HIV co-infection in HTLV-1 carriers in Spain
Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants fr...
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| Veröffentlicht in: | Virus research 2019-06, Vol.266, p.48-51 |
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| creator | de Mendoza, Carmen Caballero, Estrella Aguilera, Antonio Benito, Rafael Maciá, Dolores García-Costa, Juan Soriano, Vicente |
| description | Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain.
A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection.
Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia).
HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non-Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection.
HIV coinfection is infrequent ( |
| doi_str_mv | 10.1016/j.virusres.2019.04.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2211944931</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168170219301704</els_id><sourcerecordid>2211944931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-1303e7d17ecec0122f5cf2a4edeafe835b835bcd35ab219378d9bd94b458e1fc3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMotlb_QtmjB3fNJNmP3JSitlDwYO01ZJNZSGl3a9It-O_N0urVwzAwPO8M8xAyBZoBheJxkx2d74PHkDEKMqMio1RckDFUJUtLIdklGUewSqGkbERuQthQSgteFtdkxKmUlcz5mDzMF-vEdKlrGzQH17WJa5P5arlOITHae4c-DKOPvXbtLblq9Dbg3blPyOfry2o2T5fvb4vZ8zI1vKgOKXDKsbRQokFDgbEmNw3TAi3qBiue10MZy3NdM5C8rKysrRS1yCuExvAJuT_t3fvuq8dwUDsXDG63usWuD4oxACmE5BDR4oQa34Woo1F773bafyugajClNurXlBpMKSpUNBWD0_ONvt6h_Yv9qonA0wnA-OkxelDBOGwNWuejKmU799-NH53qfDM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2211944931</pqid></control><display><type>article</type><title>HIV co-infection in HTLV-1 carriers in Spain</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>de Mendoza, Carmen ; Caballero, Estrella ; Aguilera, Antonio ; Benito, Rafael ; Maciá, Dolores ; García-Costa, Juan ; Soriano, Vicente</creator><creatorcontrib>de Mendoza, Carmen ; Caballero, Estrella ; Aguilera, Antonio ; Benito, Rafael ; Maciá, Dolores ; García-Costa, Juan ; Soriano, Vicente ; on behalf of the Spanish HTLV Network ; Spanish HTLV Network</creatorcontrib><description>Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain.
A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection.
Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia).
HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non-Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection.
HIV coinfection is infrequent (<5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.</description><identifier>ISSN: 0168-1702</identifier><identifier>EISSN: 1872-7492</identifier><identifier>DOI: 10.1016/j.virusres.2019.04.004</identifier><identifier>PMID: 30998953</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Adult T-cell leukemia ; AIDS ; Antiretroviral therapy ; Carrier State - epidemiology ; Carrier State - pathology ; Carrier State - physiopathology ; Carrier State - virology ; Co-infection ; Coinfection - epidemiology ; Coinfection - virology ; Emigrants and Immigrants ; Epidemiology ; Female ; HIV ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - isolation & purification ; HTLV ; HTLV-I Infections - epidemiology ; HTLV-I Infections - pathology ; HTLV-I Infections - physiopathology ; HTLV-I Infections - virology ; Human T-lymphotropic virus 1 - isolation & purification ; Humans ; Late diagnosis ; Male ; Middle Aged ; Registries ; Risk Factors ; Spain - epidemiology ; Tropical spastic paraparesis</subject><ispartof>Virus research, 2019-06, Vol.266, p.48-51</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1303e7d17ecec0122f5cf2a4edeafe835b835bcd35ab219378d9bd94b458e1fc3</citedby><cites>FETCH-LOGICAL-c368t-1303e7d17ecec0122f5cf2a4edeafe835b835bcd35ab219378d9bd94b458e1fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168170219301704$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30998953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Mendoza, Carmen</creatorcontrib><creatorcontrib>Caballero, Estrella</creatorcontrib><creatorcontrib>Aguilera, Antonio</creatorcontrib><creatorcontrib>Benito, Rafael</creatorcontrib><creatorcontrib>Maciá, Dolores</creatorcontrib><creatorcontrib>García-Costa, Juan</creatorcontrib><creatorcontrib>Soriano, Vicente</creatorcontrib><creatorcontrib>on behalf of the Spanish HTLV Network</creatorcontrib><creatorcontrib>Spanish HTLV Network</creatorcontrib><title>HIV co-infection in HTLV-1 carriers in Spain</title><title>Virus research</title><addtitle>Virus Res</addtitle><description>Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain.
A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection.
Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia).
HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non-Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection.
HIV coinfection is infrequent (<5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.</description><subject>Adult</subject><subject>Adult T-cell leukemia</subject><subject>AIDS</subject><subject>Antiretroviral therapy</subject><subject>Carrier State - epidemiology</subject><subject>Carrier State - pathology</subject><subject>Carrier State - physiopathology</subject><subject>Carrier State - virology</subject><subject>Co-infection</subject><subject>Coinfection - epidemiology</subject><subject>Coinfection - virology</subject><subject>Emigrants and Immigrants</subject><subject>Epidemiology</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - isolation & purification</subject><subject>HTLV</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-I Infections - pathology</subject><subject>HTLV-I Infections - physiopathology</subject><subject>HTLV-I Infections - virology</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Humans</subject><subject>Late diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Tropical spastic paraparesis</subject><issn>0168-1702</issn><issn>1872-7492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_QtmjB3fNJNmP3JSitlDwYO01ZJNZSGl3a9It-O_N0urVwzAwPO8M8xAyBZoBheJxkx2d74PHkDEKMqMio1RckDFUJUtLIdklGUewSqGkbERuQthQSgteFtdkxKmUlcz5mDzMF-vEdKlrGzQH17WJa5P5arlOITHae4c-DKOPvXbtLblq9Dbg3blPyOfry2o2T5fvb4vZ8zI1vKgOKXDKsbRQokFDgbEmNw3TAi3qBiue10MZy3NdM5C8rKysrRS1yCuExvAJuT_t3fvuq8dwUDsXDG63usWuD4oxACmE5BDR4oQa34Woo1F773bafyugajClNurXlBpMKSpUNBWD0_ONvt6h_Yv9qonA0wnA-OkxelDBOGwNWuejKmU799-NH53qfDM</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>de Mendoza, Carmen</creator><creator>Caballero, Estrella</creator><creator>Aguilera, Antonio</creator><creator>Benito, Rafael</creator><creator>Maciá, Dolores</creator><creator>García-Costa, Juan</creator><creator>Soriano, Vicente</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201906</creationdate><title>HIV co-infection in HTLV-1 carriers in Spain</title><author>de Mendoza, Carmen ; Caballero, Estrella ; Aguilera, Antonio ; Benito, Rafael ; Maciá, Dolores ; García-Costa, Juan ; Soriano, Vicente</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1303e7d17ecec0122f5cf2a4edeafe835b835bcd35ab219378d9bd94b458e1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Adult T-cell leukemia</topic><topic>AIDS</topic><topic>Antiretroviral therapy</topic><topic>Carrier State - epidemiology</topic><topic>Carrier State - pathology</topic><topic>Carrier State - physiopathology</topic><topic>Carrier State - virology</topic><topic>Co-infection</topic><topic>Coinfection - epidemiology</topic><topic>Coinfection - virology</topic><topic>Emigrants and Immigrants</topic><topic>Epidemiology</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - isolation & purification</topic><topic>HTLV</topic><topic>HTLV-I Infections - epidemiology</topic><topic>HTLV-I Infections - pathology</topic><topic>HTLV-I Infections - physiopathology</topic><topic>HTLV-I Infections - virology</topic><topic>Human T-lymphotropic virus 1 - isolation & purification</topic><topic>Humans</topic><topic>Late diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Tropical spastic paraparesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Mendoza, Carmen</creatorcontrib><creatorcontrib>Caballero, Estrella</creatorcontrib><creatorcontrib>Aguilera, Antonio</creatorcontrib><creatorcontrib>Benito, Rafael</creatorcontrib><creatorcontrib>Maciá, Dolores</creatorcontrib><creatorcontrib>García-Costa, Juan</creatorcontrib><creatorcontrib>Soriano, Vicente</creatorcontrib><creatorcontrib>on behalf of the Spanish HTLV Network</creatorcontrib><creatorcontrib>Spanish HTLV Network</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virus research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Mendoza, Carmen</au><au>Caballero, Estrella</au><au>Aguilera, Antonio</au><au>Benito, Rafael</au><au>Maciá, Dolores</au><au>García-Costa, Juan</au><au>Soriano, Vicente</au><aucorp>on behalf of the Spanish HTLV Network</aucorp><aucorp>Spanish HTLV Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV co-infection in HTLV-1 carriers in Spain</atitle><jtitle>Virus research</jtitle><addtitle>Virus Res</addtitle><date>2019-06</date><risdate>2019</risdate><volume>266</volume><spage>48</spage><epage>51</epage><pages>48-51</pages><issn>0168-1702</issn><eissn>1872-7492</eissn><abstract>Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain.
A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection.
Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia).
HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non-Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection.
HIV coinfection is infrequent (<5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30998953</pmid><doi>10.1016/j.virusres.2019.04.004</doi><tpages>4</tpages></addata></record> |
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| ispartof | Virus research, 2019-06, Vol.266, p.48-51 |
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| subjects | Adult Adult T-cell leukemia AIDS Antiretroviral therapy Carrier State - epidemiology Carrier State - pathology Carrier State - physiopathology Carrier State - virology Co-infection Coinfection - epidemiology Coinfection - virology Emigrants and Immigrants Epidemiology Female HIV HIV Infections - epidemiology HIV Infections - virology HIV-1 - isolation & purification HTLV HTLV-I Infections - epidemiology HTLV-I Infections - pathology HTLV-I Infections - physiopathology HTLV-I Infections - virology Human T-lymphotropic virus 1 - isolation & purification Humans Late diagnosis Male Middle Aged Registries Risk Factors Spain - epidemiology Tropical spastic paraparesis |
| title | HIV co-infection in HTLV-1 carriers in Spain |
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