Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice

Sepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature ( T a ) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually i...

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Veröffentlicht in:	Basic research in cardiology 2019-05, Vol.114 (3), p.26-20, Article 26
Hauptverfasser:	Ndongson-Dongmo, Bernadin, Lang, Guang-Ping, Mece, Odeta, Hechaichi, Nadine, Lajqi, Trim, Hoyer, Dirk, Brodhun, Michael, Heller, Regine, Wetzker, Reinhard, Franz, Marcus, Levy, Finn Olav, Bauer, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Ambient temperature Animal tissues Animals Apoptosis Autonomic nervous system Autonomic Nervous System - physiopathology Body Temperature Regulation Cardiology Cardiomyocytes Combined treatment Contraction Cytokines - metabolism Disease Models, Animal Disease Progression E coli Heart - innervation Heart Diseases - chemically induced Heart Diseases - metabolism Heart Diseases - physiopathology Heart rate Hemodynamics Housing, Animal Inflammation Inflammation Mediators - metabolism Inflammatory response Leukocytes Lipopolysaccharides Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mortality Muscle contraction Myocardial Contraction Necrosis Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Nitrotyrosine Original Contribution Receptors, Adrenergic, beta-2 - metabolism Reduction Rodents Sepsis Signal Transduction Signaling Systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - chemically induced Systemic Inflammatory Response Syndrome - metabolism Systemic Inflammatory Response Syndrome - physiopathology Temperature Ventricle
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