Furanodienone overcomes temozolomide resistance in glioblastoma through the downregulation of CSPG4‐Akt‐ERK signalling by inhibiting EGR1‐dependent transcription

Glioblastoma multiforme (GBM) is a highly aggressive type of brain tumour. Patients with GBM respond poorly to chemotherapy and have poor survival outcomes. Neuron‐glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), has been shown to contribute to critical processes, su...

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Veröffentlicht in:	Phytotherapy research 2019-06, Vol.33 (6), p.1736-1747
Hauptverfasser:	Chen, Lei, Liu, Yue‐cheng, Zheng, Yue‐yang, Xu, Ji, Zhang, Yuan, Liu, Wen‐lan, Li, Zong‐yang, Huang, Guo‐dong, Li, Wei‐ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AKT protein Antigens Apoptosis Apoptosis - drug effects Apoptosis - genetics Aquatic plants Attenuation Brain Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Caspase Cell Line, Tumor Cell survival Cell Survival - drug effects Cell Survival - genetics Chemoresistance Chemotherapy Chondroitin Sulfate Proteoglycans - genetics Chondroitin Sulfate Proteoglycans - metabolism CSPG4 Cytokines Cytotoxicity Down-Regulation - drug effects Down-Regulation - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Early Growth Response Protein 1 - physiology EGR-1 protein EGR1 Extracellular signal-regulated kinase Feedback loops furanodienone Furans - administration & dosage Furans - pharmacology Gene Expression Regulation, Neoplastic - drug effects Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - pathology Glioma Glioma cells Humans Immunofluorescence Inflammation Inhibition MAP Kinase Signaling System - drug effects Membrane Proteins - genetics Membrane Proteins - metabolism Mitochondria Negative feedback negative feedback loop Neuronal-glial interactions Proteoglycans Proto-Oncogene Proteins c-akt - metabolism Rhizomes Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacology Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Survival Temozolomide Temozolomide - administration & dosage Temozolomide - therapeutic use Transcription Transcription, Genetic - drug effects
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