Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study
Cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients. VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). To date, in this s...
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| Veröffentlicht in: | Diabetes research and clinical practice 2019-05, Vol.151, p.152-162 |
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| creator | Sardu, Celestino Paolisso, Pasquale Santamaria, Matteo Sacra, Cosimo Pieretti, Gorizio Rizzo, Maria Rosaria Barbieri, Michelangela Scisciola, Lucia Nicoletti, Gianfranco Paolisso, Giuseppe Marfella, Raffaele |
| description | Cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.
VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). To date, in this study we investigated the correlation between HRV alterations and VVS recurrence at 12 months of follow up in T2DM vs. non T2DM patients.
In a prospective multicenter study we studied a propensity score matching (PSM) analysis of 121 T2DM vs. 121 non T2DM patients affected by VVS.
T2DM vs. non T2DM patients had at baseline a higher rate of HRV dysfunction, and this was linked to higher rate of VVS recurrence at 12 months of follow up (p |
| doi_str_mv | 10.1016/j.diabres.2019.04.015 |
| format | Article |
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VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). To date, in this study we investigated the correlation between HRV alterations and VVS recurrence at 12 months of follow up in T2DM vs. non T2DM patients.
In a prospective multicenter study we studied a propensity score matching (PSM) analysis of 121 T2DM vs. 121 non T2DM patients affected by VVS.
T2DM vs. non T2DM patients had at baseline a higher rate of HRV dysfunction, and this was linked to higher rate of VVS recurrence at 12 months of follow up (p < 0.05). Blood pressure alterations and lower LF/HF ratio were linked to higher rate of all cause syncope recurrence, and of vasodepressor, cardio inhibitory, and mixed syncope recurrence (p < 0.05). Anti hypertensive drug therapies increased the number of vasodepressor and mixed syncope events (p < 0.05); alterations of heart rate increased syncope recurrence and mixed syncope recurrence events (p < 0.05). Finally, T2DM was linked to higher rate of VVS recurrence, and specifically of vasodepressor and mixed VVS recurrence (p < 0.05).
T2DM patients have alterations of the autonomic nervous system, as result of cardiac autonomic neuropathy. However, T2DM diagnosis and autonomic dysfunction assessed by HRV alterations predicted VVS recurrence.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2019.04.015</identifier><identifier>PMID: 31004672</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Cardiac autonomic dysfunction ; Type 2 diabetes mellitus ; Vaso vagal syncope</subject><ispartof>Diabetes research and clinical practice, 2019-05, Vol.151, p.152-162</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-541f4d20e0b621d0df7bc53e7d05b073d769f599c342bd6a43699103cbc588d3</citedby><cites>FETCH-LOGICAL-c365t-541f4d20e0b621d0df7bc53e7d05b073d769f599c342bd6a43699103cbc588d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822719302578$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31004672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sardu, Celestino</creatorcontrib><creatorcontrib>Paolisso, Pasquale</creatorcontrib><creatorcontrib>Santamaria, Matteo</creatorcontrib><creatorcontrib>Sacra, Cosimo</creatorcontrib><creatorcontrib>Pieretti, Gorizio</creatorcontrib><creatorcontrib>Rizzo, Maria Rosaria</creatorcontrib><creatorcontrib>Barbieri, Michelangela</creatorcontrib><creatorcontrib>Scisciola, Lucia</creatorcontrib><creatorcontrib>Nicoletti, Gianfranco</creatorcontrib><creatorcontrib>Paolisso, Giuseppe</creatorcontrib><creatorcontrib>Marfella, Raffaele</creatorcontrib><title>Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.
VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). To date, in this study we investigated the correlation between HRV alterations and VVS recurrence at 12 months of follow up in T2DM vs. non T2DM patients.
In a prospective multicenter study we studied a propensity score matching (PSM) analysis of 121 T2DM vs. 121 non T2DM patients affected by VVS.
T2DM vs. non T2DM patients had at baseline a higher rate of HRV dysfunction, and this was linked to higher rate of VVS recurrence at 12 months of follow up (p < 0.05). Blood pressure alterations and lower LF/HF ratio were linked to higher rate of all cause syncope recurrence, and of vasodepressor, cardio inhibitory, and mixed syncope recurrence (p < 0.05). Anti hypertensive drug therapies increased the number of vasodepressor and mixed syncope events (p < 0.05); alterations of heart rate increased syncope recurrence and mixed syncope recurrence events (p < 0.05). Finally, T2DM was linked to higher rate of VVS recurrence, and specifically of vasodepressor and mixed VVS recurrence (p < 0.05).
T2DM patients have alterations of the autonomic nervous system, as result of cardiac autonomic neuropathy. However, T2DM diagnosis and autonomic dysfunction assessed by HRV alterations predicted VVS recurrence.</description><subject>Cardiac autonomic dysfunction</subject><subject>Type 2 diabetes mellitus</subject><subject>Vaso vagal syncope</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkF1P2zAUhq0JtJZuP2HIl9w0O_5InHAzVdUGk5AmQcWtldgnw1WTFNtByr_HpYVd7spH9nPO6_MQ8o1BxoAV37eZdXXjMWQcWJWBzIDln8iclYovS87VGZknrnyrZ-QihC0AFELmn8lMMABZKD4n3br2aZChYerNsEfq0YzeY2-Qup7GKV1xeojCiIF2uNu5OAa6r6PDPgb6EjLaD74b_u4mg50z_96u6eYJ6Xp1_7h6oCGOdvpCztt6F_Dr6VyQza-fm_Xt8u7Pze_16m5pRJHHZS5ZKy0HhKbgzIJtVWNygcpC3oASVhVVm1eVEZI3tqilKKqKgTCJKksrFuTqOHbvh-cRQ9SdCyZ9ve5xGIPmnLFKlkqJhOZH1PghBI-t3nvX1X7SDPRBtN7qk2h9EK1B6iQ69V2eIsamQ_vR9W42AT-OAKY9Xxx6HYw7aLUuKY7aDu4_Ea8yBpII</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Sardu, Celestino</creator><creator>Paolisso, Pasquale</creator><creator>Santamaria, Matteo</creator><creator>Sacra, Cosimo</creator><creator>Pieretti, Gorizio</creator><creator>Rizzo, Maria Rosaria</creator><creator>Barbieri, Michelangela</creator><creator>Scisciola, Lucia</creator><creator>Nicoletti, Gianfranco</creator><creator>Paolisso, Giuseppe</creator><creator>Marfella, Raffaele</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201905</creationdate><title>Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study</title><author>Sardu, Celestino ; Paolisso, Pasquale ; Santamaria, Matteo ; Sacra, Cosimo ; Pieretti, Gorizio ; Rizzo, Maria Rosaria ; Barbieri, Michelangela ; Scisciola, Lucia ; Nicoletti, Gianfranco ; Paolisso, Giuseppe ; Marfella, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-541f4d20e0b621d0df7bc53e7d05b073d769f599c342bd6a43699103cbc588d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cardiac autonomic dysfunction</topic><topic>Type 2 diabetes mellitus</topic><topic>Vaso vagal syncope</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sardu, Celestino</creatorcontrib><creatorcontrib>Paolisso, Pasquale</creatorcontrib><creatorcontrib>Santamaria, Matteo</creatorcontrib><creatorcontrib>Sacra, Cosimo</creatorcontrib><creatorcontrib>Pieretti, Gorizio</creatorcontrib><creatorcontrib>Rizzo, Maria Rosaria</creatorcontrib><creatorcontrib>Barbieri, Michelangela</creatorcontrib><creatorcontrib>Scisciola, Lucia</creatorcontrib><creatorcontrib>Nicoletti, Gianfranco</creatorcontrib><creatorcontrib>Paolisso, Giuseppe</creatorcontrib><creatorcontrib>Marfella, Raffaele</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sardu, Celestino</au><au>Paolisso, Pasquale</au><au>Santamaria, Matteo</au><au>Sacra, Cosimo</au><au>Pieretti, Gorizio</au><au>Rizzo, Maria Rosaria</au><au>Barbieri, Michelangela</au><au>Scisciola, Lucia</au><au>Nicoletti, Gianfranco</au><au>Paolisso, Giuseppe</au><au>Marfella, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2019-05</date><risdate>2019</risdate><volume>151</volume><spage>152</spage><epage>162</epage><pages>152-162</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.
VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). To date, in this study we investigated the correlation between HRV alterations and VVS recurrence at 12 months of follow up in T2DM vs. non T2DM patients.
In a prospective multicenter study we studied a propensity score matching (PSM) analysis of 121 T2DM vs. 121 non T2DM patients affected by VVS.
T2DM vs. non T2DM patients had at baseline a higher rate of HRV dysfunction, and this was linked to higher rate of VVS recurrence at 12 months of follow up (p < 0.05). Blood pressure alterations and lower LF/HF ratio were linked to higher rate of all cause syncope recurrence, and of vasodepressor, cardio inhibitory, and mixed syncope recurrence (p < 0.05). Anti hypertensive drug therapies increased the number of vasodepressor and mixed syncope events (p < 0.05); alterations of heart rate increased syncope recurrence and mixed syncope recurrence events (p < 0.05). Finally, T2DM was linked to higher rate of VVS recurrence, and specifically of vasodepressor and mixed VVS recurrence (p < 0.05).
T2DM patients have alterations of the autonomic nervous system, as result of cardiac autonomic neuropathy. However, T2DM diagnosis and autonomic dysfunction assessed by HRV alterations predicted VVS recurrence.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31004672</pmid><doi>10.1016/j.diabres.2019.04.015</doi><tpages>11</tpages></addata></record> |
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| subjects | Cardiac autonomic dysfunction Type 2 diabetes mellitus Vaso vagal syncope |
| title | Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study |
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