Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model
We developed a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing a maxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site e...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2019-07, Vol.45 (7), p.1721-1732 |
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| creator | Hidaka, Kouki Mikuni-Takagaki, Yuko Wada-Takahashi, Satoko Saita, Makiko Kawamata, Ryota Sato, Takenori Kawata, Akira Miyamoto, Chihiro Maehata, Yojiro Watabe, Hirotaka Tani-Ishii, Nobuyuki Hamada, Nobushiro Takahashi, Shun-suke Deguchi, Shinji Takeuchi, Ryohei |
| description | We developed a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing a maxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-κB and TNF-α messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2019.02.015 |
| format | Article |
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To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-κB and TNF-α messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2019.02.015</identifier><identifier>PMID: 31006496</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Alendronate ; Animals ; Bisphosphonate-Associated Osteonecrosis of the Jaw - physiopathology ; Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control ; Bisphosphonate-related osteonecrosis of the jaw (BRONJ) ; Bone marrow ; Disease Models, Animal ; Female ; Low-intensity pulsed ultrasound (LIPUS) ; Osteogenesis - physiology ; Periodontitis ; Periodontitis - therapy ; Rats ; Rats, Wistar ; Systemic effect ; Tooth Socket - physiopathology ; Ultrasonic Therapy - methods ; Ultrasonic Waves</subject><ispartof>Ultrasound in medicine & biology, 2019-07, Vol.45 (7), p.1721-1732</ispartof><rights>2019 World Federation for Ultrasound in Medicine & Biology</rights><rights>Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-6f9a1ad6e2f54b981a8c38d97cffc2d98c6c74ff32829fa38091df08be7b59193</citedby><cites>FETCH-LOGICAL-c406t-6f9a1ad6e2f54b981a8c38d97cffc2d98c6c74ff32829fa38091df08be7b59193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2019.02.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31006496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hidaka, Kouki</creatorcontrib><creatorcontrib>Mikuni-Takagaki, Yuko</creatorcontrib><creatorcontrib>Wada-Takahashi, Satoko</creatorcontrib><creatorcontrib>Saita, Makiko</creatorcontrib><creatorcontrib>Kawamata, Ryota</creatorcontrib><creatorcontrib>Sato, Takenori</creatorcontrib><creatorcontrib>Kawata, Akira</creatorcontrib><creatorcontrib>Miyamoto, Chihiro</creatorcontrib><creatorcontrib>Maehata, Yojiro</creatorcontrib><creatorcontrib>Watabe, Hirotaka</creatorcontrib><creatorcontrib>Tani-Ishii, Nobuyuki</creatorcontrib><creatorcontrib>Hamada, Nobushiro</creatorcontrib><creatorcontrib>Takahashi, Shun-suke</creatorcontrib><creatorcontrib>Deguchi, Shinji</creatorcontrib><creatorcontrib>Takeuchi, Ryohei</creatorcontrib><title>Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>We developed a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing a maxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-κB and TNF-α messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients.</description><subject>Alendronate</subject><subject>Animals</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - physiopathology</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control</subject><subject>Bisphosphonate-related osteonecrosis of the jaw (BRONJ)</subject><subject>Bone marrow</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Low-intensity pulsed ultrasound (LIPUS)</subject><subject>Osteogenesis - physiology</subject><subject>Periodontitis</subject><subject>Periodontitis - therapy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Systemic effect</subject><subject>Tooth Socket - physiopathology</subject><subject>Ultrasonic Therapy - methods</subject><subject>Ultrasonic Waves</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvhFZDFiUuC7ew6MTdooS1a1FVFJW6WY49ZL1k72E6rfQZeGoctiCOH0a-Rv5lf4x-hV5TUlFD-ZldPQ44q7cH0LtSMUFETVhO6eoQWtGtFxQT9-hgtSENoteJMnKBnKe0IIS1v2qfopKGE8KXgC_RzHe6rK5_BJ5cPeDMNCQy-_b0_TN7gTYQ78Dnh86JDGPelwcHi9y6N2zCXVxmqGxiKGHydMgQPOobk0szlLeBP6r5au--ANypvw7g9JBeG8O2AnccK36iMPwcDw3P0xKri_-JBT9Htxw9fzi6r9fXF1dm7daWXhOeKW6GoMhyYXS170VHV6aYzotXWamZEp7lul9Y2rGPCqqYjghpLuh7afiWoaE7R6-PeMYYfE6Qs9y5pGAblIUxJMkZZSzmnpKBvj-h8UIpg5RjdXsWDpETOYcid_DcMOYchCZMljDL88sFn6svz39E_v1-A8yMA5do7B1Em7cBrMC6CztIE9z8-vwC_eqXO</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Hidaka, Kouki</creator><creator>Mikuni-Takagaki, Yuko</creator><creator>Wada-Takahashi, Satoko</creator><creator>Saita, Makiko</creator><creator>Kawamata, Ryota</creator><creator>Sato, Takenori</creator><creator>Kawata, Akira</creator><creator>Miyamoto, Chihiro</creator><creator>Maehata, Yojiro</creator><creator>Watabe, Hirotaka</creator><creator>Tani-Ishii, Nobuyuki</creator><creator>Hamada, Nobushiro</creator><creator>Takahashi, Shun-suke</creator><creator>Deguchi, Shinji</creator><creator>Takeuchi, Ryohei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model</title><author>Hidaka, Kouki ; Mikuni-Takagaki, Yuko ; Wada-Takahashi, Satoko ; Saita, Makiko ; Kawamata, Ryota ; Sato, Takenori ; Kawata, Akira ; Miyamoto, Chihiro ; Maehata, Yojiro ; Watabe, Hirotaka ; Tani-Ishii, Nobuyuki ; Hamada, Nobushiro ; Takahashi, Shun-suke ; Deguchi, Shinji ; Takeuchi, Ryohei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-6f9a1ad6e2f54b981a8c38d97cffc2d98c6c74ff32829fa38091df08be7b59193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alendronate</topic><topic>Animals</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - physiopathology</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control</topic><topic>Bisphosphonate-related osteonecrosis of the jaw (BRONJ)</topic><topic>Bone marrow</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Low-intensity pulsed ultrasound (LIPUS)</topic><topic>Osteogenesis - physiology</topic><topic>Periodontitis</topic><topic>Periodontitis - therapy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Systemic effect</topic><topic>Tooth Socket - physiopathology</topic><topic>Ultrasonic Therapy - methods</topic><topic>Ultrasonic Waves</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hidaka, Kouki</creatorcontrib><creatorcontrib>Mikuni-Takagaki, Yuko</creatorcontrib><creatorcontrib>Wada-Takahashi, Satoko</creatorcontrib><creatorcontrib>Saita, Makiko</creatorcontrib><creatorcontrib>Kawamata, Ryota</creatorcontrib><creatorcontrib>Sato, Takenori</creatorcontrib><creatorcontrib>Kawata, Akira</creatorcontrib><creatorcontrib>Miyamoto, Chihiro</creatorcontrib><creatorcontrib>Maehata, Yojiro</creatorcontrib><creatorcontrib>Watabe, Hirotaka</creatorcontrib><creatorcontrib>Tani-Ishii, Nobuyuki</creatorcontrib><creatorcontrib>Hamada, Nobushiro</creatorcontrib><creatorcontrib>Takahashi, Shun-suke</creatorcontrib><creatorcontrib>Deguchi, Shinji</creatorcontrib><creatorcontrib>Takeuchi, Ryohei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hidaka, Kouki</au><au>Mikuni-Takagaki, Yuko</au><au>Wada-Takahashi, Satoko</au><au>Saita, Makiko</au><au>Kawamata, Ryota</au><au>Sato, Takenori</au><au>Kawata, Akira</au><au>Miyamoto, Chihiro</au><au>Maehata, Yojiro</au><au>Watabe, Hirotaka</au><au>Tani-Ishii, Nobuyuki</au><au>Hamada, Nobushiro</au><au>Takahashi, Shun-suke</au><au>Deguchi, Shinji</au><au>Takeuchi, Ryohei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>45</volume><issue>7</issue><spage>1721</spage><epage>1732</epage><pages>1721-1732</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>We developed a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing a maxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-κB and TNF-α messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>31006496</pmid><doi>10.1016/j.ultrasmedbio.2019.02.015</doi><tpages>12</tpages></addata></record> |
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| subjects | Alendronate Animals Bisphosphonate-Associated Osteonecrosis of the Jaw - physiopathology Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control Bisphosphonate-related osteonecrosis of the jaw (BRONJ) Bone marrow Disease Models, Animal Female Low-intensity pulsed ultrasound (LIPUS) Osteogenesis - physiology Periodontitis Periodontitis - therapy Rats Rats, Wistar Systemic effect Tooth Socket - physiopathology Ultrasonic Therapy - methods Ultrasonic Waves |
| title | Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model |
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