Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diami...
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| Veröffentlicht in: | MedChemComm 2019-03, Vol.10 (3), p.484-487 |
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| creator | Ballantine, Ross D McCallion, Conor E Nassour, Elie Tokajian, Sima Cochrane, Stephen A |
| description | Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-
-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria. |
| doi_str_mv | 10.1039/c9md00031c |
| format | Article |
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| source | Royal Society Of Chemistry Journals 2008-; PubMed Central |
| subjects | Amino acids Antibiotics Antiinfectives and antibacterials Antimicrobial peptides Bacteria Chemistry Gram-negative bacteria Isoleucine Multidrug resistance Peptides Synthesis Tridecaptins |
| title | Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria |
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