Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients
Purpose The currently used system to classify the lower limb alignment (neutral, varus, valgus) does not consider the orientation of the joint line or its relationship to the overall lower limb alignment. Similarly, current total knee arthroplasty (TKA) alignment concepts do not sufficiently conside...
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creator | Hirschmann, Michael T. Moser, Lukas B. Amsler, Felix Behrend, Henrik Leclerq, Vincent Hess, Silvan |
description | Purpose
The currently used system to classify the lower limb alignment (neutral, varus, valgus) does not consider the orientation of the joint line or its relationship to the overall lower limb alignment. Similarly, current total knee arthroplasty (TKA) alignment concepts do not sufficiently consider the variability of the native coronal alignment. Therefore, the purpose of this study was (1) to introduce a new classification system for the lower limb alignment, based on phenotypes, and (2) to compare the alignment targets of different TKA alignment concepts with the native alignment of non-osteoarthritic patients.
Methods
Two recent articles phenotyped the lower limb, the femur and tibia of 308 non-osteoarthritic knees of 160 patients [male to female ratio = 102:58, mean age ± standard deviation 30 ± 7 years (16–44 years)]. The present study introduces functional knee phenotypes, which are a combination of all previously introduced phenotypes. The functional knee phenotypes therefore enable an evaluation of all parameters in relation to each other and thus a comprehensive analysis of the coronal alignment. The existing functional knee phenotypes in the female and male population were investigated. In addition, how many non-osteoarthritic knees had an alignment within the range of current TKA alignment targets (mechanical, anatomical and restricted kinematic alignment) was investigated. Therefore, it was defined which functional knee phenotypes represented a target of the TKA alignment concepts and which percentage of the population had such a phenotype.
Results
Out of 125 possible functional knee phenotypes, 43 were found (35 male, 26 and 18 mutual). The most common functional knee phenotype in males was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (19%), followed by VAR
HKA
3° + NEU
FMA
0° + VAR
TMA
0° (8.2%). The most common functional knee phenotype in females was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (17.7%), closely followed by NEU
HKA
0° + NEU
FMA
0° + VAL
TMA
0° (16.6%). The functional knee phenotype representing a mechanical alignment target was found in 5.6% of the males and 3.6% of the females. The phenotype representing an anatomical alignment target was found in 18% of the males and 17% in females. Five of the nine phenotypes representing a restricted kinematic alignment target were found in this population (male 5, female 4, mutual 4). They represented 31.3% of all males and 45.1% of all females.
Conclusion
A more individualized approach to TKA alignm |
doi_str_mv | 10.1007/s00167-019-05509-z |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2209604712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2209604712</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-e0b90ffbc5374a77942307a87fd6be940731842e5dcac68b740b6b38190bae0a3</originalsourceid><addsrcrecordid>eNp9kcFu1DAURS1ERYfCD7BAltiwCTzHThyzQxUFpEpsytqyPS8zLokd7KRo-kF8J56Z0qIuWNnSO_dYz5eQVwzeMQD5PgOwVlbAVAVNA6q6fUJWTHBeSS7kU7ICJeqqhqY9Jc9zvgYoV6GekVMOSrZd3azI74sluNnHYAb6IyDSaYshzrsJ8wdqaIg3OFA3mJx9753Zk7SP6R7zYUPnLVIX08ExxF-Y6OBHS83gN2HEMFNrMq5pSe7JUCQ3-M_UB7qLS_GEGKqYZ4wmzdvkZ-_oVODC5BfkpDdDxpd35xn5fvHp6vxLdfnt89fzj5eVE4LNFYJV0PfWNVwKI2XZn4M0nezXrUUlQHLWiRqbtTOu7awUYFvLO6bAGgTDz8jbo3dK8eeCedajzw6HwQSMS9Z1DaoFIVld0DeP0Ou4pPIHB0q2TcsFK1R9pFyKOSfs9ZT8aNJOM9D7FvWxRV1a1IcW9W0Jvb5TL3bE9X3kb20F4Ecgl1HYYHp4-z_aP-bErHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2207656341</pqid></control><display><type>article</type><title>Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients</title><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals</source><creator>Hirschmann, Michael T. ; Moser, Lukas B. ; Amsler, Felix ; Behrend, Henrik ; Leclerq, Vincent ; Hess, Silvan</creator><creatorcontrib>Hirschmann, Michael T. ; Moser, Lukas B. ; Amsler, Felix ; Behrend, Henrik ; Leclerq, Vincent ; Hess, Silvan</creatorcontrib><description>Purpose
The currently used system to classify the lower limb alignment (neutral, varus, valgus) does not consider the orientation of the joint line or its relationship to the overall lower limb alignment. Similarly, current total knee arthroplasty (TKA) alignment concepts do not sufficiently consider the variability of the native coronal alignment. Therefore, the purpose of this study was (1) to introduce a new classification system for the lower limb alignment, based on phenotypes, and (2) to compare the alignment targets of different TKA alignment concepts with the native alignment of non-osteoarthritic patients.
Methods
Two recent articles phenotyped the lower limb, the femur and tibia of 308 non-osteoarthritic knees of 160 patients [male to female ratio = 102:58, mean age ± standard deviation 30 ± 7 years (16–44 years)]. The present study introduces functional knee phenotypes, which are a combination of all previously introduced phenotypes. The functional knee phenotypes therefore enable an evaluation of all parameters in relation to each other and thus a comprehensive analysis of the coronal alignment. The existing functional knee phenotypes in the female and male population were investigated. In addition, how many non-osteoarthritic knees had an alignment within the range of current TKA alignment targets (mechanical, anatomical and restricted kinematic alignment) was investigated. Therefore, it was defined which functional knee phenotypes represented a target of the TKA alignment concepts and which percentage of the population had such a phenotype.
Results
Out of 125 possible functional knee phenotypes, 43 were found (35 male, 26 and 18 mutual). The most common functional knee phenotype in males was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (19%), followed by VAR
HKA
3° + NEU
FMA
0° + VAR
TMA
0° (8.2%). The most common functional knee phenotype in females was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (17.7%), closely followed by NEU
HKA
0° + NEU
FMA
0° + VAL
TMA
0° (16.6%). The functional knee phenotype representing a mechanical alignment target was found in 5.6% of the males and 3.6% of the females. The phenotype representing an anatomical alignment target was found in 18% of the males and 17% in females. Five of the nine phenotypes representing a restricted kinematic alignment target were found in this population (male 5, female 4, mutual 4). They represented 31.3% of all males and 45.1% of all females.
Conclusion
A more individualized approach to TKA alignment is needed. The functional knee phenotypes enable a simple, but detailed assessment of a patient’s individual anatomy and thereby could be a helpful tool to individualize the approach to TKA.
Level of clinical evidence
III, retrospective cohort study.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-019-05509-z</identifier><identifier>PMID: 30976825</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alignment ; Arthroplasty (knee) ; Biocompatibility ; Classification ; Females ; Femur ; Genotype & phenotype ; Joint surgery ; Kinematics ; Knee ; Males ; Medicine ; Medicine & Public Health ; Orthopedics ; Osteoarthritis ; Patients ; Phenotypes ; Phenotyping ; Surgical implants ; Tibia</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019-05, Vol.27 (5), p.1394-1402</ispartof><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2019</rights><rights>Knee Surgery, Sports Traumatology, Arthroscopy is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e0b90ffbc5374a77942307a87fd6be940731842e5dcac68b740b6b38190bae0a3</citedby><cites>FETCH-LOGICAL-c441t-e0b90ffbc5374a77942307a87fd6be940731842e5dcac68b740b6b38190bae0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-019-05509-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-019-05509-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30976825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirschmann, Michael T.</creatorcontrib><creatorcontrib>Moser, Lukas B.</creatorcontrib><creatorcontrib>Amsler, Felix</creatorcontrib><creatorcontrib>Behrend, Henrik</creatorcontrib><creatorcontrib>Leclerq, Vincent</creatorcontrib><creatorcontrib>Hess, Silvan</creatorcontrib><title>Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Purpose
The currently used system to classify the lower limb alignment (neutral, varus, valgus) does not consider the orientation of the joint line or its relationship to the overall lower limb alignment. Similarly, current total knee arthroplasty (TKA) alignment concepts do not sufficiently consider the variability of the native coronal alignment. Therefore, the purpose of this study was (1) to introduce a new classification system for the lower limb alignment, based on phenotypes, and (2) to compare the alignment targets of different TKA alignment concepts with the native alignment of non-osteoarthritic patients.
Methods
Two recent articles phenotyped the lower limb, the femur and tibia of 308 non-osteoarthritic knees of 160 patients [male to female ratio = 102:58, mean age ± standard deviation 30 ± 7 years (16–44 years)]. The present study introduces functional knee phenotypes, which are a combination of all previously introduced phenotypes. The functional knee phenotypes therefore enable an evaluation of all parameters in relation to each other and thus a comprehensive analysis of the coronal alignment. The existing functional knee phenotypes in the female and male population were investigated. In addition, how many non-osteoarthritic knees had an alignment within the range of current TKA alignment targets (mechanical, anatomical and restricted kinematic alignment) was investigated. Therefore, it was defined which functional knee phenotypes represented a target of the TKA alignment concepts and which percentage of the population had such a phenotype.
Results
Out of 125 possible functional knee phenotypes, 43 were found (35 male, 26 and 18 mutual). The most common functional knee phenotype in males was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (19%), followed by VAR
HKA
3° + NEU
FMA
0° + VAR
TMA
0° (8.2%). The most common functional knee phenotype in females was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (17.7%), closely followed by NEU
HKA
0° + NEU
FMA
0° + VAL
TMA
0° (16.6%). The functional knee phenotype representing a mechanical alignment target was found in 5.6% of the males and 3.6% of the females. The phenotype representing an anatomical alignment target was found in 18% of the males and 17% in females. Five of the nine phenotypes representing a restricted kinematic alignment target were found in this population (male 5, female 4, mutual 4). They represented 31.3% of all males and 45.1% of all females.
Conclusion
A more individualized approach to TKA alignment is needed. The functional knee phenotypes enable a simple, but detailed assessment of a patient’s individual anatomy and thereby could be a helpful tool to individualize the approach to TKA.
Level of clinical evidence
III, retrospective cohort study.</description><subject>Alignment</subject><subject>Arthroplasty (knee)</subject><subject>Biocompatibility</subject><subject>Classification</subject><subject>Females</subject><subject>Femur</subject><subject>Genotype & phenotype</subject><subject>Joint surgery</subject><subject>Kinematics</subject><subject>Knee</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Patients</subject><subject>Phenotypes</subject><subject>Phenotyping</subject><subject>Surgical implants</subject><subject>Tibia</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kcFu1DAURS1ERYfCD7BAltiwCTzHThyzQxUFpEpsytqyPS8zLokd7KRo-kF8J56Z0qIuWNnSO_dYz5eQVwzeMQD5PgOwVlbAVAVNA6q6fUJWTHBeSS7kU7ICJeqqhqY9Jc9zvgYoV6GekVMOSrZd3azI74sluNnHYAb6IyDSaYshzrsJ8wdqaIg3OFA3mJx9753Zk7SP6R7zYUPnLVIX08ExxF-Y6OBHS83gN2HEMFNrMq5pSe7JUCQ3-M_UB7qLS_GEGKqYZ4wmzdvkZ-_oVODC5BfkpDdDxpd35xn5fvHp6vxLdfnt89fzj5eVE4LNFYJV0PfWNVwKI2XZn4M0nezXrUUlQHLWiRqbtTOu7awUYFvLO6bAGgTDz8jbo3dK8eeCedajzw6HwQSMS9Z1DaoFIVld0DeP0Ou4pPIHB0q2TcsFK1R9pFyKOSfs9ZT8aNJOM9D7FvWxRV1a1IcW9W0Jvb5TL3bE9X3kb20F4Ecgl1HYYHp4-z_aP-bErHw</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Hirschmann, Michael T.</creator><creator>Moser, Lukas B.</creator><creator>Amsler, Felix</creator><creator>Behrend, Henrik</creator><creator>Leclerq, Vincent</creator><creator>Hess, Silvan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients</title><author>Hirschmann, Michael T. ; Moser, Lukas B. ; Amsler, Felix ; Behrend, Henrik ; Leclerq, Vincent ; Hess, Silvan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e0b90ffbc5374a77942307a87fd6be940731842e5dcac68b740b6b38190bae0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alignment</topic><topic>Arthroplasty (knee)</topic><topic>Biocompatibility</topic><topic>Classification</topic><topic>Females</topic><topic>Femur</topic><topic>Genotype & phenotype</topic><topic>Joint surgery</topic><topic>Kinematics</topic><topic>Knee</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Patients</topic><topic>Phenotypes</topic><topic>Phenotyping</topic><topic>Surgical implants</topic><topic>Tibia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirschmann, Michael T.</creatorcontrib><creatorcontrib>Moser, Lukas B.</creatorcontrib><creatorcontrib>Amsler, Felix</creatorcontrib><creatorcontrib>Behrend, Henrik</creatorcontrib><creatorcontrib>Leclerq, Vincent</creatorcontrib><creatorcontrib>Hess, Silvan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirschmann, Michael T.</au><au>Moser, Lukas B.</au><au>Amsler, Felix</au><au>Behrend, Henrik</au><au>Leclerq, Vincent</au><au>Hess, Silvan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><stitle>Knee Surg Sports Traumatol Arthrosc</stitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>27</volume><issue>5</issue><spage>1394</spage><epage>1402</epage><pages>1394-1402</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>Purpose
The currently used system to classify the lower limb alignment (neutral, varus, valgus) does not consider the orientation of the joint line or its relationship to the overall lower limb alignment. Similarly, current total knee arthroplasty (TKA) alignment concepts do not sufficiently consider the variability of the native coronal alignment. Therefore, the purpose of this study was (1) to introduce a new classification system for the lower limb alignment, based on phenotypes, and (2) to compare the alignment targets of different TKA alignment concepts with the native alignment of non-osteoarthritic patients.
Methods
Two recent articles phenotyped the lower limb, the femur and tibia of 308 non-osteoarthritic knees of 160 patients [male to female ratio = 102:58, mean age ± standard deviation 30 ± 7 years (16–44 years)]. The present study introduces functional knee phenotypes, which are a combination of all previously introduced phenotypes. The functional knee phenotypes therefore enable an evaluation of all parameters in relation to each other and thus a comprehensive analysis of the coronal alignment. The existing functional knee phenotypes in the female and male population were investigated. In addition, how many non-osteoarthritic knees had an alignment within the range of current TKA alignment targets (mechanical, anatomical and restricted kinematic alignment) was investigated. Therefore, it was defined which functional knee phenotypes represented a target of the TKA alignment concepts and which percentage of the population had such a phenotype.
Results
Out of 125 possible functional knee phenotypes, 43 were found (35 male, 26 and 18 mutual). The most common functional knee phenotype in males was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (19%), followed by VAR
HKA
3° + NEU
FMA
0° + VAR
TMA
0° (8.2%). The most common functional knee phenotype in females was NEU
HKA
0° + NEU
FMA
0° + NEU
TMA
0° (17.7%), closely followed by NEU
HKA
0° + NEU
FMA
0° + VAL
TMA
0° (16.6%). The functional knee phenotype representing a mechanical alignment target was found in 5.6% of the males and 3.6% of the females. The phenotype representing an anatomical alignment target was found in 18% of the males and 17% in females. Five of the nine phenotypes representing a restricted kinematic alignment target were found in this population (male 5, female 4, mutual 4). They represented 31.3% of all males and 45.1% of all females.
Conclusion
A more individualized approach to TKA alignment is needed. The functional knee phenotypes enable a simple, but detailed assessment of a patient’s individual anatomy and thereby could be a helpful tool to individualize the approach to TKA.
Level of clinical evidence
III, retrospective cohort study.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30976825</pmid><doi>10.1007/s00167-019-05509-z</doi><tpages>9</tpages></addata></record> |
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language | eng |
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source | Wiley Online Library Journals Frontfile Complete; SpringerLink Journals |
subjects | Alignment Arthroplasty (knee) Biocompatibility Classification Females Femur Genotype & phenotype Joint surgery Kinematics Knee Males Medicine Medicine & Public Health Orthopedics Osteoarthritis Patients Phenotypes Phenotyping Surgical implants Tibia |
title | Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients |
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