Inhibition of GIP signaling extends lifespan without caloric restriction

Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-depende...

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Veröffentlicht in:Biochemical and biophysical research communications 2019-06, Vol.513 (4), p.974-982
Hauptverfasser: Hoizumi, Manabu, Sato, Takehiro, Shimizu, Tatsunori, Kato, Shunsuke, Tsukiyama, Katsushi, Narita, Takuma, Fujita, Hiroki, Morii, Tsukasa, Sassa, Mariko Harada, Seino, Yutaka, Yamada, Yuichiro
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Sprache:eng
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