NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn
Glioblastoma (GBM) is an incurable primary brain tumor that is highly resistant to current treatments. Glioma stem-like cells (GSCs) are an aggressive population of glioma cells that not only initiate malignant growth, but also promote therapeutic resistance. Thus, targeting GSCs is critical for imp...
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| Veröffentlicht in: | Cancer letters 2019-07, Vol.454, p.98-107 |
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| container_title | Cancer letters |
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| creator | Guo, Saisai Ran, Haowen Xiao, Dake Huang, Haohao Mi, Lanjuan Wang, Xinzheng Chen, Lishu Li, Da Zhang, Songyang Han, Qiuying Zhou, Tao Li, Ailing Man, Jianghong |
| description | Glioblastoma (GBM) is an incurable primary brain tumor that is highly resistant to current treatments. Glioma stem-like cells (GSCs) are an aggressive population of glioma cells that not only initiate malignant growth, but also promote therapeutic resistance. Thus, targeting GSCs is critical for improving GBM treatment and ensuring complete eradication of the tumor. Here, we show that NT5DC2 (5′-Nucleotidase Domain Containing 2), a functionally unknown protein, plays a crucial role in GSC tumor initiation via upregulating Fyn expression. NT5DC2 is preferentially expressed in GSCs relative to the non-stem tumor cells. Knockdown of NT5DC2 significantly inhibits the GSC tumorsphere formation and cell viability in vitro, and tumorigenesis in vivo, thus, prolonging animal survival. Moreover, disruption of NT5DC2 in GSCs markedly reduces the expression of Fyn, a Src family proto-oncogene that has been implicated in the regulation of GBM progression. Importantly, the expression of NT5DC2 strongly correlated with increased aggression of human gliomas, but not that of other brain tumors. Taken together, our results uncover the function of NT5DC2 in GSC maintenance and highlight NT5DC2 as a promising therapeutic target for GBM.
•NT5DC2 is preferentially expressed in glioma stem-like cells.•NT5DC2 promotes glioma stem-like cells tumorigenesis.•NT5DC2 up-regulates Fyn expression in glioma stem-like cells.•NT5DC2 correlates with glioma malignant progression and patient survival. |
| doi_str_mv | 10.1016/j.canlet.2019.04.003 |
| format | Article |
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•NT5DC2 is preferentially expressed in glioma stem-like cells.•NT5DC2 promotes glioma stem-like cells tumorigenesis.•NT5DC2 up-regulates Fyn expression in glioma stem-like cells.•NT5DC2 correlates with glioma malignant progression and patient survival.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2019.04.003</identifier><identifier>PMID: 30978441</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>5'-Nucleotidase - genetics ; 5'-Nucleotidase - metabolism ; Angiogenesis ; Animals ; Brain cancer ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Brain tumors ; Carcinogenesis ; Cell Growth Processes - physiology ; Cell viability ; Female ; Fyn ; Fyn protein ; Gene Expression Profiling ; Glioblastoma ; Glioma ; Glioma - genetics ; Glioma - metabolism ; Glioma - pathology ; Glioma cells ; Glioma Stem-like Cell ; Growth factors ; HEK293 Cells ; Heterografts ; Humans ; Kinases ; Laboratory animals ; Medical prognosis ; Melanoma ; Mice, Inbred BALB C ; Motility ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; NT5DC2 ; Nucleotidase ; Penicillin ; Protein Domains ; Proteins ; Proto-Oncogene Proteins c-fyn - genetics ; Proto-Oncogene Proteins c-fyn - metabolism ; Therapeutic applications ; Tumor cells ; Tumor Cells, Cultured ; Tumorigenesis ; Tumorigenicity ; Up-Regulation</subject><ispartof>Cancer letters, 2019-07, Vol.454, p.98-107</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>2019. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-2d42d38b8164d4c5d5c4208c453969b383fc0eeeac9ea71a1c11f90c43d34733</citedby><cites>FETCH-LOGICAL-c390t-2d42d38b8164d4c5d5c4208c453969b383fc0eeeac9ea71a1c11f90c43d34733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2019.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30978441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Saisai</creatorcontrib><creatorcontrib>Ran, Haowen</creatorcontrib><creatorcontrib>Xiao, Dake</creatorcontrib><creatorcontrib>Huang, Haohao</creatorcontrib><creatorcontrib>Mi, Lanjuan</creatorcontrib><creatorcontrib>Wang, Xinzheng</creatorcontrib><creatorcontrib>Chen, Lishu</creatorcontrib><creatorcontrib>Li, Da</creatorcontrib><creatorcontrib>Zhang, Songyang</creatorcontrib><creatorcontrib>Han, Qiuying</creatorcontrib><creatorcontrib>Zhou, Tao</creatorcontrib><creatorcontrib>Li, Ailing</creatorcontrib><creatorcontrib>Man, Jianghong</creatorcontrib><title>NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Glioblastoma (GBM) is an incurable primary brain tumor that is highly resistant to current treatments. Glioma stem-like cells (GSCs) are an aggressive population of glioma cells that not only initiate malignant growth, but also promote therapeutic resistance. Thus, targeting GSCs is critical for improving GBM treatment and ensuring complete eradication of the tumor. Here, we show that NT5DC2 (5′-Nucleotidase Domain Containing 2), a functionally unknown protein, plays a crucial role in GSC tumor initiation via upregulating Fyn expression. NT5DC2 is preferentially expressed in GSCs relative to the non-stem tumor cells. Knockdown of NT5DC2 significantly inhibits the GSC tumorsphere formation and cell viability in vitro, and tumorigenesis in vivo, thus, prolonging animal survival. Moreover, disruption of NT5DC2 in GSCs markedly reduces the expression of Fyn, a Src family proto-oncogene that has been implicated in the regulation of GBM progression. Importantly, the expression of NT5DC2 strongly correlated with increased aggression of human gliomas, but not that of other brain tumors. Taken together, our results uncover the function of NT5DC2 in GSC maintenance and highlight NT5DC2 as a promising therapeutic target for GBM.
•NT5DC2 is preferentially expressed in glioma stem-like cells.•NT5DC2 promotes glioma stem-like cells tumorigenesis.•NT5DC2 up-regulates Fyn expression in glioma stem-like cells.•NT5DC2 correlates with glioma malignant progression and patient survival.</description><subject>5'-Nucleotidase - genetics</subject><subject>5'-Nucleotidase - metabolism</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumors</subject><subject>Carcinogenesis</subject><subject>Cell Growth Processes - physiology</subject><subject>Cell viability</subject><subject>Female</subject><subject>Fyn</subject><subject>Fyn protein</subject><subject>Gene Expression Profiling</subject><subject>Glioblastoma</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Glioma cells</subject><subject>Glioma Stem-like Cell</subject><subject>Growth factors</subject><subject>HEK293 Cells</subject><subject>Heterografts</subject><subject>Humans</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Mice, Inbred BALB C</subject><subject>Motility</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>NT5DC2</subject><subject>Nucleotidase</subject><subject>Penicillin</subject><subject>Protein Domains</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-fyn - genetics</subject><subject>Proto-Oncogene Proteins c-fyn - metabolism</subject><subject>Therapeutic applications</subject><subject>Tumor cells</subject><subject>Tumor Cells, Cultured</subject><subject>Tumorigenesis</subject><subject>Tumorigenicity</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEUhUVJaZzHPwhFkE03M7l6zEObQnGaNGCSjfdC1twxcmZGrqQJ-N9XxkkXXXR1N9859_ARcsOgZMDqu11pzTRgKjkwVYIsAcQnsmBtw4tGtXBGFiBAFqIV1Tm5iHEHAJVsqi_kXIBqWinZgqye19X9ktN98KNPGGmaRx_cFidnXTpQ39Pt4PxoaEw4FoN7RWpxGCLdHOi8D7idB5PctKX9Yboin3szRLx-v5dk_fBzvfxVrF4en5Y_VoUVClLBO8k70W5aVstO2qqrrOTQWlkJVatNHtxbQERjFZqGGWYZ6xVYKTohGyEuybdTbR79e8aY9OjicZSZ0M9Rcw6qUqpmLKO3_6A7P4cpj8sUq7lUXNaZkifKBh9jwF7vgxtNOGgG-ihb7_RJtj7K1iB1lp1jX9_L582I3d_Qh90MfD8BmGW8OQw6WoeTxc4FtEl33v3_wx9EA5C4</recordid><startdate>20190710</startdate><enddate>20190710</enddate><creator>Guo, Saisai</creator><creator>Ran, Haowen</creator><creator>Xiao, Dake</creator><creator>Huang, Haohao</creator><creator>Mi, Lanjuan</creator><creator>Wang, Xinzheng</creator><creator>Chen, Lishu</creator><creator>Li, Da</creator><creator>Zhang, Songyang</creator><creator>Han, Qiuying</creator><creator>Zhou, Tao</creator><creator>Li, Ailing</creator><creator>Man, Jianghong</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20190710</creationdate><title>NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn</title><author>Guo, Saisai ; Ran, Haowen ; Xiao, Dake ; Huang, Haohao ; Mi, Lanjuan ; Wang, Xinzheng ; Chen, Lishu ; Li, Da ; Zhang, Songyang ; Han, Qiuying ; Zhou, Tao ; Li, Ailing ; Man, Jianghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-2d42d38b8164d4c5d5c4208c453969b383fc0eeeac9ea71a1c11f90c43d34733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>5'-Nucleotidase - genetics</topic><topic>5'-Nucleotidase - metabolism</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain tumors</topic><topic>Carcinogenesis</topic><topic>Cell Growth Processes - physiology</topic><topic>Cell viability</topic><topic>Female</topic><topic>Fyn</topic><topic>Fyn protein</topic><topic>Gene Expression Profiling</topic><topic>Glioblastoma</topic><topic>Glioma</topic><topic>Glioma - genetics</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Glioma cells</topic><topic>Glioma Stem-like Cell</topic><topic>Growth factors</topic><topic>HEK293 Cells</topic><topic>Heterografts</topic><topic>Humans</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Mice, Inbred BALB C</topic><topic>Motility</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>NT5DC2</topic><topic>Nucleotidase</topic><topic>Penicillin</topic><topic>Protein Domains</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-fyn - genetics</topic><topic>Proto-Oncogene Proteins c-fyn - metabolism</topic><topic>Therapeutic applications</topic><topic>Tumor cells</topic><topic>Tumor Cells, Cultured</topic><topic>Tumorigenesis</topic><topic>Tumorigenicity</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Saisai</creatorcontrib><creatorcontrib>Ran, Haowen</creatorcontrib><creatorcontrib>Xiao, Dake</creatorcontrib><creatorcontrib>Huang, Haohao</creatorcontrib><creatorcontrib>Mi, Lanjuan</creatorcontrib><creatorcontrib>Wang, Xinzheng</creatorcontrib><creatorcontrib>Chen, Lishu</creatorcontrib><creatorcontrib>Li, Da</creatorcontrib><creatorcontrib>Zhang, Songyang</creatorcontrib><creatorcontrib>Han, Qiuying</creatorcontrib><creatorcontrib>Zhou, Tao</creatorcontrib><creatorcontrib>Li, Ailing</creatorcontrib><creatorcontrib>Man, Jianghong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Saisai</au><au>Ran, Haowen</au><au>Xiao, Dake</au><au>Huang, Haohao</au><au>Mi, Lanjuan</au><au>Wang, Xinzheng</au><au>Chen, Lishu</au><au>Li, Da</au><au>Zhang, Songyang</au><au>Han, Qiuying</au><au>Zhou, Tao</au><au>Li, Ailing</au><au>Man, Jianghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2019-07-10</date><risdate>2019</risdate><volume>454</volume><spage>98</spage><epage>107</epage><pages>98-107</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Glioblastoma (GBM) is an incurable primary brain tumor that is highly resistant to current treatments. Glioma stem-like cells (GSCs) are an aggressive population of glioma cells that not only initiate malignant growth, but also promote therapeutic resistance. Thus, targeting GSCs is critical for improving GBM treatment and ensuring complete eradication of the tumor. Here, we show that NT5DC2 (5′-Nucleotidase Domain Containing 2), a functionally unknown protein, plays a crucial role in GSC tumor initiation via upregulating Fyn expression. NT5DC2 is preferentially expressed in GSCs relative to the non-stem tumor cells. Knockdown of NT5DC2 significantly inhibits the GSC tumorsphere formation and cell viability in vitro, and tumorigenesis in vivo, thus, prolonging animal survival. Moreover, disruption of NT5DC2 in GSCs markedly reduces the expression of Fyn, a Src family proto-oncogene that has been implicated in the regulation of GBM progression. Importantly, the expression of NT5DC2 strongly correlated with increased aggression of human gliomas, but not that of other brain tumors. Taken together, our results uncover the function of NT5DC2 in GSC maintenance and highlight NT5DC2 as a promising therapeutic target for GBM.
•NT5DC2 is preferentially expressed in glioma stem-like cells.•NT5DC2 promotes glioma stem-like cells tumorigenesis.•NT5DC2 up-regulates Fyn expression in glioma stem-like cells.•NT5DC2 correlates with glioma malignant progression and patient survival.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30978441</pmid><doi>10.1016/j.canlet.2019.04.003</doi><tpages>10</tpages></addata></record> |
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| subjects | 5'-Nucleotidase - genetics 5'-Nucleotidase - metabolism Angiogenesis Animals Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Carcinogenesis Cell Growth Processes - physiology Cell viability Female Fyn Fyn protein Gene Expression Profiling Glioblastoma Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Glioma Stem-like Cell Growth factors HEK293 Cells Heterografts Humans Kinases Laboratory animals Medical prognosis Melanoma Mice, Inbred BALB C Motility Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology NT5DC2 Nucleotidase Penicillin Protein Domains Proteins Proto-Oncogene Proteins c-fyn - genetics Proto-Oncogene Proteins c-fyn - metabolism Therapeutic applications Tumor cells Tumor Cells, Cultured Tumorigenesis Tumorigenicity Up-Regulation |
| title | NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn |
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