Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs

A new fluconazole-functionalized polyoxometalate-based metal–organic framework (POMOF) [Ag3(FKZ)2(H2O)2][H3SiW12O40] (AgFKZSiW12) was successfully constructed, and its polypyrrole (PPy) coated composite AgFKZSiW12@PPy was also obtained via a facile ‘in situ’ oxidation polymerization process. The per...

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Veröffentlicht in:	Analyst (London) 2019-05, Vol.144 (10), p.3347-3356
Hauptverfasser:	Li, Xiao, Sun, Longjiang, Yang, Xiya, Zhou, Kunfeng, Zhang, Gongguo, Tong, Zhibo, Wang, Cheng, Sha, Jingquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic acid Biosensors Colorimetry Hydrogen peroxide Metal-organic frameworks Oxidation Peroxidase Polypyrroles Response time Synergistic effect Vitamin C
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creator	Li, Xiao Sun, Longjiang Yang, Xiya Zhou, Kunfeng Zhang, Gongguo Tong, Zhibo Wang, Cheng Sha, Jingquan
description	A new fluconazole-functionalized polyoxometalate-based metal–organic framework (POMOF) [Ag3(FKZ)2(H2O)2][H3SiW12O40] (AgFKZSiW12) was successfully constructed, and its polypyrrole (PPy) coated composite AgFKZSiW12@PPy was also obtained via a facile ‘in situ’ oxidation polymerization process. The peroxidase-like activity evaluation indicates that the maximized synergistic effect from the integration of PPy, SiW12 clusters, HFKZ drug molecules, and Ag ions deeply enhanced the overall performance. More importantly, AgFKZSiW12@PPy exhibits the fastest response time (30 s) among all the reported peroxidase mimics to date, including the pristine AgFKZSiW12 (2 min). Moreover, the AgFKZSiW12@PPy-based colorimetric biosensing platform towards H2O2 and ascorbic acid (AA) exhibits limits of detection (LOD) as low as 0.12 μM and 2.7 μM, respectively. This work reveals a promising prospect in medical diagnosis and biotechnology for colorimetric biosensor fabrication with high performance through the introduction of PPy.
doi_str_mv	10.1039/c9an00163h
format	Article
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The peroxidase-like activity evaluation indicates that the maximized synergistic effect from the integration of PPy, SiW12 clusters, HFKZ drug molecules, and Ag ions deeply enhanced the overall performance. More importantly, AgFKZSiW12@PPy exhibits the fastest response time (30 s) among all the reported peroxidase mimics to date, including the pristine AgFKZSiW12 (2 min). Moreover, the AgFKZSiW12@PPy-based colorimetric biosensing platform towards H2O2 and ascorbic acid (AA) exhibits limits of detection (LOD) as low as 0.12 μM and 2.7 μM, respectively. This work reveals a promising prospect in medical diagnosis and biotechnology for colorimetric biosensor fabrication with high performance through the introduction of PPy.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c9an00163h</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Ascorbic acid ; Biosensors ; Colorimetry ; Hydrogen peroxide ; Metal-organic frameworks ; Oxidation ; Peroxidase ; Polypyrroles ; Response time ; Synergistic effect ; Vitamin C</subject><ispartof>Analyst (London), 2019-05, Vol.144 (10), p.3347-3356</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Sun, Longjiang</creatorcontrib><creatorcontrib>Yang, Xiya</creatorcontrib><creatorcontrib>Zhou, Kunfeng</creatorcontrib><creatorcontrib>Zhang, Gongguo</creatorcontrib><creatorcontrib>Tong, Zhibo</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Sha, Jingquan</creatorcontrib><title>Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs</title><title>Analyst (London)</title><description>A new fluconazole-functionalized polyoxometalate-based metal–organic framework (POMOF) [Ag3(FKZ)2(H2O)2][H3SiW12O40] (AgFKZSiW12) was successfully constructed, and its polypyrrole (PPy) coated composite AgFKZSiW12@PPy was also obtained via a facile ‘in situ’ oxidation polymerization process. The peroxidase-like activity evaluation indicates that the maximized synergistic effect from the integration of PPy, SiW12 clusters, HFKZ drug molecules, and Ag ions deeply enhanced the overall performance. More importantly, AgFKZSiW12@PPy exhibits the fastest response time (30 s) among all the reported peroxidase mimics to date, including the pristine AgFKZSiW12 (2 min). Moreover, the AgFKZSiW12@PPy-based colorimetric biosensing platform towards H2O2 and ascorbic acid (AA) exhibits limits of detection (LOD) as low as 0.12 μM and 2.7 μM, respectively. 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source	Royal Society Of Chemistry Journals; Royal Society of Chemistry Journals Archive (1841-2007); Alma/SFX Local Collection
subjects	Ascorbic acid Biosensors Colorimetry Hydrogen peroxide Metal-organic frameworks Oxidation Peroxidase Polypyrroles Response time Synergistic effect Vitamin C
title	Enhancing the colorimetric detection of H2O2 and ascorbic acid on polypyrrole coated fluconazole-functionalized POMOFs
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