Residual cardiovascular risk among people with diabetes

Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction st...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2019-04, Vol.21 (S1), p.28-38
Hauptverfasser: Dash, Satya, Leiter, Lawrence A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 38
container_issue S1
container_start_page 28
container_title Diabetes, obesity & metabolism
container_volume 21
creator Dash, Satya
Leiter, Lawrence A.
description Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction strategies have substantially reduced the risk of atherosclerotic CVD, yet patients with T2D continue to remain at increased risk for atherosclerotic CVD. Here, we will briefly review various proposed underlying mechanisms for this residual risk with a more in‐depth focus on the potential role of triglyceride‐rich lipoproteins in residual risk and potential avenues to target this pharmacologically.
doi_str_mv 10.1111/dom.13646
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2211952995</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2211952995</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-cf961cd85dee02385e8821038ba8444a9e87ad882d068694ecbc781992f4db83</originalsourceid><addsrcrecordid>eNp10F1LwzAUBuAgipvTC_-AFLzRi275appcyvyEyUB2X9LkVDvbtSarY__euE4vBHNzwuHh5fAidE7wmIQ3sU09JkxwcYCGhAsWE0bF4e5PY6kwHaAT75cYY85keowGjGBMeSKHKH0BX9pOV5HRzpbNp_amq7SLXOnfI103q9eohaatINqU67fIljqHNfhTdFToysPZfo7Q4v5uMX2MZ_OHp-nNLDYsYSI2hRLEWJlYAEyZTEBKSjCTuZacc61AptqGncVCCsXB5CaVRClacJtLNkJXfWzrmo8O_DqrS2-gqvQKms5nlBKiEqpUEujlH7psOrcKx-0UIzSwoK57ZVzjvYMia11Za7fNCM6-y8xCmdmuzGAv9oldXoP9lT_tBTDpwaasYPt_UnY7f-4jvwA0VHwT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2211312299</pqid></control><display><type>article</type><title>Residual cardiovascular risk among people with diabetes</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Dash, Satya ; Leiter, Lawrence A.</creator><creatorcontrib>Dash, Satya ; Leiter, Lawrence A.</creatorcontrib><description>Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction strategies have substantially reduced the risk of atherosclerotic CVD, yet patients with T2D continue to remain at increased risk for atherosclerotic CVD. Here, we will briefly review various proposed underlying mechanisms for this residual risk with a more in‐depth focus on the potential role of triglyceride‐rich lipoproteins in residual risk and potential avenues to target this pharmacologically.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.13646</identifier><identifier>PMID: 31002458</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Arteriosclerosis ; cardiovascular disease ; Cardiovascular diseases ; clinical trial ; Developing countries ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; dyslipidaemia ; LDCs ; lipid‐lowering therapy ; Lipoproteins ; Low density lipoprotein ; Metabolic disorders</subject><ispartof>Diabetes, obesity &amp; metabolism, 2019-04, Vol.21 (S1), p.28-38</ispartof><rights>2019 John Wiley &amp; Sons Ltd</rights><rights>2019 John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-cf961cd85dee02385e8821038ba8444a9e87ad882d068694ecbc781992f4db83</citedby><cites>FETCH-LOGICAL-c3536-cf961cd85dee02385e8821038ba8444a9e87ad882d068694ecbc781992f4db83</cites><orcidid>0000-0002-5167-2099 ; 0000-0002-1040-6229</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.13646$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.13646$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31002458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dash, Satya</creatorcontrib><creatorcontrib>Leiter, Lawrence A.</creatorcontrib><title>Residual cardiovascular risk among people with diabetes</title><title>Diabetes, obesity &amp; metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction strategies have substantially reduced the risk of atherosclerotic CVD, yet patients with T2D continue to remain at increased risk for atherosclerotic CVD. Here, we will briefly review various proposed underlying mechanisms for this residual risk with a more in‐depth focus on the potential role of triglyceride‐rich lipoproteins in residual risk and potential avenues to target this pharmacologically.</description><subject>Arteriosclerosis</subject><subject>cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>clinical trial</subject><subject>Developing countries</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>dyslipidaemia</subject><subject>LDCs</subject><subject>lipid‐lowering therapy</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Metabolic disorders</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10F1LwzAUBuAgipvTC_-AFLzRi275appcyvyEyUB2X9LkVDvbtSarY__euE4vBHNzwuHh5fAidE7wmIQ3sU09JkxwcYCGhAsWE0bF4e5PY6kwHaAT75cYY85keowGjGBMeSKHKH0BX9pOV5HRzpbNp_amq7SLXOnfI103q9eohaatINqU67fIljqHNfhTdFToysPZfo7Q4v5uMX2MZ_OHp-nNLDYsYSI2hRLEWJlYAEyZTEBKSjCTuZacc61AptqGncVCCsXB5CaVRClacJtLNkJXfWzrmo8O_DqrS2-gqvQKms5nlBKiEqpUEujlH7psOrcKx-0UIzSwoK57ZVzjvYMia11Za7fNCM6-y8xCmdmuzGAv9oldXoP9lT_tBTDpwaasYPt_UnY7f-4jvwA0VHwT</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Dash, Satya</creator><creator>Leiter, Lawrence A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5167-2099</orcidid><orcidid>https://orcid.org/0000-0002-1040-6229</orcidid></search><sort><creationdate>201904</creationdate><title>Residual cardiovascular risk among people with diabetes</title><author>Dash, Satya ; Leiter, Lawrence A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-cf961cd85dee02385e8821038ba8444a9e87ad882d068694ecbc781992f4db83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arteriosclerosis</topic><topic>cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>clinical trial</topic><topic>Developing countries</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>dyslipidaemia</topic><topic>LDCs</topic><topic>lipid‐lowering therapy</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Metabolic disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dash, Satya</creatorcontrib><creatorcontrib>Leiter, Lawrence A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity &amp; metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dash, Satya</au><au>Leiter, Lawrence A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residual cardiovascular risk among people with diabetes</atitle><jtitle>Diabetes, obesity &amp; metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2019-04</date><risdate>2019</risdate><volume>21</volume><issue>S1</issue><spage>28</spage><epage>38</epage><pages>28-38</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction strategies have substantially reduced the risk of atherosclerotic CVD, yet patients with T2D continue to remain at increased risk for atherosclerotic CVD. Here, we will briefly review various proposed underlying mechanisms for this residual risk with a more in‐depth focus on the potential role of triglyceride‐rich lipoproteins in residual risk and potential avenues to target this pharmacologically.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>31002458</pmid><doi>10.1111/dom.13646</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5167-2099</orcidid><orcidid>https://orcid.org/0000-0002-1040-6229</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1462-8902
ispartof Diabetes, obesity & metabolism, 2019-04, Vol.21 (S1), p.28-38
issn 1462-8902
1463-1326
language eng
recordid cdi_proquest_miscellaneous_2211952995
source Wiley Online Library Journals Frontfile Complete
subjects Arteriosclerosis
cardiovascular disease
Cardiovascular diseases
clinical trial
Developing countries
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
dyslipidaemia
LDCs
lipid‐lowering therapy
Lipoproteins
Low density lipoprotein
Metabolic disorders
title Residual cardiovascular risk among people with diabetes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T08%3A22%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Residual%20cardiovascular%20risk%20among%20people%20with%20diabetes&rft.jtitle=Diabetes,%20obesity%20&%20metabolism&rft.au=Dash,%20Satya&rft.date=2019-04&rft.volume=21&rft.issue=S1&rft.spage=28&rft.epage=38&rft.pages=28-38&rft.issn=1462-8902&rft.eissn=1463-1326&rft_id=info:doi/10.1111/dom.13646&rft_dat=%3Cproquest_cross%3E2211952995%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2211312299&rft_id=info:pmid/31002458&rfr_iscdi=true