Imiquimod enhances DNFB mediated contact hypersensitivity in mice

Imiquimod (Imiq) is a synthetic imizoquinoline compound which can act on Toll-like receptor (TLR)7 and transduce signals involved in cell activation. We investigated the role of Imiq on contact hypersensitivity (CHS) and explored the potential mechanisms of mast cells involved in the process. Topica...

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Veröffentlicht in:	International immunopharmacology 2019-07, Vol.72, p.284-291
Hauptverfasser:	Ren, Shurong, Wang, Qiubo, Zhang, Yanli, Zhang, Bei, Zhao, Chunru, Dong, Xue, Song, Yancheng, Zhang, Wendi, Qin, Xianfei, Liu, Mingyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - toxicity Administration, Topical Allergens Animals Cell activation Cell proliferation Cell Proliferation - drug effects Cimetidine Contact dermatitis Contact hypersensitivity Degranulation Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dermatitis, Contact - immunology Dinitrofluorobenzene Female Histamine Histamine - immunology Homing Hypersensitivity Imiquimod Imiquimod - toxicity Immune system Lymph nodes Lymph Nodes - drug effects Lymph Nodes - immunology Mast cell degranulation Mast cells Mast Cells - drug effects Mast Cells - immunology Mice Mice, Inbred C57BL mRNA Peritoneum Proteins Pyrilamine Skin Spleen Spleen - cytology TLR7 protein Toll-like receptors Toluidine Toluidine blue Topical application
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