Inhaled Corticosteroids for the Prevention of Bronchopulmonary Dysplasia and Complications of Prematurity
[...]this has been associated with increasing rates of bronchopulmonary dysplasia (BPD) and neurodevelopmental disabilities (2, 3). Because postnatal treatment with systemic corticosteroids has been shown to improve pulmonary outcomes but worsen neurodevelopmental outcomes (4), Bassler and colleague...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2019-07, Vol.200 (1), p.98-100 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Vazquez-Garcia, Gerardo A Fierro, Julie L Quinlan, Courtney M Tapia, Ignacio E |
| description | [...]this has been associated with increasing rates of bronchopulmonary dysplasia (BPD) and neurodevelopmental disabilities (2, 3). Because postnatal treatment with systemic corticosteroids has been shown to improve pulmonary outcomes but worsen neurodevelopmental outcomes (4), Bassler and colleagues tested inhaled budesonide as a preventive treatment for BPD and associated complications as part of the NEUROSIS (Neonatal European Study of Inhaled Steroids) trial group published in 2015 (5). Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Forty-one neonates from three medical centers with birth weight |
| doi_str_mv | 10.1164/rccm.201808-1469RR |
| format | Article |
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Because postnatal treatment with systemic corticosteroids has been shown to improve pulmonary outcomes but worsen neurodevelopmental outcomes (4), Bassler and colleagues tested inhaled budesonide as a preventive treatment for BPD and associated complications as part of the NEUROSIS (Neonatal European Study of Inhaled Steroids) trial group published in 2015 (5). Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Forty-one neonates from three medical centers with birth weight <1,250 g, gestational age <32 weeks, need for mechanical ventilation, FiO2 of greater than 0.30 but less than 0.60, postnatal age of 10 to 28 days, and 48 to 72 hours of stable ventilator requirements were included. 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Because postnatal treatment with systemic corticosteroids has been shown to improve pulmonary outcomes but worsen neurodevelopmental outcomes (4), Bassler and colleagues tested inhaled budesonide as a preventive treatment for BPD and associated complications as part of the NEUROSIS (Neonatal European Study of Inhaled Steroids) trial group published in 2015 (5). Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Forty-one neonates from three medical centers with birth weight <1,250 g, gestational age <32 weeks, need for mechanical ventilation, FiO2 of greater than 0.30 but less than 0.60, postnatal age of 10 to 28 days, and 48 to 72 hours of stable ventilator requirements were included. 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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adrenal Cortex Hormones Beclomethasone Bronchopulmonary Dysplasia Double-Blind Method Health risk assessment Humans Infant, Newborn Lung diseases Mortality Pilot Projects Respiratory therapy Trends |
| title | Inhaled Corticosteroids for the Prevention of Bronchopulmonary Dysplasia and Complications of Prematurity |
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