Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells

ABSTRACT The mechanism of exosomes derived from activated hepatic stellate cells (HSCs) involved in liver fibrosis is poorly understood. We previously reported that hypoxia‐inducible factor 1 (Hif‐1) regulated HSC activation, and, therefore, we investigated in current work whether Hif‐1 regulates ex...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2019-07, Vol.33 (7), p.8530-8542
Hauptverfasser:	Wan, Lu, Xia, Tian, Du, Yanqin, Liu, Jie, Xie, Yuyu, Zhang, Yijie, Guan, Fei, Wu, Jun, Wang, Xiaochuan, Shi, Chunwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Endothelial Cells - metabolism Exosomes - metabolism Glucose Transporter Type 1 - metabolism glycolysis Glycolysis - physiology hepatic fibrosis Hepatic Stellate Cells - metabolism Hepatocytes - metabolism Hif-1 Humans Kupffer Cells - metabolism Liver - metabolism Liver Cirrhosis - metabolism Mice Mice, Inbred BALB C Pyruvate Kinase - metabolism Signal Transduction - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!