Alpha‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats
Objectives Effect of alpha‐linolenic acid (ALA) against ovalbumin (OVA)‐induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat. Methods Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pa...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2019-07, Vol.71 (7), p.1089-1099 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Boskabady, Mohammad Hossein Kaveh, Mahsa Shakeri, Farzaneh Mohammadian Roshan, Nama Rezaee, Ramin |
| description | Objectives
Effect of alpha‐linolenic acid (ALA) against ovalbumin (OVA)‐induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.
Methods
Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone.
Key findings
As compared to group C, in OVA‐sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO2 and NO3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage.
Conclusions
Alpha‐linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma. |
| doi_str_mv | 10.1111/jphp.13094 |
| format | Article |
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Effect of alpha‐linolenic acid (ALA) against ovalbumin (OVA)‐induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.
Methods
Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone.
Key findings
As compared to group C, in OVA‐sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO2 and NO3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage.
Conclusions
Alpha‐linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.13094</identifier><identifier>PMID: 30993723</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>alpha-Linolenic Acid - pharmacology ; alpha‐linolenic acid ; Alveoli ; Animals ; Antioxidants ; Asthma ; Asthma - drug therapy ; bronchial asthma ; Bronchoalveolar Lavage Fluid ; Bronchus ; Dexamethasone ; Dexamethasone - pharmacology ; Emphysema ; Fibrosis ; Fibrosis - drug therapy ; Inflammation ; Inflammation - pathology ; Inflammatory diseases ; Leukocyte Count ; Leukocytes (eosinophilic) ; Linolenic acid ; Lung - pathology ; lung inflammation ; Lungs ; Male ; Medical treatment ; Monocytes ; Nitrogen dioxide ; Ovalbumin ; Ovalbumin - pharmacology ; ovalbumin‐sensitized rats ; Oxidative stress ; Rats ; Rats, Wistar ; Respiratory tract ; Respiratory tract diseases ; Rodents ; Superoxide Dismutase</subject><ispartof>Journal of pharmacy and pharmacology, 2019-07, Vol.71 (7), p.1089-1099</ispartof><rights>2019 Royal Pharmaceutical Society</rights><rights>2019 Royal Pharmaceutical Society.</rights><rights>Copyright © 2019 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-6a097c9dc1085732f237186a46b2a3700d644dfc322b3a28b6211eeed50315763</citedby><cites>FETCH-LOGICAL-c3574-6a097c9dc1085732f237186a46b2a3700d644dfc322b3a28b6211eeed50315763</cites><orcidid>0000-0001-5736-9755</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.13094$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.13094$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30993723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><creatorcontrib>Kaveh, Mahsa</creatorcontrib><creatorcontrib>Shakeri, Farzaneh</creatorcontrib><creatorcontrib>Mohammadian Roshan, Nama</creatorcontrib><creatorcontrib>Rezaee, Ramin</creatorcontrib><title>Alpha‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives
Effect of alpha‐linolenic acid (ALA) against ovalbumin (OVA)‐induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.
Methods
Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone.
Key findings
As compared to group C, in OVA‐sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO2 and NO3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage.
Conclusions
Alpha‐linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma.</description><subject>alpha-Linolenic Acid - pharmacology</subject><subject>alpha‐linolenic acid</subject><subject>Alveoli</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>bronchial asthma</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchus</subject><subject>Dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Emphysema</subject><subject>Fibrosis</subject><subject>Fibrosis - drug therapy</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Inflammatory diseases</subject><subject>Leukocyte Count</subject><subject>Leukocytes (eosinophilic)</subject><subject>Linolenic acid</subject><subject>Lung - pathology</subject><subject>lung inflammation</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Monocytes</subject><subject>Nitrogen dioxide</subject><subject>Ovalbumin</subject><subject>Ovalbumin - pharmacology</subject><subject>ovalbumin‐sensitized rats</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Rodents</subject><subject>Superoxide Dismutase</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAURoMozji68QGk4EaEjvlp03YpgzrKgLPQlYuQpinNkDY1aZVx5SP4jD6JGTu6cGHgksU99_DxAXCM4BT5d7Fqq3aKCMyiHTDGMMJhguJ0F4whxDgkcUJG4MC5FYQwoZTug5FnM5JgMgZPl7qt-Of7h1aN0bJRIuBCFQGvpVbG8k66ILemEZXiOuCuq2oelJJ3vfUb1QTmheu8r1XjHU42TnXqTRaBv3SHYK_k2smj7T8Bj9dXD7N5uLi_uZ1dLkLhs0Uh5TBLRFYIBFOfFZeYJCilPKI55iSBsKBRVJSCYJwTjtOcYoSklEUMCYoTSibgbPC21jz30nWsVk5IrXkjTe8YxghmcYwy4tHTP-jK9Lbx6TxFKMz8bITnAyWscc7KkrVW1dyuGYJsUznbVM6-K_fwyVbZ57UsftGfjj2ABuBVabn-R8XulvPlIP0C3wONFg</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Boskabady, Mohammad Hossein</creator><creator>Kaveh, Mahsa</creator><creator>Shakeri, Farzaneh</creator><creator>Mohammadian Roshan, Nama</creator><creator>Rezaee, Ramin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5736-9755</orcidid></search><sort><creationdate>201907</creationdate><title>Alpha‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats</title><author>Boskabady, Mohammad Hossein ; Kaveh, Mahsa ; Shakeri, Farzaneh ; Mohammadian Roshan, Nama ; Rezaee, Ramin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-6a097c9dc1085732f237186a46b2a3700d644dfc322b3a28b6211eeed50315763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>alpha-Linolenic Acid - pharmacology</topic><topic>alpha‐linolenic acid</topic><topic>Alveoli</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>bronchial asthma</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchus</topic><topic>Dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Emphysema</topic><topic>Fibrosis</topic><topic>Fibrosis - drug therapy</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Inflammatory diseases</topic><topic>Leukocyte Count</topic><topic>Leukocytes (eosinophilic)</topic><topic>Linolenic acid</topic><topic>Lung - pathology</topic><topic>lung inflammation</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Monocytes</topic><topic>Nitrogen dioxide</topic><topic>Ovalbumin</topic><topic>Ovalbumin - pharmacology</topic><topic>ovalbumin‐sensitized rats</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Respiratory tract</topic><topic>Respiratory tract diseases</topic><topic>Rodents</topic><topic>Superoxide Dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boskabady, Mohammad Hossein</creatorcontrib><creatorcontrib>Kaveh, Mahsa</creatorcontrib><creatorcontrib>Shakeri, Farzaneh</creatorcontrib><creatorcontrib>Mohammadian Roshan, Nama</creatorcontrib><creatorcontrib>Rezaee, Ramin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boskabady, Mohammad Hossein</au><au>Kaveh, Mahsa</au><au>Shakeri, Farzaneh</au><au>Mohammadian Roshan, Nama</au><au>Rezaee, Ramin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>71</volume><issue>7</issue><spage>1089</spage><epage>1099</epage><pages>1089-1099</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Objectives
Effect of alpha‐linolenic acid (ALA) against ovalbumin (OVA)‐induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.
Methods
Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone.
Key findings
As compared to group C, in OVA‐sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO2 and NO3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage.
Conclusions
Alpha‐linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30993723</pmid><doi>10.1111/jphp.13094</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5736-9755</orcidid></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals |
| subjects | alpha-Linolenic Acid - pharmacology alpha‐linolenic acid Alveoli Animals Antioxidants Asthma Asthma - drug therapy bronchial asthma Bronchoalveolar Lavage Fluid Bronchus Dexamethasone Dexamethasone - pharmacology Emphysema Fibrosis Fibrosis - drug therapy Inflammation Inflammation - pathology Inflammatory diseases Leukocyte Count Leukocytes (eosinophilic) Linolenic acid Lung - pathology lung inflammation Lungs Male Medical treatment Monocytes Nitrogen dioxide Ovalbumin Ovalbumin - pharmacology ovalbumin‐sensitized rats Oxidative stress Rats Rats, Wistar Respiratory tract Respiratory tract diseases Rodents Superoxide Dismutase |
| title | Alpha‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats |
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