NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection

Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-06, Vol.513 (3), p.675-680
Hauptverfasser:	Zhang, Tingjuan, Du, Huihui, Feng, Siwei, Wu, Rui, Chen, Tingting, Jiang, Jiali, Peng, Yuanyi, Ye, Chao, Fang, Rendong
Format:	Artikel
Sprache:	eng
Schlagworte:	IL-1β Neutrophils NLPR3 inflammasome Serine proteases
Online-Zugang:	Volltext
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