Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice

The study goal was to evaluate the transplacental transfer of two corticosteroids, budesonide (BUD) and fluticasone propionate (FP), in pregnant mice and investigate whether P-glycoprotein (P-gp) might be involved in reducing BUD transplacental transfer. Pregnant mice ( N = 18) received intravenous...

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Veröffentlicht in:	The AAPS journal 2019-07, Vol.21 (4), p.53-53, Article 53
Hauptverfasser:	Zaidi, Syedsaoud, Chen, Mong-Jen, Lee, Daniel T., Neubart, Elsa, Ewing, Pär, Miller-Larsson, Anna, Hochhaus, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Budesonide - administration & dosage Budesonide - blood Budesonide - pharmacokinetics Dose-Response Relationship, Drug Female Fetus - metabolism Fluticasone - administration & dosage Fluticasone - blood Fluticasone - pharmacokinetics Injections, Intravenous Maternal Exposure Mice, Inbred C57BL Organ Specificity Pharmacology/Toxicology Pharmacy Placenta - metabolism Pregnancy Research Article Substrate Specificity
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