Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes
The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with inte...
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| Veröffentlicht in: | Biomedical Research 2019/04/01, Vol.40(2), pp.79-85 |
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| creator | IWANAGA, Toshihiko NIO-KOBAYASHI, Junko TAKAHASHI-IWANAGA, Hiromi |
| description | The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages. |
| doi_str_mv | 10.2220/biomedres.40.79 |
| format | Article |
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Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages.</description><identifier>ISSN: 0388-6107</identifier><identifier>EISSN: 1880-313X</identifier><identifier>DOI: 10.2220/biomedres.40.79</identifier><identifier>PMID: 30982803</identifier><language>eng</language><publisher>Japan: Biomedical Research Press</publisher><subject>Animals ; Animals, Newborn ; Antibodies ; Basement Membrane - metabolism ; Basement Membrane - ultrastructure ; Blood vessels ; Blood Vessels - anatomy & histology ; Blood Vessels - ultrastructure ; Bushes ; Collagen ; Cytoskeleton - metabolism ; Cytoskeleton - ultrastructure ; Embryo, Mammalian ; Extracellular matrix ; Extracellular Matrix - metabolism ; Extracellular Matrix - ultrastructure ; Female ; Fibers ; Fibrils ; Filaments ; Gene Expression ; Immunohistochemistry ; Integrin beta1 - genetics ; Integrin beta1 - metabolism ; Integrin beta1 - ultrastructure ; Macrophages ; Macrophages - metabolism ; Macrophages - ultrastructure ; Mice ; Microscopy, Electron ; Neovascularization, Physiologic ; Pregnancy ; Rodents ; Vascular system ; Vitreous Body - anatomy & histology ; Vitreous Body - blood supply ; Vitreous Body - ultrastructure</subject><ispartof>Biomedical Research, 2019/04/01, Vol.40(2), pp.79-85</ispartof><rights>2019 Biomedical Research Press</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c469t-e07d8ad13bcd5913076d94c7c088314fe55264e0d0b8f119dd49f397f617f8053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30982803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IWANAGA, Toshihiko</creatorcontrib><creatorcontrib>NIO-KOBAYASHI, Junko</creatorcontrib><creatorcontrib>TAKAHASHI-IWANAGA, Hiromi</creatorcontrib><title>Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes</title><title>Biomedical Research</title><addtitle>Biomed. Res.</addtitle><description>The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies</subject><subject>Basement Membrane - metabolism</subject><subject>Basement Membrane - ultrastructure</subject><subject>Blood vessels</subject><subject>Blood Vessels - anatomy & histology</subject><subject>Blood Vessels - ultrastructure</subject><subject>Bushes</subject><subject>Collagen</subject><subject>Cytoskeleton - metabolism</subject><subject>Cytoskeleton - ultrastructure</subject><subject>Embryo, Mammalian</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Extracellular Matrix - ultrastructure</subject><subject>Female</subject><subject>Fibers</subject><subject>Fibrils</subject><subject>Filaments</subject><subject>Gene Expression</subject><subject>Immunohistochemistry</subject><subject>Integrin beta1 - genetics</subject><subject>Integrin beta1 - metabolism</subject><subject>Integrin beta1 - ultrastructure</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - ultrastructure</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>Neovascularization, Physiologic</subject><subject>Pregnancy</subject><subject>Rodents</subject><subject>Vascular system</subject><subject>Vitreous Body - anatomy & histology</subject><subject>Vitreous Body - blood supply</subject><subject>Vitreous Body - ultrastructure</subject><issn>0388-6107</issn><issn>1880-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0E1LJDEQBuCwrKyzumdvEtiLlx4rnXQnOaq4HyB42QVvIZNUOxn7Q5O0Mv_eyLgD6ymEet6Xogg5YbCs6xrOV2Ea0EdMSwFLqT-RBVMKKs743WeyAK5U1TKQh-RrShsof6b4F3LIQataAV8QczmnddWHB6RhzHgfw0i70NsBx0xHzC9TfEjUpjS5YDN6-hLymq63tp-Cp882ubm3eY5vcTrMJY4lNo3FUtxiOiYHne0Tfnt_j8jfH9d_rn5VN7c_f19d3FROtDpXCNIr6xlfOd9oxkG2XgsnHSjFmeiwaepWIHhYqY4x7b3QHdeya5nsFDT8iJzteh_j9DRjymYIyWHf27LNnExdMwBgqlWFfv9AN9Mcx7JdUYJxKRsBRZ3vlItTShE78xjDYOPWMDBvtzf72xsBRuqSOH3vnVdlsPf_jl3A5Q5sUrb3uAc25uB6_L-w3rXuh25to8GRvwIjtpsX</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>IWANAGA, Toshihiko</creator><creator>NIO-KOBAYASHI, Junko</creator><creator>TAKAHASHI-IWANAGA, Hiromi</creator><general>Biomedical Research Press</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes</title><author>IWANAGA, Toshihiko ; NIO-KOBAYASHI, Junko ; TAKAHASHI-IWANAGA, Hiromi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-e07d8ad13bcd5913076d94c7c088314fe55264e0d0b8f119dd49f397f617f8053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies</topic><topic>Basement Membrane - metabolism</topic><topic>Basement Membrane - ultrastructure</topic><topic>Blood vessels</topic><topic>Blood Vessels - anatomy & histology</topic><topic>Blood Vessels - ultrastructure</topic><topic>Bushes</topic><topic>Collagen</topic><topic>Cytoskeleton - metabolism</topic><topic>Cytoskeleton - ultrastructure</topic><topic>Embryo, Mammalian</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - metabolism</topic><topic>Extracellular Matrix - ultrastructure</topic><topic>Female</topic><topic>Fibers</topic><topic>Fibrils</topic><topic>Filaments</topic><topic>Gene Expression</topic><topic>Immunohistochemistry</topic><topic>Integrin beta1 - genetics</topic><topic>Integrin beta1 - metabolism</topic><topic>Integrin beta1 - ultrastructure</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - ultrastructure</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>Neovascularization, Physiologic</topic><topic>Pregnancy</topic><topic>Rodents</topic><topic>Vascular system</topic><topic>Vitreous Body - anatomy & histology</topic><topic>Vitreous Body - blood supply</topic><topic>Vitreous Body - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IWANAGA, Toshihiko</creatorcontrib><creatorcontrib>NIO-KOBAYASHI, Junko</creatorcontrib><creatorcontrib>TAKAHASHI-IWANAGA, Hiromi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IWANAGA, Toshihiko</au><au>NIO-KOBAYASHI, Junko</au><au>TAKAHASHI-IWANAGA, Hiromi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes</atitle><jtitle>Biomedical Research</jtitle><addtitle>Biomed. Res.</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>40</volume><issue>2</issue><spage>79</spage><epage>85</epage><pages>79-85</pages><issn>0388-6107</issn><eissn>1880-313X</eissn><abstract>The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages.</abstract><cop>Japan</cop><pub>Biomedical Research Press</pub><pmid>30982803</pmid><doi>10.2220/biomedres.40.79</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Animals, Newborn Antibodies Basement Membrane - metabolism Basement Membrane - ultrastructure Blood vessels Blood Vessels - anatomy & histology Blood Vessels - ultrastructure Bushes Collagen Cytoskeleton - metabolism Cytoskeleton - ultrastructure Embryo, Mammalian Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Female Fibers Fibrils Filaments Gene Expression Immunohistochemistry Integrin beta1 - genetics Integrin beta1 - metabolism Integrin beta1 - ultrastructure Macrophages Macrophages - metabolism Macrophages - ultrastructure Mice Microscopy, Electron Neovascularization, Physiologic Pregnancy Rodents Vascular system Vitreous Body - anatomy & histology Vitreous Body - blood supply Vitreous Body - ultrastructure |
| title | Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes |
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