Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation
Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limite...
Gespeichert in:
| Veröffentlicht in: | Monoclonal antibodies in immunodiagnosis and immunotherapy 2019-04, Vol.38 (2), p.85-88 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 88 |
|---|---|
| container_issue | 2 |
| container_start_page | 85 |
| container_title | Monoclonal antibodies in immunodiagnosis and immunotherapy |
| container_volume | 38 |
| creator | Pencheva-Demireva, Magdalena El-Darawish, Yosif Kavaldzhieva, Katerina Mladenov, Nikola Lazarov, Vladislav Dimitrova-Dikanarova, Dimitrina Markova, Tzvetanka Nikolov, Rumen Okamura, Haruki |
| description | Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limited because of difficulties in the preparation of sufficient number of highly cytotoxic/activated NK cells
in vitro
. We used cytokine stimulation to provide a suitable environment (activating receptor–ligand interactions) for the expansion of NK cells. This method potently expanded NK cells, and the final product was composed of highly proliferating NK cells. The expanded NK cells showed significant upregulation of various activation receptors such as CD69 and NKG2D. The latter is a particularly important receptor for triggering NK cell responses toward tumor cells. |
| doi_str_mv | 10.1089/mab.2019.0009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2213147522</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2212110933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-809653cfe946badcbb8435ad805e51465ec5a63d8f420540feb2f376996ee6d13</originalsourceid><addsrcrecordid>eNqF0M1LwzAYBvAgihtzR69S8OKlMx9N2h5l-C0q6M4hbd9KZtrMpD3svze1U8SLp4Twy8P7PggdE7wgOMvPG1UsKCb5AmOc76EpJSKN84SJ_V_3CZp7vw4Cp4QSxg_RhJHgGWNTdLfaOHjrjeq0bSNbR4-q650y0b02Bly0BGN89Oys0TW4URXbaLnt7LtuIXrpdLP7fYQOamU8zHfnDK2uLl-XN_HD0_Xt8uIhLmmGuzjDueCsrCFPRKGqsiiyhHFVZZgDJ4ngUHIlWJXVCcU8wTUUtGapyHMBICrCZuhszN04-9GD72SjfRnmVC3Y3ksaliRJyikN9PQPXdvetWG6QVFCvlqYoXhUpbPeO6jlxulGua0kWA49y9CzHHqWQ8_Bn-xS-6KB6kd_txoAG8HwrNrWaCjAdf_EfgIncIh_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2212110933</pqid></control><display><type>article</type><title>Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation</title><source>Alma/SFX Local Collection</source><creator>Pencheva-Demireva, Magdalena ; El-Darawish, Yosif ; Kavaldzhieva, Katerina ; Mladenov, Nikola ; Lazarov, Vladislav ; Dimitrova-Dikanarova, Dimitrina ; Markova, Tzvetanka ; Nikolov, Rumen ; Okamura, Haruki</creator><creatorcontrib>Pencheva-Demireva, Magdalena ; El-Darawish, Yosif ; Kavaldzhieva, Katerina ; Mladenov, Nikola ; Lazarov, Vladislav ; Dimitrova-Dikanarova, Dimitrina ; Markova, Tzvetanka ; Nikolov, Rumen ; Okamura, Haruki</creatorcontrib><description>Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limited because of difficulties in the preparation of sufficient number of highly cytotoxic/activated NK cells
in vitro
. We used cytokine stimulation to provide a suitable environment (activating receptor–ligand interactions) for the expansion of NK cells. This method potently expanded NK cells, and the final product was composed of highly proliferating NK cells. The expanded NK cells showed significant upregulation of various activation receptors such as CD69 and NKG2D. The latter is a particularly important receptor for triggering NK cell responses toward tumor cells.</description><identifier>ISSN: 2167-9436</identifier><identifier>EISSN: 2167-9436</identifier><identifier>DOI: 10.1089/mab.2019.0009</identifier><identifier>PMID: 31009333</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Activation ; Apoptosis ; Cancer ; CD69 antigen ; Cell proliferation ; Cytokines ; Cytotoxicity ; Natural killer cells ; NKG2 antigen ; Receptors ; Stimulation ; Tumor cells ; Up-regulation</subject><ispartof>Monoclonal antibodies in immunodiagnosis and immunotherapy, 2019-04, Vol.38 (2), p.85-88</ispartof><rights>2019, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. Apr 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-809653cfe946badcbb8435ad805e51465ec5a63d8f420540feb2f376996ee6d13</citedby><cites>FETCH-LOGICAL-c280t-809653cfe946badcbb8435ad805e51465ec5a63d8f420540feb2f376996ee6d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31009333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pencheva-Demireva, Magdalena</creatorcontrib><creatorcontrib>El-Darawish, Yosif</creatorcontrib><creatorcontrib>Kavaldzhieva, Katerina</creatorcontrib><creatorcontrib>Mladenov, Nikola</creatorcontrib><creatorcontrib>Lazarov, Vladislav</creatorcontrib><creatorcontrib>Dimitrova-Dikanarova, Dimitrina</creatorcontrib><creatorcontrib>Markova, Tzvetanka</creatorcontrib><creatorcontrib>Nikolov, Rumen</creatorcontrib><creatorcontrib>Okamura, Haruki</creatorcontrib><title>Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation</title><title>Monoclonal antibodies in immunodiagnosis and immunotherapy</title><addtitle>Monoclon Antib Immunodiagn Immunother</addtitle><description>Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limited because of difficulties in the preparation of sufficient number of highly cytotoxic/activated NK cells
in vitro
. We used cytokine stimulation to provide a suitable environment (activating receptor–ligand interactions) for the expansion of NK cells. This method potently expanded NK cells, and the final product was composed of highly proliferating NK cells. The expanded NK cells showed significant upregulation of various activation receptors such as CD69 and NKG2D. The latter is a particularly important receptor for triggering NK cell responses toward tumor cells.</description><subject>Activation</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>CD69 antigen</subject><subject>Cell proliferation</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Natural killer cells</subject><subject>NKG2 antigen</subject><subject>Receptors</subject><subject>Stimulation</subject><subject>Tumor cells</subject><subject>Up-regulation</subject><issn>2167-9436</issn><issn>2167-9436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqF0M1LwzAYBvAgihtzR69S8OKlMx9N2h5l-C0q6M4hbd9KZtrMpD3svze1U8SLp4Twy8P7PggdE7wgOMvPG1UsKCb5AmOc76EpJSKN84SJ_V_3CZp7vw4Cp4QSxg_RhJHgGWNTdLfaOHjrjeq0bSNbR4-q650y0b02Bly0BGN89Oys0TW4URXbaLnt7LtuIXrpdLP7fYQOamU8zHfnDK2uLl-XN_HD0_Xt8uIhLmmGuzjDueCsrCFPRKGqsiiyhHFVZZgDJ4ngUHIlWJXVCcU8wTUUtGapyHMBICrCZuhszN04-9GD72SjfRnmVC3Y3ksaliRJyikN9PQPXdvetWG6QVFCvlqYoXhUpbPeO6jlxulGua0kWA49y9CzHHqWQ8_Bn-xS-6KB6kd_txoAG8HwrNrWaCjAdf_EfgIncIh_</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Pencheva-Demireva, Magdalena</creator><creator>El-Darawish, Yosif</creator><creator>Kavaldzhieva, Katerina</creator><creator>Mladenov, Nikola</creator><creator>Lazarov, Vladislav</creator><creator>Dimitrova-Dikanarova, Dimitrina</creator><creator>Markova, Tzvetanka</creator><creator>Nikolov, Rumen</creator><creator>Okamura, Haruki</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation</title><author>Pencheva-Demireva, Magdalena ; El-Darawish, Yosif ; Kavaldzhieva, Katerina ; Mladenov, Nikola ; Lazarov, Vladislav ; Dimitrova-Dikanarova, Dimitrina ; Markova, Tzvetanka ; Nikolov, Rumen ; Okamura, Haruki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-809653cfe946badcbb8435ad805e51465ec5a63d8f420540feb2f376996ee6d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Activation</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>CD69 antigen</topic><topic>Cell proliferation</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Natural killer cells</topic><topic>NKG2 antigen</topic><topic>Receptors</topic><topic>Stimulation</topic><topic>Tumor cells</topic><topic>Up-regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pencheva-Demireva, Magdalena</creatorcontrib><creatorcontrib>El-Darawish, Yosif</creatorcontrib><creatorcontrib>Kavaldzhieva, Katerina</creatorcontrib><creatorcontrib>Mladenov, Nikola</creatorcontrib><creatorcontrib>Lazarov, Vladislav</creatorcontrib><creatorcontrib>Dimitrova-Dikanarova, Dimitrina</creatorcontrib><creatorcontrib>Markova, Tzvetanka</creatorcontrib><creatorcontrib>Nikolov, Rumen</creatorcontrib><creatorcontrib>Okamura, Haruki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Monoclonal antibodies in immunodiagnosis and immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pencheva-Demireva, Magdalena</au><au>El-Darawish, Yosif</au><au>Kavaldzhieva, Katerina</au><au>Mladenov, Nikola</au><au>Lazarov, Vladislav</au><au>Dimitrova-Dikanarova, Dimitrina</au><au>Markova, Tzvetanka</au><au>Nikolov, Rumen</au><au>Okamura, Haruki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation</atitle><jtitle>Monoclonal antibodies in immunodiagnosis and immunotherapy</jtitle><addtitle>Monoclon Antib Immunodiagn Immunother</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>38</volume><issue>2</issue><spage>85</spage><epage>88</epage><pages>85-88</pages><issn>2167-9436</issn><eissn>2167-9436</eissn><abstract>Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limited because of difficulties in the preparation of sufficient number of highly cytotoxic/activated NK cells
in vitro
. We used cytokine stimulation to provide a suitable environment (activating receptor–ligand interactions) for the expansion of NK cells. This method potently expanded NK cells, and the final product was composed of highly proliferating NK cells. The expanded NK cells showed significant upregulation of various activation receptors such as CD69 and NKG2D. The latter is a particularly important receptor for triggering NK cell responses toward tumor cells.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>31009333</pmid><doi>10.1089/mab.2019.0009</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2167-9436 |
| ispartof | Monoclonal antibodies in immunodiagnosis and immunotherapy, 2019-04, Vol.38 (2), p.85-88 |
| issn | 2167-9436 2167-9436 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2213147522 |
| source | Alma/SFX Local Collection |
| subjects | Activation Apoptosis Cancer CD69 antigen Cell proliferation Cytokines Cytotoxicity Natural killer cells NKG2 antigen Receptors Stimulation Tumor cells Up-regulation |
| title | Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A40%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Upregulation%20of%20Natural%20Killer%20Cells%20Proliferation%20by%20Cytokine%20Stimulation&rft.jtitle=Monoclonal%20antibodies%20in%20immunodiagnosis%20and%20immunotherapy&rft.au=Pencheva-Demireva,%20Magdalena&rft.date=2019-04-01&rft.volume=38&rft.issue=2&rft.spage=85&rft.epage=88&rft.pages=85-88&rft.issn=2167-9436&rft.eissn=2167-9436&rft_id=info:doi/10.1089/mab.2019.0009&rft_dat=%3Cproquest_cross%3E2212110933%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2212110933&rft_id=info:pmid/31009333&rfr_iscdi=true |