Role of cyclin‐dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway

Liver cancer is the fourth leading cause of cancer related mortality in the world, with hepatocellular carcinoma (HCC) representing the most common primary subtype. Two‐thirds of HCC patients have advanced disease when diagnosed, and for these patients, treatment strategies remain limited. In additi...

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Veröffentlicht in:	Hepatology research 2019-10, Vol.49 (10), p.1097-1108
Hauptverfasser:	Shen, Shen, Dean, Dylan C., Yu, Zujiang, Duan, Zhenfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis CDK inhibitor cell cycle Cell proliferation Chemotherapy Clinical trials Cyclin-dependent kinase cyclin‐dependent kinase (CDK) Drug resistance Hepatocellular carcinoma hepatocellular carcinoma (HCC) Kinases Liver cancer Patients Signal transduction
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