Automatic Full Glycan Structural Determination through Logically Derived Sequence Tandem Mass Spectrometry

Glycans have diverse functions and play vital roles in many biological systems, such as influenza, vaccines, and cancer biomarkers. However, full structural identification of glycans remains challenging. The glycan structure was conventionally determined by chemical methods or NMR spectroscopy, whic...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2019-09, Vol.20 (18), p.2351-2359
Hauptverfasser:	Tsai, Shang‐Ting, Liew, Chia Yen, Hsu, Chen, Huang, Shih‐Pei, Weng, Wei‐Chien, Kuo, Yu‐Hsiang, Ni, Chi‐Kung
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological properties Biological samples Biomarkers Cancer vaccines Cow's milk Glycan glycoconjugates High-performance liquid chromatography HPLC Influenza Ions Isomers Liquid chromatography Magnetic resonance spectroscopy Mass spectrometry Mass spectroscopy Milk Monosaccharides NMR NMR spectroscopy Nuclear magnetic resonance Nucleotide sequence Oligosaccharides Organic chemistry Polysaccharides Scientific imaging Sensitivity structure elucidation Vaccines
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