Brucellosis in pregnancy: results of multicenter ID-IRI study
Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment resp...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2019-07, Vol.38 (7), p.1261-1268 |
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| creator | Inan, Asuman Erdem, Hakan Elaldi, Nazif Gulsun, Serda Karahocagil, Mustafa K. Pekok, Abdullah U. Ulug, Mehmet Tekin, Recep Bosilkovski, Mile Kaya, Safak Haykir-Solay, Asli Demirdal, Tuna Kaya, Selcuk Sunnetcioglu, Mahmut Sener, Alper Tosun, Selma Aydin, Emsal Ural, Serap Yamazhan, Tansu Muhcu, Murat Ayaslioglu, Ergin Bilgic-Atli, Seval Erbay, Ayse Ergen, Pinar Kadanali, Ayten Sahin, Suzan Sahin-Horasan, Elif Avci, Ali Cag, Yakup Beeching, Nicholas J. |
| description | Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (
p
= 0.019), nausea and/or vomiting (
p
|
| doi_str_mv | 10.1007/s10096-019-03540-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2210264314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2209791140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-fb66cd9fb629f26a439c6eb5ae1aa3148711ae0426e58e14a5a3205b62ca65083</originalsourceid><addsrcrecordid>eNp9kM9LwzAYhoMobk7_AQ9S8OIlmt9tBA86fxUGgug5ZNnX0dG1M2kP219vZqeCBy_5AnneNx8PQqeUXFJC0qsQT60woRoTLgXBmz00pIJLLHjK99GQaC6wThkfoKMQFiSGsjQ9RANOdKYFzYbo5s53DqqqCWVIyjpZeZjXtnbr68RD6Ko2JE2RLOOldFC34JP8HueveRLabrY-RgeFrQKc7OYIvT8-vI2f8eTlKR_fTrDjqWxxMVXKzXQcTBdMWcG1UzCVFqi1nIospdQCEUyBzIAKKy1nREbcWSVJxkfoou9d-eajg9CaZRm2a9sami4YxihhSsSqiJ7_QRdN5-u4XaSITjWlgkSK9ZTzTQgeCrPy5dL6taHEbOWaXq6Jcs2XXLOJobNddTddwuwn8m0zArwHQnyq5-B___6n9hNHCYOF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2209791140</pqid></control><display><type>article</type><title>Brucellosis in pregnancy: results of multicenter ID-IRI study</title><source>SpringerLink Journals</source><creator>Inan, Asuman ; Erdem, Hakan ; Elaldi, Nazif ; Gulsun, Serda ; Karahocagil, Mustafa K. ; Pekok, Abdullah U. ; Ulug, Mehmet ; Tekin, Recep ; Bosilkovski, Mile ; Kaya, Safak ; Haykir-Solay, Asli ; Demirdal, Tuna ; Kaya, Selcuk ; Sunnetcioglu, Mahmut ; Sener, Alper ; Tosun, Selma ; Aydin, Emsal ; Ural, Serap ; Yamazhan, Tansu ; Muhcu, Murat ; Ayaslioglu, Ergin ; Bilgic-Atli, Seval ; Erbay, Ayse ; Ergen, Pinar ; Kadanali, Ayten ; Sahin, Suzan ; Sahin-Horasan, Elif ; Avci, Ali ; Cag, Yakup ; Beeching, Nicholas J.</creator><creatorcontrib>Inan, Asuman ; Erdem, Hakan ; Elaldi, Nazif ; Gulsun, Serda ; Karahocagil, Mustafa K. ; Pekok, Abdullah U. ; Ulug, Mehmet ; Tekin, Recep ; Bosilkovski, Mile ; Kaya, Safak ; Haykir-Solay, Asli ; Demirdal, Tuna ; Kaya, Selcuk ; Sunnetcioglu, Mahmut ; Sener, Alper ; Tosun, Selma ; Aydin, Emsal ; Ural, Serap ; Yamazhan, Tansu ; Muhcu, Murat ; Ayaslioglu, Ergin ; Bilgic-Atli, Seval ; Erbay, Ayse ; Ergen, Pinar ; Kadanali, Ayten ; Sahin, Suzan ; Sahin-Horasan, Elif ; Avci, Ali ; Cag, Yakup ; Beeching, Nicholas J.</creatorcontrib><description>Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (
p
= 0.019), nausea and/or vomiting (
p
< 0.001), vaginal bleeding (
p
< 0.001), anemia (blood hemoglobin < 11 g/dL;
p
< 0.001), high level of serum aspartate aminotransferase (> 41 IU/L;
p
= 0.025), oligohydramnios on ultrasonography (
p
= 0.0002), history of taking medication other than
Brucella
treatment during pregnancy (
p
= 0.027), and
Brucella
bacteremia (
p
= 0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-019-03540-z</identifier><identifier>PMID: 30989418</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anemia ; Aspartate aminotransferase ; Bacteremia ; Biomedical and Life Sciences ; Biomedicine ; Bleeding ; Brucella ; Brucellosis ; Complications ; Epidemiology ; Fetuses ; Fever ; Health risk assessment ; Hemoglobin ; Internal Medicine ; Low birth weight ; Medical Microbiology ; Miscarriage ; Nausea ; Neonates ; Original Article ; Pregnancy ; Pregnancy complications ; Splenomegaly ; Ultrasound ; Vagina ; Vomiting ; Weight</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2019-07, Vol.38 (7), p.1261-1268</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-fb66cd9fb629f26a439c6eb5ae1aa3148711ae0426e58e14a5a3205b62ca65083</citedby><cites>FETCH-LOGICAL-c375t-fb66cd9fb629f26a439c6eb5ae1aa3148711ae0426e58e14a5a3205b62ca65083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-019-03540-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-019-03540-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30989418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inan, Asuman</creatorcontrib><creatorcontrib>Erdem, Hakan</creatorcontrib><creatorcontrib>Elaldi, Nazif</creatorcontrib><creatorcontrib>Gulsun, Serda</creatorcontrib><creatorcontrib>Karahocagil, Mustafa K.</creatorcontrib><creatorcontrib>Pekok, Abdullah U.</creatorcontrib><creatorcontrib>Ulug, Mehmet</creatorcontrib><creatorcontrib>Tekin, Recep</creatorcontrib><creatorcontrib>Bosilkovski, Mile</creatorcontrib><creatorcontrib>Kaya, Safak</creatorcontrib><creatorcontrib>Haykir-Solay, Asli</creatorcontrib><creatorcontrib>Demirdal, Tuna</creatorcontrib><creatorcontrib>Kaya, Selcuk</creatorcontrib><creatorcontrib>Sunnetcioglu, Mahmut</creatorcontrib><creatorcontrib>Sener, Alper</creatorcontrib><creatorcontrib>Tosun, Selma</creatorcontrib><creatorcontrib>Aydin, Emsal</creatorcontrib><creatorcontrib>Ural, Serap</creatorcontrib><creatorcontrib>Yamazhan, Tansu</creatorcontrib><creatorcontrib>Muhcu, Murat</creatorcontrib><creatorcontrib>Ayaslioglu, Ergin</creatorcontrib><creatorcontrib>Bilgic-Atli, Seval</creatorcontrib><creatorcontrib>Erbay, Ayse</creatorcontrib><creatorcontrib>Ergen, Pinar</creatorcontrib><creatorcontrib>Kadanali, Ayten</creatorcontrib><creatorcontrib>Sahin, Suzan</creatorcontrib><creatorcontrib>Sahin-Horasan, Elif</creatorcontrib><creatorcontrib>Avci, Ali</creatorcontrib><creatorcontrib>Cag, Yakup</creatorcontrib><creatorcontrib>Beeching, Nicholas J.</creatorcontrib><title>Brucellosis in pregnancy: results of multicenter ID-IRI study</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (
p
= 0.019), nausea and/or vomiting (
p
< 0.001), vaginal bleeding (
p
< 0.001), anemia (blood hemoglobin < 11 g/dL;
p
< 0.001), high level of serum aspartate aminotransferase (> 41 IU/L;
p
= 0.025), oligohydramnios on ultrasonography (
p
= 0.0002), history of taking medication other than
Brucella
treatment during pregnancy (
p
= 0.027), and
Brucella
bacteremia (
p
= 0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.</description><subject>Anemia</subject><subject>Aspartate aminotransferase</subject><subject>Bacteremia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bleeding</subject><subject>Brucella</subject><subject>Brucellosis</subject><subject>Complications</subject><subject>Epidemiology</subject><subject>Fetuses</subject><subject>Fever</subject><subject>Health risk assessment</subject><subject>Hemoglobin</subject><subject>Internal Medicine</subject><subject>Low birth weight</subject><subject>Medical Microbiology</subject><subject>Miscarriage</subject><subject>Nausea</subject><subject>Neonates</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Splenomegaly</subject><subject>Ultrasound</subject><subject>Vagina</subject><subject>Vomiting</subject><subject>Weight</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kM9LwzAYhoMobk7_AQ9S8OIlmt9tBA86fxUGgug5ZNnX0dG1M2kP219vZqeCBy_5AnneNx8PQqeUXFJC0qsQT60woRoTLgXBmz00pIJLLHjK99GQaC6wThkfoKMQFiSGsjQ9RANOdKYFzYbo5s53DqqqCWVIyjpZeZjXtnbr68RD6Ko2JE2RLOOldFC34JP8HueveRLabrY-RgeFrQKc7OYIvT8-vI2f8eTlKR_fTrDjqWxxMVXKzXQcTBdMWcG1UzCVFqi1nIospdQCEUyBzIAKKy1nREbcWSVJxkfoou9d-eajg9CaZRm2a9sami4YxihhSsSqiJ7_QRdN5-u4XaSITjWlgkSK9ZTzTQgeCrPy5dL6taHEbOWaXq6Jcs2XXLOJobNddTddwuwn8m0zArwHQnyq5-B___6n9hNHCYOF</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Inan, Asuman</creator><creator>Erdem, Hakan</creator><creator>Elaldi, Nazif</creator><creator>Gulsun, 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results of multicenter ID-IRI study</title><author>Inan, Asuman ; Erdem, Hakan ; Elaldi, Nazif ; Gulsun, Serda ; Karahocagil, Mustafa K. ; Pekok, Abdullah U. ; Ulug, Mehmet ; Tekin, Recep ; Bosilkovski, Mile ; Kaya, Safak ; Haykir-Solay, Asli ; Demirdal, Tuna ; Kaya, Selcuk ; Sunnetcioglu, Mahmut ; Sener, Alper ; Tosun, Selma ; Aydin, Emsal ; Ural, Serap ; Yamazhan, Tansu ; Muhcu, Murat ; Ayaslioglu, Ergin ; Bilgic-Atli, Seval ; Erbay, Ayse ; Ergen, Pinar ; Kadanali, Ayten ; Sahin, Suzan ; Sahin-Horasan, Elif ; Avci, Ali ; Cag, Yakup ; Beeching, Nicholas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-fb66cd9fb629f26a439c6eb5ae1aa3148711ae0426e58e14a5a3205b62ca65083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anemia</topic><topic>Aspartate aminotransferase</topic><topic>Bacteremia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bleeding</topic><topic>Brucella</topic><topic>Brucellosis</topic><topic>Complications</topic><topic>Epidemiology</topic><topic>Fetuses</topic><topic>Fever</topic><topic>Health risk assessment</topic><topic>Hemoglobin</topic><topic>Internal Medicine</topic><topic>Low birth weight</topic><topic>Medical Microbiology</topic><topic>Miscarriage</topic><topic>Nausea</topic><topic>Neonates</topic><topic>Original Article</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Splenomegaly</topic><topic>Ultrasound</topic><topic>Vagina</topic><topic>Vomiting</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inan, Asuman</creatorcontrib><creatorcontrib>Erdem, Hakan</creatorcontrib><creatorcontrib>Elaldi, Nazif</creatorcontrib><creatorcontrib>Gulsun, Serda</creatorcontrib><creatorcontrib>Karahocagil, Mustafa K.</creatorcontrib><creatorcontrib>Pekok, Abdullah 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inan, Asuman</au><au>Erdem, Hakan</au><au>Elaldi, Nazif</au><au>Gulsun, Serda</au><au>Karahocagil, Mustafa K.</au><au>Pekok, Abdullah U.</au><au>Ulug, Mehmet</au><au>Tekin, Recep</au><au>Bosilkovski, Mile</au><au>Kaya, Safak</au><au>Haykir-Solay, Asli</au><au>Demirdal, Tuna</au><au>Kaya, Selcuk</au><au>Sunnetcioglu, Mahmut</au><au>Sener, Alper</au><au>Tosun, Selma</au><au>Aydin, Emsal</au><au>Ural, Serap</au><au>Yamazhan, Tansu</au><au>Muhcu, Murat</au><au>Ayaslioglu, Ergin</au><au>Bilgic-Atli, Seval</au><au>Erbay, Ayse</au><au>Ergen, Pinar</au><au>Kadanali, Ayten</au><au>Sahin, Suzan</au><au>Sahin-Horasan, Elif</au><au>Avci, Ali</au><au>Cag, Yakup</au><au>Beeching, Nicholas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brucellosis in pregnancy: results of multicenter ID-IRI study</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>38</volume><issue>7</issue><spage>1261</spage><epage>1268</epage><pages>1261-1268</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (
p
= 0.019), nausea and/or vomiting (
p
< 0.001), vaginal bleeding (
p
< 0.001), anemia (blood hemoglobin < 11 g/dL;
p
< 0.001), high level of serum aspartate aminotransferase (> 41 IU/L;
p
= 0.025), oligohydramnios on ultrasonography (
p
= 0.0002), history of taking medication other than
Brucella
treatment during pregnancy (
p
= 0.027), and
Brucella
bacteremia (
p
= 0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30989418</pmid><doi>10.1007/s10096-019-03540-z</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2019-07, Vol.38 (7), p.1261-1268 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2210264314 |
| source | SpringerLink Journals |
| subjects | Anemia Aspartate aminotransferase Bacteremia Biomedical and Life Sciences Biomedicine Bleeding Brucella Brucellosis Complications Epidemiology Fetuses Fever Health risk assessment Hemoglobin Internal Medicine Low birth weight Medical Microbiology Miscarriage Nausea Neonates Original Article Pregnancy Pregnancy complications Splenomegaly Ultrasound Vagina Vomiting Weight |
| title | Brucellosis in pregnancy: results of multicenter ID-IRI study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A53%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brucellosis%20in%20pregnancy:%20results%20of%20multicenter%20ID-IRI%20study&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Inan,%20Asuman&rft.date=2019-07-01&rft.volume=38&rft.issue=7&rft.spage=1261&rft.epage=1268&rft.pages=1261-1268&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-019-03540-z&rft_dat=%3Cproquest_cross%3E2209791140%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2209791140&rft_id=info:pmid/30989418&rfr_iscdi=true |