Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony
We evaluated the effect of cardiac resynchronization therapy (CRT) on septal perfusion and thickening at 6 months post implantation assessed on Tc99m-MIBI Gated myocardial perfusion SPECT (GMPS).We also studied the association of change in septal perfusion and thickening with primary outcome defined...
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| Veröffentlicht in: | Journal of nuclear cardiology 2020-08, Vol.27 (4), p.1274-1284 |
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| creator | Patel, C. Kalaivani, M. Karthikeyan, G. Peix, A. Kumar, A. Massardo, T. Jiménez-Heffernan, A. Mesquita, C.T. Pabon, M. Butt, S. Alexanderson, E. Marin, V. Morozova, O. Paez, D. Garcia, E.V. |
| description | We evaluated the effect of cardiac resynchronization therapy (CRT) on septal perfusion and thickening at 6 months post implantation assessed on Tc99m-MIBI Gated myocardial perfusion SPECT (GMPS).We also studied the association of change in septal perfusion and thickening with primary outcome defined as at least one [improvement in ≥1NYHA class, left ventricular ejection fraction (LVEF) by ≥ 5%, reduction of end-systolic volume (ESV) by ≥ 15%, and improvement ≥ 5 points in Minnesota living with heart failure questionnaire (MLHFQ)].
One hundred and five patients underwent clinical and GMPS evaluation before and at 6 months post CRT.
Post CRT there was significant improvement in mean normalized septal perfusion uptake and in septal thickening (P value = 0.001, both). There was no significant relation between improvement in septal perfusion and primary outcome. However, improvement in septal thickening was statistically significant with favorable primary outcome (P = 0.001).There was no significant correlation between improvement of septal perfusion and improvement in LVEF, reduction in End diastolic volume (EDV), ESV, and Left ventricular Dyssynchrony (LVD). But, there was significant correlation between improvement of septal thickening and these parameters.
Improvement in septal thickening was associated with reverse remodeling, improvement in LVEF, and reduction of LVD. |
| doi_str_mv | 10.1007/s12350-019-01704-0 |
| format | Article |
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One hundred and five patients underwent clinical and GMPS evaluation before and at 6 months post CRT.
Post CRT there was significant improvement in mean normalized septal perfusion uptake and in septal thickening (P value = 0.001, both). There was no significant relation between improvement in septal perfusion and primary outcome. However, improvement in septal thickening was statistically significant with favorable primary outcome (P = 0.001).There was no significant correlation between improvement of septal perfusion and improvement in LVEF, reduction in End diastolic volume (EDV), ESV, and Left ventricular Dyssynchrony (LVD). But, there was significant correlation between improvement of septal thickening and these parameters.
Improvement in septal thickening was associated with reverse remodeling, improvement in LVEF, and reduction of LVD.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-019-01704-0</identifier><identifier>PMID: 30977094</identifier><language>eng</language><publisher>Cham: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Beta blockers ; Cardiac Resynchronization Therapy ; Cardiology ; dyssynchrony ; Ejection fraction ; Female ; Heart failure ; Heart Septum - pathology ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial Perfusion Imaging ; Nuclear Medicine ; Original Article ; Prospective Studies ; Radiology ; SPECT ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon ; Ventricular Function, Left - physiology ; Young Adult</subject><ispartof>Journal of nuclear cardiology, 2020-08, Vol.27 (4), p.1274-1284</ispartof><rights>2020 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2019</rights><rights>Journal of Nuclear Cardiology is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>American Society of Nuclear Cardiology 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-98583221c5b400d03cefec21f782bfc6daaaa09582bfb6eda9dd4fb500d072d53</citedby><cites>FETCH-LOGICAL-c456t-98583221c5b400d03cefec21f782bfc6daaaa09582bfb6eda9dd4fb500d072d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-019-01704-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-019-01704-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30977094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, C.</creatorcontrib><creatorcontrib>Kalaivani, M.</creatorcontrib><creatorcontrib>Karthikeyan, G.</creatorcontrib><creatorcontrib>Peix, A.</creatorcontrib><creatorcontrib>Kumar, A.</creatorcontrib><creatorcontrib>Massardo, T.</creatorcontrib><creatorcontrib>Jiménez-Heffernan, A.</creatorcontrib><creatorcontrib>Mesquita, C.T.</creatorcontrib><creatorcontrib>Pabon, M.</creatorcontrib><creatorcontrib>Butt, S.</creatorcontrib><creatorcontrib>Alexanderson, E.</creatorcontrib><creatorcontrib>Marin, V.</creatorcontrib><creatorcontrib>Morozova, O.</creatorcontrib><creatorcontrib>Paez, D.</creatorcontrib><creatorcontrib>Garcia, E.V.</creatorcontrib><title>Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>We evaluated the effect of cardiac resynchronization therapy (CRT) on septal perfusion and thickening at 6 months post implantation assessed on Tc99m-MIBI Gated myocardial perfusion SPECT (GMPS).We also studied the association of change in septal perfusion and thickening with primary outcome defined as at least one [improvement in ≥1NYHA class, left ventricular ejection fraction (LVEF) by ≥ 5%, reduction of end-systolic volume (ESV) by ≥ 15%, and improvement ≥ 5 points in Minnesota living with heart failure questionnaire (MLHFQ)].
One hundred and five patients underwent clinical and GMPS evaluation before and at 6 months post CRT.
Post CRT there was significant improvement in mean normalized septal perfusion uptake and in septal thickening (P value = 0.001, both). There was no significant relation between improvement in septal perfusion and primary outcome. However, improvement in septal thickening was statistically significant with favorable primary outcome (P = 0.001).There was no significant correlation between improvement of septal perfusion and improvement in LVEF, reduction in End diastolic volume (EDV), ESV, and Left ventricular Dyssynchrony (LVD). But, there was significant correlation between improvement of septal thickening and these parameters.
Improvement in septal thickening was associated with reverse remodeling, improvement in LVEF, and reduction of LVD.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Beta blockers</subject><subject>Cardiac Resynchronization Therapy</subject><subject>Cardiology</subject><subject>dyssynchrony</subject><subject>Ejection fraction</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Septum - pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>SPECT</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Ventricular Function, Left - physiology</subject><subject>Young Adult</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAQjRCIlsIf4IAiceFAYGzHSYy4VFX5kCpxgbPl2OOuS9ZZbGdR-EP9m3WaLkgc1pLlsee9N2M_F8VLAu8IQPs-Eso4VEBEni3UFTwqTglntGo4J49zDC2pGO_ISfEsxhsAEEyIp8UJA9G2IOrT4vbSWtSpHG2pVTBO6TJgnL3ehNG7Pyq50Zdpg0Ht5jKHEXdJDeUOg53iklPeHA7Txumf6J2__lCexzhqt9J_u7QpB7Sp3KNPwelpUKG0k9dL-m0uuMcQMa_b0eAwZIF7WTPHQyfz8-KJVUPEFw_rWfHj0-X3iy_V1bfPXy_Orypd8yZVouMdo5Ro3tcABpjGfD1KbNvR3urGqDxA8GXXN2iUMKa2PV-wLTWcnRVvVt1dGH9NGJPcuqhzU8rjOEVJKYgGOOFthr7-D3ozTsHn7iStGeW06aA-iqLQNrxmzYKiK0qHMcaAVu6C26owSwJyMVuuZststrw3W0ImvXqQnvotmr-Ug7sZwFZAzCl_jeFf7aOyH1cW5nfeu8yK2qHXaFzIX0Wa0R2j3wF4Q8xQ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Patel, C.</creator><creator>Kalaivani, M.</creator><creator>Karthikeyan, G.</creator><creator>Peix, A.</creator><creator>Kumar, A.</creator><creator>Massardo, T.</creator><creator>Jiménez-Heffernan, A.</creator><creator>Mesquita, C.T.</creator><creator>Pabon, M.</creator><creator>Butt, S.</creator><creator>Alexanderson, E.</creator><creator>Marin, V.</creator><creator>Morozova, O.</creator><creator>Paez, D.</creator><creator>Garcia, E.V.</creator><general>Elsevier Inc</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony</title><author>Patel, C. ; Kalaivani, M. ; Karthikeyan, G. ; Peix, A. ; Kumar, A. ; Massardo, T. ; Jiménez-Heffernan, A. ; Mesquita, C.T. ; Pabon, M. ; Butt, S. ; Alexanderson, E. ; Marin, V. ; Morozova, O. ; Paez, D. ; Garcia, E.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-98583221c5b400d03cefec21f782bfc6daaaa09582bfb6eda9dd4fb500d072d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Beta blockers</topic><topic>Cardiac Resynchronization Therapy</topic><topic>Cardiology</topic><topic>dyssynchrony</topic><topic>Ejection fraction</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Septum - pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>SPECT</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Ventricular Function, Left - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, C.</creatorcontrib><creatorcontrib>Kalaivani, M.</creatorcontrib><creatorcontrib>Karthikeyan, G.</creatorcontrib><creatorcontrib>Peix, A.</creatorcontrib><creatorcontrib>Kumar, A.</creatorcontrib><creatorcontrib>Massardo, T.</creatorcontrib><creatorcontrib>Jiménez-Heffernan, A.</creatorcontrib><creatorcontrib>Mesquita, C.T.</creatorcontrib><creatorcontrib>Pabon, M.</creatorcontrib><creatorcontrib>Butt, S.</creatorcontrib><creatorcontrib>Alexanderson, E.</creatorcontrib><creatorcontrib>Marin, V.</creatorcontrib><creatorcontrib>Morozova, O.</creatorcontrib><creatorcontrib>Paez, D.</creatorcontrib><creatorcontrib>Garcia, E.V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, C.</au><au>Kalaivani, M.</au><au>Karthikeyan, G.</au><au>Peix, A.</au><au>Kumar, A.</au><au>Massardo, T.</au><au>Jiménez-Heffernan, A.</au><au>Mesquita, C.T.</au><au>Pabon, M.</au><au>Butt, S.</au><au>Alexanderson, E.</au><au>Marin, V.</au><au>Morozova, O.</au><au>Paez, D.</au><au>Garcia, E.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>27</volume><issue>4</issue><spage>1274</spage><epage>1284</epage><pages>1274-1284</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>We evaluated the effect of cardiac resynchronization therapy (CRT) on septal perfusion and thickening at 6 months post implantation assessed on Tc99m-MIBI Gated myocardial perfusion SPECT (GMPS).We also studied the association of change in septal perfusion and thickening with primary outcome defined as at least one [improvement in ≥1NYHA class, left ventricular ejection fraction (LVEF) by ≥ 5%, reduction of end-systolic volume (ESV) by ≥ 15%, and improvement ≥ 5 points in Minnesota living with heart failure questionnaire (MLHFQ)].
One hundred and five patients underwent clinical and GMPS evaluation before and at 6 months post CRT.
Post CRT there was significant improvement in mean normalized septal perfusion uptake and in septal thickening (P value = 0.001, both). There was no significant relation between improvement in septal perfusion and primary outcome. However, improvement in septal thickening was statistically significant with favorable primary outcome (P = 0.001).There was no significant correlation between improvement of septal perfusion and improvement in LVEF, reduction in End diastolic volume (EDV), ESV, and Left ventricular Dyssynchrony (LVD). But, there was significant correlation between improvement of septal thickening and these parameters.
Improvement in septal thickening was associated with reverse remodeling, improvement in LVEF, and reduction of LVD.</abstract><cop>Cham</cop><pub>Elsevier Inc</pub><pmid>30977094</pmid><doi>10.1007/s12350-019-01704-0</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Beta blockers Cardiac Resynchronization Therapy Cardiology dyssynchrony Ejection fraction Female Heart failure Heart Septum - pathology Humans Imaging Male Medicine Medicine & Public Health Middle Aged Myocardial Perfusion Imaging Nuclear Medicine Original Article Prospective Studies Radiology SPECT Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon Ventricular Function, Left - physiology Young Adult |
| title | Effect of cardiac resynchronization therapy on septal perfusion and septal thickening: Association with left ventricular function, reverse remodelling and dyssynchrony |
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