy ; Risk reduction ; Swine ; Tidal Volume ; Ventilation ; Ventilator-Induced Lung Injury - prevention & control ; Ventilators</subject><ispartof>Journal of perinatology, 2019-05, Vol.39 (5), p.730-736</ispartof><rights>Springer Nature America, Inc. 2019</rights><rights>2019© Springer Nature America, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-75b7e1bbf8462b73ba40aec37b744bf25684f58ca5e8cf01bc2efdf2d46312333</citedby><cites>FETCH-LOGICAL-c415t-75b7e1bbf8462b73ba40aec37b744bf25684f58ca5e8cf01bc2efdf2d46312333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-019-0338-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-019-0338-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30770883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Pacheco, Noelia</creatorcontrib><creatorcontrib>Sánchez-Luna, Manuel</creatorcontrib><creatorcontrib>Chimenti-Camacho, Paz</creatorcontrib><creatorcontrib>Santos-González, Martín</creatorcontrib><creatorcontrib>Palau-Concejo, Paula</creatorcontrib><creatorcontrib>Tendillo-Cortijo, Francisco</creatorcontrib><title>Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO
2
removal while potentially reducing the risk of ventilator-induced lung injury.
Objective
To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.
Study design
Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO
2
). After 12 h of mechanical ventilation, the pulmonary histologic pattern was analyzed.
Results
We found in the 10 Hz group with the higher VThf compared with the 20 Hz and very low VThf group more evident and more severe histological lesions with inflammatory infiltrate within the alveolar wall and alveolar space, as well as large areas of parenchyma consolidation and areas of alveolar hemorrhage in the more severe cases.
Conclusion
The use of very low VThf compared with higher VThf at similar CO
2
removal reduces lung injury in a neonatal animal model of lung injury after prolonged mechanical ventilation with HFOV combined with VG.</description><subject>14/63</subject><subject>692/420/256/2516</subject><subject>692/700/459/1748</subject><subject>Alveoli</subject><subject>Animal models</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Carbon dioxide</subject><subject>Disease Models, Animal</subject><subject>Health risks</subject><subject>Hemorrhage</subject><subject>High-Frequency Ventilation - adverse effects</subject><subject>High-Frequency Ventilation - methods</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Injury prevention</subject><subject>Lesions</subject><subject>Lungs</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Parenchyma</subject><subject>Pattern analysis</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Respiratory therapy</subject><subject>Risk reduction</subject><subject>Swine</subject><subject>Tidal Volume</subject><subject>Ventilation</subject><subject>Ventilator-Induced Lung Injury - prevention & control</subject><subject>Ventilators</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM1qGzEURkVJqJ2kD9BNEGTTjZqrv5G8LCFtA4Zumm3ESCMlY8YjVxo5-O2rwUkKhawEV-f77uUg9JnCVwpcX2dBuWIE6IoA55rID2hJhWqIlIKfoCUowYnmolmgs5w3APOn-ogWHJQCrfkSPdxnj2PAe58OeIjPeOq7dsD7OJStz7grqR8f8VP_-ERC8n-KH92hwuPUD-3UxxEn3xVXyddZTHgoNdKPm5IOF-g0tEP2n17ec3T__fb3zU-y_vXj7ubbmjhB5USUtMpTa4MWDbOK21ZA6x1XVglhA5ONFkFq10qvXQBqHfOhC6wTDaeMc36Ovhx7dynWI_Nktn12fhja0ceSDWNUAjBKZ_TqP3QTSxrrdTPFV6AZQKXokXIp5px8MLvUb9t0MBTMLN8c5Zsq38zyjayZy5fmYre-e0u82q4AOwJ5N2v16d_q91v_AogukDk</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>González-Pacheco, Noelia</creator><creator>Sánchez-Luna, Manuel</creator><creator>Chimenti-Camacho, Paz</creator><creator>Santos-González, Martín</creator><creator>Palau-Concejo, Paula</creator><creator>Tendillo-Cortijo, Francisco</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury</title><author>González-Pacheco, Noelia ; Sánchez-Luna, Manuel ; Chimenti-Camacho, Paz ; Santos-González, Martín ; Palau-Concejo, Paula ; Tendillo-Cortijo, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-75b7e1bbf8462b73ba40aec37b744bf25684f58ca5e8cf01bc2efdf2d46312333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>14/63</topic><topic>692/420/256/2516</topic><topic>692/700/459/1748</topic><topic>Alveoli</topic><topic>Animal models</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Carbon dioxide</topic><topic>Disease Models, Animal</topic><topic>Health risks</topic><topic>Hemorrhage</topic><topic>High-Frequency Ventilation - adverse effects</topic><topic>High-Frequency Ventilation - methods</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Inflammation</topic><topic>Injury prevention</topic><topic>Lesions</topic><topic>Lungs</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Parenchyma</topic><topic>Pattern analysis</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Respiratory therapy</topic><topic>Risk reduction</topic><topic>Swine</topic><topic>Tidal Volume</topic><topic>Ventilation</topic><topic>Ventilator-Induced Lung Injury - prevention & control</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Pacheco, Noelia</creatorcontrib><creatorcontrib>Sánchez-Luna, Manuel</creatorcontrib><creatorcontrib>Chimenti-Camacho, Paz</creatorcontrib><creatorcontrib>Santos-González, Martín</creatorcontrib><creatorcontrib>Palau-Concejo, Paula</creatorcontrib><creatorcontrib>Tendillo-Cortijo, Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Pacheco, Noelia</au><au>Sánchez-Luna, Manuel</au><au>Chimenti-Camacho, Paz</au><au>Santos-González, Martín</au><au>Palau-Concejo, Paula</au><au>Tendillo-Cortijo, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>39</volume><issue>5</issue><spage>730</spage><epage>736</epage><pages>730-736</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO
2
removal while potentially reducing the risk of ventilator-induced lung injury.
Objective
To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.
Study design
Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO
2
). After 12 h of mechanical ventilation, the pulmonary histologic pattern was analyzed.
Results
We found in the 10 Hz group with the higher VThf compared with the 20 Hz and very low VThf group more evident and more severe histological lesions with inflammatory infiltrate within the alveolar wall and alveolar space, as well as large areas of parenchyma consolidation and areas of alveolar hemorrhage in the more severe cases.
Conclusion
The use of very low VThf compared with higher VThf at similar CO
2
removal reduces lung injury in a neonatal animal model of lung injury after prolonged mechanical ventilation with HFOV combined with VG.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>30770883</pmid><doi>10.1038/s41372-019-0338-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of perinatology, 2019-05, Vol.39 (5), p.730-736 |
| issn | 0743-8346 1476-5543 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 14/63 692/420/256/2516 692/700/459/1748 Alveoli Animal models Animals Animals, Newborn Carbon dioxide Disease Models, Animal Health risks Hemorrhage High-Frequency Ventilation - adverse effects High-Frequency Ventilation - methods Humans Infant, Newborn Inflammation Injury prevention Lesions Lungs Mechanical ventilation Medicine Medicine & Public Health Neonates Parenchyma Pattern analysis Pediatric Surgery Pediatrics Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - therapy Respiratory therapy Risk reduction Swine Tidal Volume Ventilation Ventilator-Induced Lung Injury - prevention & control Ventilators |
| title | Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury |
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