Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis
The aim of this study was to define the population-based familial clustering of atrial fibrillation (AF) that is associated with fibrosis and describe evidence for a heritable predisposition. Although a heritable contribution to AF is well-established and the association of fibrosis with AF is well-...
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| Veröffentlicht in: | JACC. Clinical electrophysiology 2019-04, Vol.5 (4), p.493-500 |
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| container_title | JACC. Clinical electrophysiology |
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| creator | Wilson, Brent D. Wasmund, Stephen L. Sachse, Frank B. Kaur, Gagandeep Marrouche, Nassir F. Cannon-Albright, Lisa A. |
| description | The aim of this study was to define the population-based familial clustering of atrial fibrillation (AF) that is associated with fibrosis and describe evidence for a heritable predisposition.
Although a heritable contribution to AF is well-established and the association of fibrosis with AF is well-recognized, no studies have analyzed the genetic contribution to AF co-occurring with fibrosis.
AF patients with magnetic resonance imaging–confirmed fibrosis were identified in a population-based health sciences center database linked to a Utah genealogy. Familial clustering of AF/fibrosis was defined by analysis of pairwise case relatedness, estimation of relative risk of AF/fibrosis in relatives, and identification of high-risk AF/fibrosis pedigrees.
The 694 individuals identified with AF/fibrosis who had at least 3 generations of genealogy data were found to have significantly elevated pairwise relatedness (p < 0.001), even when first- and second-degree relationships were ignored (p < 0.001). Significantly elevated risks for AF/fibrosis among first- (relative risk [RR]: 4.65), second- (RR: 3.14), and third-degree (RR: 2.70) relatives of individuals with AF/fibrosis were observed. We identified 157 extended Utah pedigrees with a significant excess of AF/fibrosis among descendants.
There is a strong heritable contribution to predisposition to AF co-occurring with fibrosis. We suggest that this study provides a unique foundation for a search for predisposition genes, specifically for AF co-occurring with fibrosis.
[Display omitted] |
| doi_str_mv | 10.1016/j.jacep.2019.01.002 |
| format | Article |
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Although a heritable contribution to AF is well-established and the association of fibrosis with AF is well-recognized, no studies have analyzed the genetic contribution to AF co-occurring with fibrosis.
AF patients with magnetic resonance imaging–confirmed fibrosis were identified in a population-based health sciences center database linked to a Utah genealogy. Familial clustering of AF/fibrosis was defined by analysis of pairwise case relatedness, estimation of relative risk of AF/fibrosis in relatives, and identification of high-risk AF/fibrosis pedigrees.
The 694 individuals identified with AF/fibrosis who had at least 3 generations of genealogy data were found to have significantly elevated pairwise relatedness (p < 0.001), even when first- and second-degree relationships were ignored (p < 0.001). Significantly elevated risks for AF/fibrosis among first- (relative risk [RR]: 4.65), second- (RR: 3.14), and third-degree (RR: 2.70) relatives of individuals with AF/fibrosis were observed. We identified 157 extended Utah pedigrees with a significant excess of AF/fibrosis among descendants.
There is a strong heritable contribution to predisposition to AF co-occurring with fibrosis. We suggest that this study provides a unique foundation for a search for predisposition genes, specifically for AF co-occurring with fibrosis.
[Display omitted]</description><identifier>ISSN: 2405-500X</identifier><identifier>EISSN: 2405-5018</identifier><identifier>DOI: 10.1016/j.jacep.2019.01.002</identifier><identifier>PMID: 31000104</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>atrial fibrillation ; atrial fibrosis ; heritable ; pedigree ; Utah Population Database</subject><ispartof>JACC. Clinical electrophysiology, 2019-04, Vol.5 (4), p.493-500</ispartof><rights>2019 American College of Cardiology Foundation</rights><rights>Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-ac88ea1fa7f39853257a43ec42829728da0b9e6e8bd156fab5b1aa6f975b91063</citedby><cites>FETCH-LOGICAL-c404t-ac88ea1fa7f39853257a43ec42829728da0b9e6e8bd156fab5b1aa6f975b91063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31000104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, Brent D.</creatorcontrib><creatorcontrib>Wasmund, Stephen L.</creatorcontrib><creatorcontrib>Sachse, Frank B.</creatorcontrib><creatorcontrib>Kaur, Gagandeep</creatorcontrib><creatorcontrib>Marrouche, Nassir F.</creatorcontrib><creatorcontrib>Cannon-Albright, Lisa A.</creatorcontrib><title>Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis</title><title>JACC. Clinical electrophysiology</title><addtitle>JACC Clin Electrophysiol</addtitle><description>The aim of this study was to define the population-based familial clustering of atrial fibrillation (AF) that is associated with fibrosis and describe evidence for a heritable predisposition.
Although a heritable contribution to AF is well-established and the association of fibrosis with AF is well-recognized, no studies have analyzed the genetic contribution to AF co-occurring with fibrosis.
AF patients with magnetic resonance imaging–confirmed fibrosis were identified in a population-based health sciences center database linked to a Utah genealogy. Familial clustering of AF/fibrosis was defined by analysis of pairwise case relatedness, estimation of relative risk of AF/fibrosis in relatives, and identification of high-risk AF/fibrosis pedigrees.
The 694 individuals identified with AF/fibrosis who had at least 3 generations of genealogy data were found to have significantly elevated pairwise relatedness (p < 0.001), even when first- and second-degree relationships were ignored (p < 0.001). Significantly elevated risks for AF/fibrosis among first- (relative risk [RR]: 4.65), second- (RR: 3.14), and third-degree (RR: 2.70) relatives of individuals with AF/fibrosis were observed. We identified 157 extended Utah pedigrees with a significant excess of AF/fibrosis among descendants.
There is a strong heritable contribution to predisposition to AF co-occurring with fibrosis. We suggest that this study provides a unique foundation for a search for predisposition genes, specifically for AF co-occurring with fibrosis.
[Display omitted]</description><subject>atrial fibrillation</subject><subject>atrial fibrosis</subject><subject>heritable</subject><subject>pedigree</subject><subject>Utah Population Database</subject><issn>2405-500X</issn><issn>2405-5018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kM9OwzAMxiMEAgR7AiTUI5cVO2269sBhmvgnIXEBjVuUpK7I1C0jyZB4G55lT0bKgCMn28ln-_OPsTOEHAGry0W-UIbWOQdscsAcgO-xY16CGAvAev8vh5cjNgphAQAoeM2xPGRHBQ4llMdsfv1uW1oZyjrnM5XdkbdR6Z6ymVtFb_UmWrfKott-TlOp-uzGam_7Xn2_T0NwxqpIbTa38XX7Ofy6YMMpO-hUH2j0E0_Y88310-xu_PB4ez-bPoxNCWUcK1PXpLBTk65oalFwMVFlQaZMTpsJr1sFuqGKat2iqDqlhUalqq6ZCN0gVMUJu9jNXXv3tqEQ5dIGQ8nfitwmSM4RGzGcm6TFTmqSw-Cpk2tvl8p_SAQ5QJUL-Q1VDlAloExQU9f5z4KNXlL71_OLMAmudgJKZ75b8jIYOxBtrScTZevsvwu-AJL5inI</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Wilson, Brent D.</creator><creator>Wasmund, Stephen L.</creator><creator>Sachse, Frank B.</creator><creator>Kaur, Gagandeep</creator><creator>Marrouche, Nassir F.</creator><creator>Cannon-Albright, Lisa A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201904</creationdate><title>Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis</title><author>Wilson, Brent D. ; Wasmund, Stephen L. ; Sachse, Frank B. ; Kaur, Gagandeep ; Marrouche, Nassir F. ; Cannon-Albright, Lisa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-ac88ea1fa7f39853257a43ec42829728da0b9e6e8bd156fab5b1aa6f975b91063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>atrial fibrillation</topic><topic>atrial fibrosis</topic><topic>heritable</topic><topic>pedigree</topic><topic>Utah Population Database</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Brent D.</creatorcontrib><creatorcontrib>Wasmund, Stephen L.</creatorcontrib><creatorcontrib>Sachse, Frank B.</creatorcontrib><creatorcontrib>Kaur, Gagandeep</creatorcontrib><creatorcontrib>Marrouche, Nassir F.</creatorcontrib><creatorcontrib>Cannon-Albright, Lisa A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JACC. Clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Brent D.</au><au>Wasmund, Stephen L.</au><au>Sachse, Frank B.</au><au>Kaur, Gagandeep</au><au>Marrouche, Nassir F.</au><au>Cannon-Albright, Lisa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis</atitle><jtitle>JACC. Clinical electrophysiology</jtitle><addtitle>JACC Clin Electrophysiol</addtitle><date>2019-04</date><risdate>2019</risdate><volume>5</volume><issue>4</issue><spage>493</spage><epage>500</epage><pages>493-500</pages><issn>2405-500X</issn><eissn>2405-5018</eissn><abstract>The aim of this study was to define the population-based familial clustering of atrial fibrillation (AF) that is associated with fibrosis and describe evidence for a heritable predisposition.
Although a heritable contribution to AF is well-established and the association of fibrosis with AF is well-recognized, no studies have analyzed the genetic contribution to AF co-occurring with fibrosis.
AF patients with magnetic resonance imaging–confirmed fibrosis were identified in a population-based health sciences center database linked to a Utah genealogy. Familial clustering of AF/fibrosis was defined by analysis of pairwise case relatedness, estimation of relative risk of AF/fibrosis in relatives, and identification of high-risk AF/fibrosis pedigrees.
The 694 individuals identified with AF/fibrosis who had at least 3 generations of genealogy data were found to have significantly elevated pairwise relatedness (p < 0.001), even when first- and second-degree relationships were ignored (p < 0.001). Significantly elevated risks for AF/fibrosis among first- (relative risk [RR]: 4.65), second- (RR: 3.14), and third-degree (RR: 2.70) relatives of individuals with AF/fibrosis were observed. We identified 157 extended Utah pedigrees with a significant excess of AF/fibrosis among descendants.
There is a strong heritable contribution to predisposition to AF co-occurring with fibrosis. We suggest that this study provides a unique foundation for a search for predisposition genes, specifically for AF co-occurring with fibrosis.
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| ispartof | JACC. Clinical electrophysiology, 2019-04, Vol.5 (4), p.493-500 |
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| language | eng |
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| source | Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | atrial fibrillation atrial fibrosis heritable pedigree Utah Population Database |
| title | Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis |
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