Peptide Oligomerization Memory Effects and Their Impact on the Physical Stability of the GLP‑1 Agonist Liraglutide

Peptides and proteins commonly have complex structural landscapes allowing for transformation into a wide array of species including oligomers, aggregates, and fibrils. The formation of undesirable forms including aggregates and fibrils poses serious risks from the perspective of drug development an...

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Veröffentlicht in:Molecular pharmaceutics 2019-05, Vol.16 (5), p.2153-2161
Hauptverfasser: Bothe, Jameson R, Andrews, Alexandra, Smith, Katelyn J, Joyce, Leo A, Krishnamachari, Yogita, Kashi, Sandhya
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Sprache:eng
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