Sulfate conjugates are the major metabolites in rats administrated with sesamin

Sesamin is known to have various biological effects. Although several metabolites of sesamin have been identified, its metabolism by phase II enzymes remains unclear, because usually its sulfo- and glucurono-conjugates in plasma and urine are analyzed after sulfatase/β-glucuronidase treatment. In th...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2019-04, Vol.34 (2), p.134-140
Hauptverfasser:	Yasuda, Kaori, Okamoto, Kairi, Ueno, Sera, Itoh, Kasumi, Nishikawa, Miyu, Ikushiro, Shinichi, Sakaki, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arylsulfotransferase - metabolism Cytosol - metabolism Dioxoles - administration & dosage Dioxoles - blood Dioxoles - metabolism Humans Lignan Lignans - administration & dosage Lignans - blood Lignans - metabolism Liver - metabolism Male Metabolites Rats Rats, Sprague-Dawley Sesamin Sulfate conjugate Sulfates - blood Sulfates - metabolism Sulfotransferase (SULT)
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