Plasma Steroid Profiles in Subclinical Compared With Overt Adrenal Cushing Syndrome

Abstract Context Diagnosis of subclinical adrenal hypercortisolism is based on several tests of the hypothalamic-pituitary-adrenal axis to establish mild alterations of cortisol secretion and dysregulated cortisol physiology. Objective We assessed whether plasma steroid profiles might assist diagnos...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2019-10, Vol.104 (10), p.4331-4340
Hauptverfasser:	Masjkur, Jimmy, Gruber, Matthias, Peitzsch, Mirko, Kaden, Denise, Di Dalmazi, Guido, Bidlingmaier, Martin, Zopp, Stephanie, Langton, Katharina, Fazel, Julia, Beuschlein, Felix, Bornstein, Stefan Richard, Reincke, Martin, Eisenhofer, Graeme
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenocorticotropic hormone Adrenocorticotropic Hormone - blood Chromatography, Liquid - methods Comparative analysis Corticosteroids Cross-Sectional Studies Cushing syndrome Cushing Syndrome - blood Cushing Syndrome - diagnosis Dehydroepiandrosterone Dexamethasone Diagnosis Ethylenediaminetetraacetic acid Female Germany Hormones Hospitals, University Humans Hydrocortisone Hydroxyprogesterone Hypertension Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiopathology Hypothalamus Male Mass spectrometry Mass spectroscopy Multivariate Analysis Nervous system diseases Pituitary Pregnenolone Progesterone Reference Values Retrospective Studies ROC Curve Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Steroid hormones Steroids Steroids - blood Sulfates Switzerland Tandem Mass Spectrometry - methods
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