Amino Acid Residues Recognizing Isomeric Glutamate Substrates in UDP‑N‑acetylmuramic acid‑l‑alanine-glutamate Synthetases

We recently revealed that a previously unknown pathway for peptidoglycan biosynthesis operates in some microorganisms, including Xanthomonas oryzae. It involves two enzymes, MurD2 and MurL, which catalyze the ligation of l-glutamate (l-Glu) to UDP-N-acetylmuramic acid-l-alanine and the epimerization...

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Veröffentlicht in:	ACS chemical biology 2019-05, Vol.14 (5), p.975-978
Hauptverfasser:	Feng, Ruoyin, Satoh, Yasuharu, Morita, Hiroyuki, Ogasawara, Yasushi, Dairi, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Glutamic Acid - chemistry Molecular Docking Simulation Mutation Peptide Synthases - chemistry Peptide Synthases - genetics Peptidoglycan - chemistry Stereoisomerism Streptococcus mutans - enzymology Substrate Specificity Xanthomonas - enzymology
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