Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system

The blood-brain barrier (BBB) is involved in the pathogeneses of ischemic stroke (IS). Geniposide (GEN), an iridoid glycoside isolated from Gardenia jasminoides Ellis, has been used for the treatment of IS. However, the effects of GEN on the BBB are poorly understood. In vitro disease models of the...

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Veröffentlicht in:	European journal of pharmacology 2019-07, Vol.854, p.224-231
Hauptverfasser:	Li, Changxiang, Wang, Xueqian, Cheng, Fafeng, Du, Xin, Yan, Juntang, Zhai, Changming, Mu, Jie, Wang, Qingguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-apoptotic Anti-inflammatory Geniposide In vitro blood-brain barrier Oxygen glucose deprivation and reoxygenation Tight junction
Online-Zugang:	Volltext
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