Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives

Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives

By using diaryliodonium salts, a novel approach of a palladium-catalyzed cascade of diarylation/intramolecular dehydrogenative coupling reaction has been developed in the synthesis of phenanthro-imidazopyridine fused heteropolycycles. The method can tolerate various substrates, and the target produc...

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Veröffentlicht in:Organic letters 2019-06, Vol.21 (12), p.4402-4406
Hauptverfasser: Xue, Chenwei, Han, Jianwei, Zhao, Min, Wang, Limin
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creator Xue, Chenwei
Han, Jianwei
Zhao, Min
Wang, Limin
description By using diaryliodonium salts, a novel approach of a palladium-catalyzed cascade of diarylation/intramolecular dehydrogenative coupling reaction has been developed in the synthesis of phenanthro-imidazopyridine fused heteropolycycles. The method can tolerate various substrates, and the target products were rapidly constructed in one pot. Furthermore, studies of the detailed reaction mechanism provide an insight into the C–H functionalization of 2-aryl-imidazopyridine derivatives and the C–C bond formations in the presence of palladium catalyst.
doi_str_mv 10.1021/acs.orglett.9b00761
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title Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives
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