Effect of Triclosan-Coated Suture on Surgical Site Infection of Abdominal Fascial Closures
Background: Surgical site infections (SSIs) are a serious problem after abdominal surgery. This study aimed to compare closure of fascia with triclosan-coated monofilament polydioxanone (PDS) or standard PDS in decreasing the incidence of SSIs in patients who underwent abdominal surgery. Methods: In...
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| Veröffentlicht in: | Surgical infections 2019-12, Vol.20 (8), p.658-664 |
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| creator | Olmez, Tolga Berkesoglu, Mustafa Turkmenoglu, Ozgur Colak, Tahsin |
| description | Background:
Surgical site infections (SSIs) are a serious problem after abdominal surgery. This study aimed to compare closure of fascia with triclosan-coated monofilament polydioxanone (PDS) or standard PDS in decreasing the incidence of SSIs in patients who underwent abdominal surgery.
Methods:
In this randomized study, a total of 890 consecutive patients undergoing laparotomy for any gastrointestinal pathology were allocated to closure of the fascia with triclosan-coated PDS (treatment group; TG) or standard PDS (control group; CG). Patients were assessed every day during the hospital stay for SSIs and at the first, second, and fourth week after discharge. The surgical site was assessed in terms of superficial, deep incisional, or organ/site SSI.
Results:
The main important finding was that SSIs were reduced as much as 24% by using triclosan-coated PDS. Surgical site infections occurred in 200 patients (22.4%), with 105 being early (in the first week) and 95 occurring late. Eighty five of the SSIs (19.1%) were noted in patients in the TG, whereas 115 of them (25.8%) were in the CG (p = 0.016). The infections were superficial in 126 patients, deep incisional in 48 patients, and organ/site in 26 patients. Most of patients (n = 651) had clean-contaminated sites. In subgroup analysis, SSI rates with triclosan-coated PDS were lower in clean, clean-contaminated, and contaminated incisions (0 in the TG versus 24.2% in the CG; p = 0.009; 13.6% in the TG versus 24.3% in the CG, p = 0.001; and 16.6% in the TG versus 27.8% in the CG; p |
| doi_str_mv | 10.1089/sur.2019.052 |
| format | Article |
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Surgical site infections (SSIs) are a serious problem after abdominal surgery. This study aimed to compare closure of fascia with triclosan-coated monofilament polydioxanone (PDS) or standard PDS in decreasing the incidence of SSIs in patients who underwent abdominal surgery.
Methods:
In this randomized study, a total of 890 consecutive patients undergoing laparotomy for any gastrointestinal pathology were allocated to closure of the fascia with triclosan-coated PDS (treatment group; TG) or standard PDS (control group; CG). Patients were assessed every day during the hospital stay for SSIs and at the first, second, and fourth week after discharge. The surgical site was assessed in terms of superficial, deep incisional, or organ/site SSI.
Results:
The main important finding was that SSIs were reduced as much as 24% by using triclosan-coated PDS. Surgical site infections occurred in 200 patients (22.4%), with 105 being early (in the first week) and 95 occurring late. Eighty five of the SSIs (19.1%) were noted in patients in the TG, whereas 115 of them (25.8%) were in the CG (p = 0.016). The infections were superficial in 126 patients, deep incisional in 48 patients, and organ/site in 26 patients. Most of patients (n = 651) had clean-contaminated sites. In subgroup analysis, SSI rates with triclosan-coated PDS were lower in clean, clean-contaminated, and contaminated incisions (0 in the TG versus 24.2% in the CG; p = 0.009; 13.6% in the TG versus 24.3% in the CG, p = 0.001; and 16.6% in the TG versus 27.8% in the CG; p < 0.0001, respectively).
Conclusions:
Closure of the fascia with triclosan-coated PDS decreased SSI rates as much as 24%. Also, SSIs were decreased significantly at clean, clean-contaminated, and contaminated sites. Therefore, triclosan-coated PDS might be recommended for fascial closure as a means of decreasing SSIs.</description><identifier>ISSN: 1096-2964</identifier><identifier>EISSN: 1557-8674</identifier><identifier>DOI: 10.1089/sur.2019.052</identifier><identifier>PMID: 31009327</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Abdominal Wound Closure Techniques - adverse effects ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Infective Agents, Local - administration & dosage ; Humans ; Incidence ; Middle Aged ; Original Articles ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - prevention & control ; Suture Techniques - adverse effects ; Triclosan - administration & dosage ; Young Adult</subject><ispartof>Surgical infections, 2019-12, Vol.20 (8), p.658-664</ispartof><rights>2019, Mary Ann Liebert, Inc., publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-715aea914af0486151f56346a691a4af081317a69a9393f842e1e2140bd65a273</citedby><cites>FETCH-LOGICAL-c334t-715aea914af0486151f56346a691a4af081317a69a9393f842e1e2140bd65a273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31009327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olmez, Tolga</creatorcontrib><creatorcontrib>Berkesoglu, Mustafa</creatorcontrib><creatorcontrib>Turkmenoglu, Ozgur</creatorcontrib><creatorcontrib>Colak, Tahsin</creatorcontrib><title>Effect of Triclosan-Coated Suture on Surgical Site Infection of Abdominal Fascial Closures</title><title>Surgical infections</title><addtitle>Surg Infect (Larchmt)</addtitle><description>Background:
Surgical site infections (SSIs) are a serious problem after abdominal surgery. This study aimed to compare closure of fascia with triclosan-coated monofilament polydioxanone (PDS) or standard PDS in decreasing the incidence of SSIs in patients who underwent abdominal surgery.
Methods:
In this randomized study, a total of 890 consecutive patients undergoing laparotomy for any gastrointestinal pathology were allocated to closure of the fascia with triclosan-coated PDS (treatment group; TG) or standard PDS (control group; CG). Patients were assessed every day during the hospital stay for SSIs and at the first, second, and fourth week after discharge. The surgical site was assessed in terms of superficial, deep incisional, or organ/site SSI.
Results:
The main important finding was that SSIs were reduced as much as 24% by using triclosan-coated PDS. Surgical site infections occurred in 200 patients (22.4%), with 105 being early (in the first week) and 95 occurring late. Eighty five of the SSIs (19.1%) were noted in patients in the TG, whereas 115 of them (25.8%) were in the CG (p = 0.016). The infections were superficial in 126 patients, deep incisional in 48 patients, and organ/site in 26 patients. Most of patients (n = 651) had clean-contaminated sites. In subgroup analysis, SSI rates with triclosan-coated PDS were lower in clean, clean-contaminated, and contaminated incisions (0 in the TG versus 24.2% in the CG; p = 0.009; 13.6% in the TG versus 24.3% in the CG, p = 0.001; and 16.6% in the TG versus 27.8% in the CG; p < 0.0001, respectively).
Conclusions:
Closure of the fascia with triclosan-coated PDS decreased SSI rates as much as 24%. Also, SSIs were decreased significantly at clean, clean-contaminated, and contaminated sites. Therefore, triclosan-coated PDS might be recommended for fascial closure as a means of decreasing SSIs.</description><subject>Abdominal Wound Closure Techniques - adverse effects</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Humans</subject><subject>Incidence</subject><subject>Middle Aged</subject><subject>Original Articles</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Suture Techniques - adverse effects</subject><subject>Triclosan - administration & dosage</subject><subject>Young Adult</subject><issn>1096-2964</issn><issn>1557-8674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1PwzAQxS0EolDYmFFGBlL8FSceq6iFSpUYWhYWy0lsZJTExU4G_nsuamFkuvPz7z2dHkJ3BC8ILuRTHMOCYiIXOKNn6IpkWZ4WIufnsGMpUioFn6HrGD8xJjkV4hLNGMFYMppfofeVtaYeEm-TfXB166Pu09LrwTTJbhzGYBLfwxY-XK3bZOcGk2z6yeJAB9eyanznevhb61g7mCWEgC_eoAur22huT3OO3tarffmSbl-fN-Vym9aM8SHNSaaNloRri3khSEZsJhgXWkiiJ7EgjOTw0pJJZgtODTGUcFw1ItM0Z3P0cMw9BP81mjiozsXatK3ujR-johQCeAFdAPp4ROvgYwzGqkNwnQ7fimA1tangcjW1qaBNwO9PyWPVmeYP_q0PAHoEJln3fetMZcLwf-oPxDh_4A</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Olmez, Tolga</creator><creator>Berkesoglu, Mustafa</creator><creator>Turkmenoglu, Ozgur</creator><creator>Colak, Tahsin</creator><general>Mary Ann Liebert, Inc., publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Effect of Triclosan-Coated Suture on Surgical Site Infection of Abdominal Fascial Closures</title><author>Olmez, Tolga ; Berkesoglu, Mustafa ; Turkmenoglu, Ozgur ; Colak, Tahsin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-715aea914af0486151f56346a691a4af081317a69a9393f842e1e2140bd65a273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal Wound Closure Techniques - adverse effects</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Humans</topic><topic>Incidence</topic><topic>Middle Aged</topic><topic>Original Articles</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Suture Techniques - adverse effects</topic><topic>Triclosan - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olmez, Tolga</creatorcontrib><creatorcontrib>Berkesoglu, Mustafa</creatorcontrib><creatorcontrib>Turkmenoglu, Ozgur</creatorcontrib><creatorcontrib>Colak, Tahsin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olmez, Tolga</au><au>Berkesoglu, Mustafa</au><au>Turkmenoglu, Ozgur</au><au>Colak, Tahsin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Triclosan-Coated Suture on Surgical Site Infection of Abdominal Fascial Closures</atitle><jtitle>Surgical infections</jtitle><addtitle>Surg Infect (Larchmt)</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>20</volume><issue>8</issue><spage>658</spage><epage>664</epage><pages>658-664</pages><issn>1096-2964</issn><eissn>1557-8674</eissn><abstract>Background:
Surgical site infections (SSIs) are a serious problem after abdominal surgery. This study aimed to compare closure of fascia with triclosan-coated monofilament polydioxanone (PDS) or standard PDS in decreasing the incidence of SSIs in patients who underwent abdominal surgery.
Methods:
In this randomized study, a total of 890 consecutive patients undergoing laparotomy for any gastrointestinal pathology were allocated to closure of the fascia with triclosan-coated PDS (treatment group; TG) or standard PDS (control group; CG). Patients were assessed every day during the hospital stay for SSIs and at the first, second, and fourth week after discharge. The surgical site was assessed in terms of superficial, deep incisional, or organ/site SSI.
Results:
The main important finding was that SSIs were reduced as much as 24% by using triclosan-coated PDS. Surgical site infections occurred in 200 patients (22.4%), with 105 being early (in the first week) and 95 occurring late. Eighty five of the SSIs (19.1%) were noted in patients in the TG, whereas 115 of them (25.8%) were in the CG (p = 0.016). The infections were superficial in 126 patients, deep incisional in 48 patients, and organ/site in 26 patients. Most of patients (n = 651) had clean-contaminated sites. In subgroup analysis, SSI rates with triclosan-coated PDS were lower in clean, clean-contaminated, and contaminated incisions (0 in the TG versus 24.2% in the CG; p = 0.009; 13.6% in the TG versus 24.3% in the CG, p = 0.001; and 16.6% in the TG versus 27.8% in the CG; p < 0.0001, respectively).
Conclusions:
Closure of the fascia with triclosan-coated PDS decreased SSI rates as much as 24%. Also, SSIs were decreased significantly at clean, clean-contaminated, and contaminated sites. Therefore, triclosan-coated PDS might be recommended for fascial closure as a means of decreasing SSIs.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>31009327</pmid><doi>10.1089/sur.2019.052</doi><tpages>7</tpages></addata></record> |
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| subjects | Abdominal Wound Closure Techniques - adverse effects Adolescent Adult Aged Aged, 80 and over Anti-Infective Agents, Local - administration & dosage Humans Incidence Middle Aged Original Articles Surgical Wound Infection - epidemiology Surgical Wound Infection - prevention & control Suture Techniques - adverse effects Triclosan - administration & dosage Young Adult |
| title | Effect of Triclosan-Coated Suture on Surgical Site Infection of Abdominal Fascial Closures |
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