Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience
Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology. We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized revie...
Gespeichert in:
| Veröffentlicht in: | The American journal of surgery 2020-04, Vol.219 (4), p.651-654 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 654 |
|---|---|
| container_issue | 4 |
| container_start_page | 651 |
| container_title | The American journal of surgery |
| container_volume | 219 |
| creator | Wiens, Naomi Hoffman, Daniel I. Huang, Cassie Ye Nayak, Anupma Tchou, Julia |
| description | Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology.
We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared.
Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1–138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME.
Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
•Unique organization of benign, atypical, malignant AME epidemiology/outcomes.•No local recurrences observed with negative margins in atypical, malignant AME.•Malignant AME carries metastatic potential and may require multimodal therapy.•AME rarity: within 18 years only 12 cases were found after centralized review.•Compares published AME manuscripts in a concise, easy to read table with discussion. |
| doi_str_mv | 10.1016/j.amjsurg.2019.03.026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2210002466</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002961019303630</els_id><sourcerecordid>2417039026</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-5ca9d18c44290069b188b79b4348b662e5635d4f6d17a6d02ece9aae5d86b3f13</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EokPhEUCWWNBFJ_gnceJuEBrxJ1ViA2vLsW-mjhI72A5iXoDnrqczsGDDyrL1nXOvz0HoJSUVJVS8HSs9j2mN-4oRKivCK8LEI7ShXSu3tOv4Y7QhhLCtFJRcoGcpjeVKac2fogtOZMealm_Q793kvDN6wuZOR20yRJeyMwlrb3FYswkzJBwG3IN3e3-NdT4sR8H1AzHrqbxqn3EfQaeMtQUf5kOAxeU7mFyY9Q3WODm_nwA7X8zzml3wbxKGX0sZB97Ac_Rk0FOCF-fzEn3_-OHb7vP29uunL7v3t1tTNzJvG6OlpZ2payYJEbIvH-1b2de87nohGDSCN7YehKWtFpYwMCC1hsZ2oucD5Zfo6uS7xPBjhZTV7JKBadIewpoUY_QYWi1EQV__g45hjb5sp1hNW8JlCbxQzYkyMaQUYVBLdLOOB0WJOhalRnUuSh2LUoSrk-7V2X3tZ7B_VX-aKcC7EwAljp8OokrmISrrIpisbHD_GXEPySmpGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2417039026</pqid></control><display><type>article</type><title>Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wiens, Naomi ; Hoffman, Daniel I. ; Huang, Cassie Ye ; Nayak, Anupma ; Tchou, Julia</creator><creatorcontrib>Wiens, Naomi ; Hoffman, Daniel I. ; Huang, Cassie Ye ; Nayak, Anupma ; Tchou, Julia</creatorcontrib><description>Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology.
We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared.
Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1–138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME.
Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
•Unique organization of benign, atypical, malignant AME epidemiology/outcomes.•No local recurrences observed with negative margins in atypical, malignant AME.•Malignant AME carries metastatic potential and may require multimodal therapy.•AME rarity: within 18 years only 12 cases were found after centralized review.•Compares published AME manuscripts in a concise, easy to read table with discussion.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2019.03.026</identifier><identifier>PMID: 30982573</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenomyoepithelioma ; Adenomyoepithelioma - pathology ; Adenomyoepithelioma - therapy ; Adult ; Aged ; Aged, 80 and over ; Asymmetry ; Atypical adenomyoepithelioma ; Benign ; Benign breast disease ; Biopsy ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cancer therapies ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - therapy ; Chemotherapy ; Clinical outcomes ; Demographics ; Demography ; Female ; Follow-Up Studies ; Histology ; Hormone replacement therapy ; Humans ; Lymphatic system ; Malignant adenomyoepithelioma ; Mammography ; Mastectomy ; Mastectomy, Segmental ; Metastases ; Metastasis ; Middle Aged ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - therapy ; Pathology ; Patients ; Radiotherapy, Adjuvant ; Studies ; Surgery ; Tumors ; Ultrasonic imaging</subject><ispartof>The American journal of surgery, 2020-04, Vol.219 (4), p.651-654</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-5ca9d18c44290069b188b79b4348b662e5635d4f6d17a6d02ece9aae5d86b3f13</citedby><cites>FETCH-LOGICAL-c459t-5ca9d18c44290069b188b79b4348b662e5635d4f6d17a6d02ece9aae5d86b3f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961019303630$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30982573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiens, Naomi</creatorcontrib><creatorcontrib>Hoffman, Daniel I.</creatorcontrib><creatorcontrib>Huang, Cassie Ye</creatorcontrib><creatorcontrib>Nayak, Anupma</creatorcontrib><creatorcontrib>Tchou, Julia</creatorcontrib><title>Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology.
We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared.
Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1–138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME.
Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
•Unique organization of benign, atypical, malignant AME epidemiology/outcomes.•No local recurrences observed with negative margins in atypical, malignant AME.•Malignant AME carries metastatic potential and may require multimodal therapy.•AME rarity: within 18 years only 12 cases were found after centralized review.•Compares published AME manuscripts in a concise, easy to read table with discussion.</description><subject>Adenomyoepithelioma</subject><subject>Adenomyoepithelioma - pathology</subject><subject>Adenomyoepithelioma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asymmetry</subject><subject>Atypical adenomyoepithelioma</subject><subject>Benign</subject><subject>Benign breast disease</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer therapies</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - therapy</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Demographics</subject><subject>Demography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Histology</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Malignant adenomyoepithelioma</subject><subject>Mammography</subject><subject>Mastectomy</subject><subject>Mastectomy, Segmental</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - therapy</subject><subject>Pathology</subject><subject>Patients</subject><subject>Radiotherapy, Adjuvant</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1u1DAUhS0EokPhEUCWWNBFJ_gnceJuEBrxJ1ViA2vLsW-mjhI72A5iXoDnrqczsGDDyrL1nXOvz0HoJSUVJVS8HSs9j2mN-4oRKivCK8LEI7ShXSu3tOv4Y7QhhLCtFJRcoGcpjeVKac2fogtOZMealm_Q793kvDN6wuZOR20yRJeyMwlrb3FYswkzJBwG3IN3e3-NdT4sR8H1AzHrqbxqn3EfQaeMtQUf5kOAxeU7mFyY9Q3WODm_nwA7X8zzml3wbxKGX0sZB97Ac_Rk0FOCF-fzEn3_-OHb7vP29uunL7v3t1tTNzJvG6OlpZ2payYJEbIvH-1b2de87nohGDSCN7YehKWtFpYwMCC1hsZ2oucD5Zfo6uS7xPBjhZTV7JKBadIewpoUY_QYWi1EQV__g45hjb5sp1hNW8JlCbxQzYkyMaQUYVBLdLOOB0WJOhalRnUuSh2LUoSrk-7V2X3tZ7B_VX-aKcC7EwAljp8OokrmISrrIpisbHD_GXEPySmpGQ</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Wiens, Naomi</creator><creator>Hoffman, Daniel I.</creator><creator>Huang, Cassie Ye</creator><creator>Nayak, Anupma</creator><creator>Tchou, Julia</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience</title><author>Wiens, Naomi ; Hoffman, Daniel I. ; Huang, Cassie Ye ; Nayak, Anupma ; Tchou, Julia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-5ca9d18c44290069b188b79b4348b662e5635d4f6d17a6d02ece9aae5d86b3f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenomyoepithelioma</topic><topic>Adenomyoepithelioma - pathology</topic><topic>Adenomyoepithelioma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asymmetry</topic><topic>Atypical adenomyoepithelioma</topic><topic>Benign</topic><topic>Benign breast disease</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer therapies</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - therapy</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Demographics</topic><topic>Demography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Histology</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Malignant adenomyoepithelioma</topic><topic>Mammography</topic><topic>Mastectomy</topic><topic>Mastectomy, Segmental</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - therapy</topic><topic>Pathology</topic><topic>Patients</topic><topic>Radiotherapy, Adjuvant</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiens, Naomi</creatorcontrib><creatorcontrib>Hoffman, Daniel I.</creatorcontrib><creatorcontrib>Huang, Cassie Ye</creatorcontrib><creatorcontrib>Nayak, Anupma</creatorcontrib><creatorcontrib>Tchou, Julia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiens, Naomi</au><au>Hoffman, Daniel I.</au><au>Huang, Cassie Ye</au><au>Nayak, Anupma</au><au>Tchou, Julia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2020-04</date><risdate>2020</risdate><volume>219</volume><issue>4</issue><spage>651</spage><epage>654</epage><pages>651-654</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology.
We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared.
Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1–138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME.
Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
•Unique organization of benign, atypical, malignant AME epidemiology/outcomes.•No local recurrences observed with negative margins in atypical, malignant AME.•Malignant AME carries metastatic potential and may require multimodal therapy.•AME rarity: within 18 years only 12 cases were found after centralized review.•Compares published AME manuscripts in a concise, easy to read table with discussion.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30982573</pmid><doi>10.1016/j.amjsurg.2019.03.026</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 2020-04, Vol.219 (4), p.651-654 |
| issn | 0002-9610 1879-1883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2210002466 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenomyoepithelioma Adenomyoepithelioma - pathology Adenomyoepithelioma - therapy Adult Aged Aged, 80 and over Asymmetry Atypical adenomyoepithelioma Benign Benign breast disease Biopsy Breast cancer Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer therapies Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - therapy Chemotherapy Clinical outcomes Demographics Demography Female Follow-Up Studies Histology Hormone replacement therapy Humans Lymphatic system Malignant adenomyoepithelioma Mammography Mastectomy Mastectomy, Segmental Metastases Metastasis Middle Aged Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - therapy Pathology Patients Radiotherapy, Adjuvant Studies Surgery Tumors Ultrasonic imaging |
| title | Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T09%3A26%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20characteristics%20and%20outcomes%20of%20benign,%20atypical,%20and%20malignant%20breast%20adenomyoepithelioma:%20a%20single%20institution's%20experience&rft.jtitle=The%20American%20journal%20of%20surgery&rft.au=Wiens,%20Naomi&rft.date=2020-04&rft.volume=219&rft.issue=4&rft.spage=651&rft.epage=654&rft.pages=651-654&rft.issn=0002-9610&rft.eissn=1879-1883&rft_id=info:doi/10.1016/j.amjsurg.2019.03.026&rft_dat=%3Cproquest_cross%3E2417039026%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2417039026&rft_id=info:pmid/30982573&rft_els_id=S0002961019303630&rfr_iscdi=true |