PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro

Fine particulate matter (PM2.5) has been closely linked to increased morbidity and mortality of lung cancer worldwide. However, the role of PM2.5 in the etiology of lung cancer and the mechanism involved in PM2.5 induced lung cancer are largely unknown. In this study, we performed chronic exposure a...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2019-08, Vol.178, p.159-167
Hauptverfasser:	Wang, Yunxia, Zhong, Yijue, Hou, Tianfang, Liao, Jiping, Zhang, Cheng, Sun, Chao, Wang, Guangfa
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Air Pollutants - toxicity Animals Cancer stem cells Cell Survival Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Fine particulate matter Humans Lung - drug effects Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice, Inbred BALB C Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Notch1 Particulate Matter - toxicity Receptor, Notch1 - metabolism Signal Transduction
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