Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study
Summary The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Ch...
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| Veröffentlicht in: | Current medical science 2019-04, Vol.39 (2), p.204-210 |
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| creator | Hu, Ying Shi, Li-xin Zhang, Qiao Peng, Nian-chun |
| description | Summary
The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Chinese Diabetic Individuals, REACTION) of risk factors of type 2 diabetes in China were followed up for 3 years, with MS being diagnosed by adult treatment panel III (ATPIII) combined with waist circumference in Asian population and renal function being evaluated by eGFR |
| doi_str_mv | 10.1007/s11596-019-2020-8 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2213931916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2213931916</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-c4e9f5945c605222a1a92285ed6100e206ee24c53f156040fe59c2d1a500a34c3</originalsourceid><addsrcrecordid>eNp9kEFvFCEUx4nR2Kb2A3hpOHoZy3sM06G3ZtW2scbGauKNsMwbF7sLKzA28-1ls63HnoD8f-8f3o-xtyDegxBnpxlA6a4RoBsUKJr-BTtEhbLptf75st5FTetbHLDjnP1SSMBOQo-v2YEEAZ0COGTb6-AS2UwD_-bzPY8jX6xSDN7xz34INPMPPu_yzH3gt7Z4CiXzB19W_AsVu4zrit7NYUhxQ-f8gstmJpv4bYp5S674v8QXcRVT4XdlGuY37NVo15mOH88j9uPTx--Lq-bm6-X14uKmcbJtS-Na0qPSrXKdUIhowWrEXtHQ1e0JRUeErVNyBNWJVoyktMMBrBLCytbJI_Zu37tN8c9EuZiNz47WaxsoTtkggtQSNHQVhT3q6p9zotFsk9_YNBsQZufa7F2b6trsXJu-zpw81k_LDQ3_J57MVgD3QK5R-EXJ_I5TCnXlZ1r_AYJIiJI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2213931916</pqid></control><display><type>article</type><title>Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Alma/SFX Local Collection</source><creator>Hu, Ying ; Shi, Li-xin ; Zhang, Qiao ; Peng, Nian-chun</creator><creatorcontrib>Hu, Ying ; Shi, Li-xin ; Zhang, Qiao ; Peng, Nian-chun</creatorcontrib><description><![CDATA[Summary
The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Chinese Diabetic Individuals, REACTION) of risk factors of type 2 diabetes in China were followed up for 3 years, with MS being diagnosed by adult treatment panel III (ATPIII) combined with waist circumference in Asian population and renal function being evaluated by eGFR <60 mL·min
−1
(1.73 m
2)−1
and rapid decline of eGFR ≤30%. The results showed that as compared with the non-MS group, the adjusted odds ratios (ORs) of CKD and rapid decline of eGFR were 1.64 (OR: 1.64; 95% CI: 1.20–2.25,
P
<0.05) and 1.23 (OR: 1.23; 95% CI: 1.05–1.43,
P
<0.05) respectively in MS group. With the increase in the number (0, 1, 2, 3 and ≥4) of MS components, the prevalence of CKD was 1.42%, 1.44%, 2.80%, 3.42%, and 4.03% (
P
<0.001), respectively. The ORs of incident CKD were 1.67 (OR: 1.67; 95% CI: 1.22–2.27,
P
<0.05) for high TG, 1.50 (OR: 1.50; 95% CI: 1.10–2.05,
P
<0.05) for low HDL-C, and 1.39 (OR: 1.39; 95% CI: 1.02–1.91,
P
<0.05) for hyperglycemia. The risk for developing incident CKD was higher in the group with the highest HOMA-IR than in the group with the lowest HOMA-IR (OR: 1.83; 95% CI: 1.16–2.89,
P
<0.05). It is suggested that MS is an independent risk factor for incident CKD. The occurrence and development of CKD is closely related to insulin resistance.]]></description><identifier>ISSN: 2096-5230</identifier><identifier>EISSN: 2523-899X</identifier><identifier>DOI: 10.1007/s11596-019-2020-8</identifier><identifier>PMID: 31016511</identifier><language>eng</language><publisher>Wuhan: Huazhong University of Science and Technology</publisher><subject>Diabetes Mellitus, Type 2 - complications ; Female ; Glomerular Filtration Rate - physiology ; Humans ; Insulin Resistance - physiology ; Male ; Medicine ; Medicine & Public Health ; Metabolic Syndrome - complications ; Middle Aged ; Prospective Studies ; Renal Insufficiency, Chronic - etiology ; Risk Factors</subject><ispartof>Current medical science, 2019-04, Vol.39 (2), p.204-210</ispartof><rights>Huazhong University of Science and Technology 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-c4e9f5945c605222a1a92285ed6100e206ee24c53f156040fe59c2d1a500a34c3</citedby><cites>FETCH-LOGICAL-c344t-c4e9f5945c605222a1a92285ed6100e206ee24c53f156040fe59c2d1a500a34c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11596-019-2020-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11596-019-2020-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31016511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Ying</creatorcontrib><creatorcontrib>Shi, Li-xin</creatorcontrib><creatorcontrib>Zhang, Qiao</creatorcontrib><creatorcontrib>Peng, Nian-chun</creatorcontrib><title>Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study</title><title>Current medical science</title><addtitle>CURR MED SCI</addtitle><addtitle>Curr Med Sci</addtitle><description><![CDATA[Summary
The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Chinese Diabetic Individuals, REACTION) of risk factors of type 2 diabetes in China were followed up for 3 years, with MS being diagnosed by adult treatment panel III (ATPIII) combined with waist circumference in Asian population and renal function being evaluated by eGFR <60 mL·min
−1
(1.73 m
2)−1
and rapid decline of eGFR ≤30%. The results showed that as compared with the non-MS group, the adjusted odds ratios (ORs) of CKD and rapid decline of eGFR were 1.64 (OR: 1.64; 95% CI: 1.20–2.25,
P
<0.05) and 1.23 (OR: 1.23; 95% CI: 1.05–1.43,
P
<0.05) respectively in MS group. With the increase in the number (0, 1, 2, 3 and ≥4) of MS components, the prevalence of CKD was 1.42%, 1.44%, 2.80%, 3.42%, and 4.03% (
P
<0.001), respectively. The ORs of incident CKD were 1.67 (OR: 1.67; 95% CI: 1.22–2.27,
P
<0.05) for high TG, 1.50 (OR: 1.50; 95% CI: 1.10–2.05,
P
<0.05) for low HDL-C, and 1.39 (OR: 1.39; 95% CI: 1.02–1.91,
P
<0.05) for hyperglycemia. The risk for developing incident CKD was higher in the group with the highest HOMA-IR than in the group with the lowest HOMA-IR (OR: 1.83; 95% CI: 1.16–2.89,
P
<0.05). It is suggested that MS is an independent risk factor for incident CKD. The occurrence and development of CKD is closely related to insulin resistance.]]></description><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Syndrome - complications</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Risk Factors</subject><issn>2096-5230</issn><issn>2523-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFvFCEUx4nR2Kb2A3hpOHoZy3sM06G3ZtW2scbGauKNsMwbF7sLKzA28-1ls63HnoD8f-8f3o-xtyDegxBnpxlA6a4RoBsUKJr-BTtEhbLptf75st5FTetbHLDjnP1SSMBOQo-v2YEEAZ0COGTb6-AS2UwD_-bzPY8jX6xSDN7xz34INPMPPu_yzH3gt7Z4CiXzB19W_AsVu4zrit7NYUhxQ-f8gstmJpv4bYp5S674v8QXcRVT4XdlGuY37NVo15mOH88j9uPTx--Lq-bm6-X14uKmcbJtS-Na0qPSrXKdUIhowWrEXtHQ1e0JRUeErVNyBNWJVoyktMMBrBLCytbJI_Zu37tN8c9EuZiNz47WaxsoTtkggtQSNHQVhT3q6p9zotFsk9_YNBsQZufa7F2b6trsXJu-zpw81k_LDQ3_J57MVgD3QK5R-EXJ_I5TCnXlZ1r_AYJIiJI</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Hu, Ying</creator><creator>Shi, Li-xin</creator><creator>Zhang, Qiao</creator><creator>Peng, Nian-chun</creator><general>Huazhong University of Science and Technology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study</title><author>Hu, Ying ; Shi, Li-xin ; Zhang, Qiao ; Peng, Nian-chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-c4e9f5945c605222a1a92285ed6100e206ee24c53f156040fe59c2d1a500a34c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Syndrome - complications</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Ying</creatorcontrib><creatorcontrib>Shi, Li-xin</creatorcontrib><creatorcontrib>Zhang, Qiao</creatorcontrib><creatorcontrib>Peng, Nian-chun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Ying</au><au>Shi, Li-xin</au><au>Zhang, Qiao</au><au>Peng, Nian-chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study</atitle><jtitle>Current medical science</jtitle><stitle>CURR MED SCI</stitle><addtitle>Curr Med Sci</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>39</volume><issue>2</issue><spage>204</spage><epage>210</epage><pages>204-210</pages><issn>2096-5230</issn><eissn>2523-899X</eissn><abstract><![CDATA[Summary
The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Chinese Diabetic Individuals, REACTION) of risk factors of type 2 diabetes in China were followed up for 3 years, with MS being diagnosed by adult treatment panel III (ATPIII) combined with waist circumference in Asian population and renal function being evaluated by eGFR <60 mL·min
−1
(1.73 m
2)−1
and rapid decline of eGFR ≤30%. The results showed that as compared with the non-MS group, the adjusted odds ratios (ORs) of CKD and rapid decline of eGFR were 1.64 (OR: 1.64; 95% CI: 1.20–2.25,
P
<0.05) and 1.23 (OR: 1.23; 95% CI: 1.05–1.43,
P
<0.05) respectively in MS group. With the increase in the number (0, 1, 2, 3 and ≥4) of MS components, the prevalence of CKD was 1.42%, 1.44%, 2.80%, 3.42%, and 4.03% (
P
<0.001), respectively. The ORs of incident CKD were 1.67 (OR: 1.67; 95% CI: 1.22–2.27,
P
<0.05) for high TG, 1.50 (OR: 1.50; 95% CI: 1.10–2.05,
P
<0.05) for low HDL-C, and 1.39 (OR: 1.39; 95% CI: 1.02–1.91,
P
<0.05) for hyperglycemia. The risk for developing incident CKD was higher in the group with the highest HOMA-IR than in the group with the lowest HOMA-IR (OR: 1.83; 95% CI: 1.16–2.89,
P
<0.05). It is suggested that MS is an independent risk factor for incident CKD. The occurrence and development of CKD is closely related to insulin resistance.]]></abstract><cop>Wuhan</cop><pub>Huazhong University of Science and Technology</pub><pmid>31016511</pmid><doi>10.1007/s11596-019-2020-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Diabetes Mellitus, Type 2 - complications Female Glomerular Filtration Rate - physiology Humans Insulin Resistance - physiology Male Medicine Medicine & Public Health Metabolic Syndrome - complications Middle Aged Prospective Studies Renal Insufficiency, Chronic - etiology Risk Factors |
| title | Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study |
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