Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia
Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to...
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| Veröffentlicht in: | Dermatology online journal 2019-03, Vol.25 (3) |
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| creator | Borda, Luis J Mervis, Joshua S Kirsner, Robert S |
| description | Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in that it shares features of both localized and generalized forms. Moreover, the temporal and spatial association with pyoderma gangrenosum is unique and may reflect a related inflammatory pathway. |
| doi_str_mv | 10.5070/D3253043334 |
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We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in that it shares features of both localized and generalized forms. Moreover, the temporal and spatial association with pyoderma gangrenosum is unique and may reflect a related inflammatory pathway.</description><identifier>ISSN: 1087-2108</identifier><identifier>EISSN: 1087-2108</identifier><identifier>DOI: 10.5070/D3253043334</identifier><identifier>PMID: 30982302</identifier><language>eng</language><publisher>United States: University of California Digital Library - eScholarship</publisher><subject>Aged, 80 and over ; Amputation ; Amputation Stumps - pathology ; Granuloma Annulare - complications ; Granuloma Annulare - diagnosis ; Granuloma Annulare - pathology ; Granulomas ; Humans ; Leg Dermatoses - complications ; Leg Dermatoses - diagnosis ; Leg Dermatoses - pathology ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell - complications ; Male ; Metabolic disorders ; Pyoderma Gangrenosum - complications ; Pyoderma Gangrenosum - diagnosis ; Pyoderma Gangrenosum - surgery ; Skin diseases</subject><ispartof>Dermatology online journal, 2019-03, Vol.25 (3)</ispartof><rights>2019. 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We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in that it shares features of both localized and generalized forms. Moreover, the temporal and spatial association with pyoderma gangrenosum is unique and may reflect a related inflammatory pathway.</description><subject>Aged, 80 and over</subject><subject>Amputation</subject><subject>Amputation Stumps - pathology</subject><subject>Granuloma Annulare - complications</subject><subject>Granuloma Annulare - diagnosis</subject><subject>Granuloma Annulare - pathology</subject><subject>Granulomas</subject><subject>Humans</subject><subject>Leg Dermatoses - complications</subject><subject>Leg Dermatoses - diagnosis</subject><subject>Leg Dermatoses - pathology</subject><subject>Leukemia</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - complications</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Pyoderma Gangrenosum - complications</subject><subject>Pyoderma Gangrenosum - diagnosis</subject><subject>Pyoderma Gangrenosum - surgery</subject><subject>Skin diseases</subject><issn>1087-2108</issn><issn>1087-2108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpd0M9LwzAUB_AgipvTk3cpeBFk-pI0aXuU-RMGXty5vKXpltkmM2mR_fdmbMrw8vI9fPJ4fAm5pHAnIIP7R84Eh5Rznh6RIYU8G7M4jw_ygJyFsAJgkAp-SgYcipxxYEOymFnTYKc9NsnCo-0b12KCNgb0OjE2wRCcMtgZZ5Nv0y2T9cZV2ke1QLvw2rrQt_FHlaild9aopNm066VTm26bdf-pW4Pn5KTGJuiL_Tsis-enj8nrePr-8jZ5mI4Vk0U6nmuGkuZzqDCVokCkkmVaiFpJkELmoqor5Aw41rouFBWqyEURcZGlFKXiI3Kz27v27qvXoStbE5RuGrTa9aFksQ4AmUMR6fU_unK9t_G6qEROM2CURnW7U8q7ELyuy7U3LfpNSaHc9l8e9B_11X5nP2919Wd_C-c_JGyAYQ</recordid><startdate>20190315</startdate><enddate>20190315</enddate><creator>Borda, Luis J</creator><creator>Mervis, Joshua S</creator><creator>Kirsner, Robert S</creator><general>University of California Digital Library - eScholarship</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190315</creationdate><title>Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia</title><author>Borda, Luis J ; Mervis, Joshua S ; Kirsner, Robert S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2694-be2a618b0da4659aa1627e55fc6065685dfda3203afef9c15c9859da49741a6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged, 80 and over</topic><topic>Amputation</topic><topic>Amputation Stumps - pathology</topic><topic>Granuloma Annulare - complications</topic><topic>Granuloma Annulare - diagnosis</topic><topic>Granuloma Annulare - pathology</topic><topic>Granulomas</topic><topic>Humans</topic><topic>Leg Dermatoses - complications</topic><topic>Leg Dermatoses - diagnosis</topic><topic>Leg Dermatoses - pathology</topic><topic>Leukemia</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - complications</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Pyoderma Gangrenosum - complications</topic><topic>Pyoderma Gangrenosum - diagnosis</topic><topic>Pyoderma Gangrenosum - surgery</topic><topic>Skin diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borda, Luis J</creatorcontrib><creatorcontrib>Mervis, Joshua S</creatorcontrib><creatorcontrib>Kirsner, Robert S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology online journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borda, Luis J</au><au>Mervis, Joshua S</au><au>Kirsner, Robert S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia</atitle><jtitle>Dermatology online journal</jtitle><addtitle>Dermatol Online J</addtitle><date>2019-03-15</date><risdate>2019</risdate><volume>25</volume><issue>3</issue><issn>1087-2108</issn><eissn>1087-2108</eissn><abstract>Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in that it shares features of both localized and generalized forms. Moreover, the temporal and spatial association with pyoderma gangrenosum is unique and may reflect a related inflammatory pathway.</abstract><cop>United States</cop><pub>University of California Digital Library - eScholarship</pub><pmid>30982302</pmid><doi>10.5070/D3253043334</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged, 80 and over Amputation Amputation Stumps - pathology Granuloma Annulare - complications Granuloma Annulare - diagnosis Granuloma Annulare - pathology Granulomas Humans Leg Dermatoses - complications Leg Dermatoses - diagnosis Leg Dermatoses - pathology Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - complications Male Metabolic disorders Pyoderma Gangrenosum - complications Pyoderma Gangrenosum - diagnosis Pyoderma Gangrenosum - surgery Skin diseases |
| title | Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia |
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