Dysregulation of humoral immunity in Foxp3 conditional-knockout mice

Foxp3+ regulatory T cells (Tregs) are crucial for maintaining tolerance to self-antigens and preventing autoimmune diseases. Loss of Foxp3 expression leads to autoimmunity and disrupts humoral immune responses, including hyperproduction of immunoglobulin E (IgE). Elucidation of how Tregs control ant...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-06, Vol.513 (4), p.787-793
Hauptverfasser:	Tai, Yuki, Sakamoto, Kazuki, Takano, Azumi, Haga, Katsura, Harada, Yohsuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Germinal center Humoral immunity Regulatory T cells T follicular helper
Online-Zugang:	Volltext
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