Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors

Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal development and cognition. However, the detailed function of ALK in the central nervous system (CNS) is still unclear. To elucidate the role of ALK in...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-05, Vol.62 (10), p.4915-4935
Hauptverfasser:	Fushimi, Makoto, Fujimori, Ikuo, Wakabayashi, Takeshi, Hasui, Tomoaki, Kawakita, Youichi, Imamura, Keisuke, Kato, Tomoko, Murakami, Morio, Ishii, Tsuyoshi, Kikko, Yorifumi, Kasahara, Maki, Nakatani, Atsushi, Hiura, Yuto, Miyamoto, Maki, Saikatendu, Kumar, Zou, Hua, Lane, Scott Weston, Lawson, J David, Imoto, Hiroshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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