Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study
Background Unintentional weight loss is frequently observed in cancer patients. Nutritional therapy is essential, and dietary counselling is the first step. The present study aimed to explore the nutrient intake and food patterns in weight‐stable and weight‐losing patients with non‐small cell lung c...
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| Veröffentlicht in: | Journal of human nutrition and dietetics 2019-10, Vol.32 (5), p.559-569 |
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| creator | Tobberup, R. Holst, M. Carus, A. Jensen, N. A. Falkmer, U. G. Rasmussen, H. H. |
| description | Background
Unintentional weight loss is frequently observed in cancer patients. Nutritional therapy is essential, and dietary counselling is the first step. The present study aimed to explore the nutrient intake and food patterns in weight‐stable and weight‐losing patients with non‐small cell lung cancer (NSCLC) during anti‐neoplastic treatment.
Methods
Patients with NSCLC (n = 62) were observed during first‐line systemic anti‐neoplastic treatment. Body weight and dietary intake were assessed on the first and second cycle, and after completing three cycles of treatment. Longitudinal changes were analysed in three groups: weight stable, weight losers and mixed weight.
Results
Nutrient intake did not change during treatment in weight stable, although weight losers significantly increased the relative protein intake. Weight stable maintained the food pattern during treatment apart from a decreased consumption of oral nutritional support (ONS). At baseline, weight losers were characterised by pretreatment weight loss, high consumption of ONS, as well as low consumption of grains and animal products. During treatment, weight losers increased the consumption of protein, fatty foods and ONS but decreased the consumption of sweets and alcohol.
Conclusions
Large heterogeneity in nutrient and food intake was observed in NSCLC patients during anti‐neoplastic treatment. Weight losers and weight stable had a similar nutrient intake although protein intake increased in weight losers. Grains and animal products were lower and ONS higher in weight losers compared to weight stable during treatment. Weight losers further increased the consumption of ONS and fatty foods, while the consumption of sweets and alcohol decreased during treatment. |
| doi_str_mv | 10.1111/jhn.12655 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2207936111</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2287221538</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-233cd9965cc6ba6ef6e02da19eaf1e6fe608bbefe7d8b26ecca1becdeda063fd3</originalsourceid><addsrcrecordid>eNp10c1u1DAQB3ALgei2cOAFkCUu9LCtPxQn4YYqoKAVXEDiFk3sSddLYi-2o2pvPAIvwMvxJEzYwgEJH-yx9NNfYw9jT6S4kLQud9twIZWpqntsJbWp1qquP99nK9FWaq2bWp6w05x3QggjhXjITrRoa9UYsWI_NjHc-DI7H2DkMBZMUHwMmfvAw1ySx1CoLvAFOQTHhxgd30MhGBZD5UIyv_Vly0MMP799zxOMI7dI2ziHG24hWEzczcnTDULxhALG_Qi5eMtLQigTpbzgwG3cxlR4pp4Oj9iDAcaMj-_OM_bp9auPV9frzYc3b69ebtZWV5qeq7V1bWsqa00PBgeDQjmQLcIg0QxoRNP3OGDtml4ZtBZkj9ahA2H04PQZe37M3af4dcZcusnnpX-gLufcKSXqVhv6a6LP_qG7OCf6vEU1tVKy0g2p86OyKeaccOj2yU-QDp0U3TKzjmbW_Z4Z2ad3iXM_ofsr_wyJwOUR3PoRD_9P6t5dvz9G_gKRBafA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2287221538</pqid></control><display><type>article</type><title>Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study</title><source>Access via Wiley Online Library</source><creator>Tobberup, R. ; Holst, M. ; Carus, A. ; Jensen, N. A. ; Falkmer, U. G. ; Rasmussen, H. H.</creator><creatorcontrib>Tobberup, R. ; Holst, M. ; Carus, A. ; Jensen, N. A. ; Falkmer, U. G. ; Rasmussen, H. H.</creatorcontrib><description>Background
Unintentional weight loss is frequently observed in cancer patients. Nutritional therapy is essential, and dietary counselling is the first step. The present study aimed to explore the nutrient intake and food patterns in weight‐stable and weight‐losing patients with non‐small cell lung cancer (NSCLC) during anti‐neoplastic treatment.
Methods
Patients with NSCLC (n = 62) were observed during first‐line systemic anti‐neoplastic treatment. Body weight and dietary intake were assessed on the first and second cycle, and after completing three cycles of treatment. Longitudinal changes were analysed in three groups: weight stable, weight losers and mixed weight.
Results
Nutrient intake did not change during treatment in weight stable, although weight losers significantly increased the relative protein intake. Weight stable maintained the food pattern during treatment apart from a decreased consumption of oral nutritional support (ONS). At baseline, weight losers were characterised by pretreatment weight loss, high consumption of ONS, as well as low consumption of grains and animal products. During treatment, weight losers increased the consumption of protein, fatty foods and ONS but decreased the consumption of sweets and alcohol.
Conclusions
Large heterogeneity in nutrient and food intake was observed in NSCLC patients during anti‐neoplastic treatment. Weight losers and weight stable had a similar nutrient intake although protein intake increased in weight losers. Grains and animal products were lower and ONS higher in weight losers compared to weight stable during treatment. Weight losers further increased the consumption of ONS and fatty foods, while the consumption of sweets and alcohol decreased during treatment.</description><identifier>ISSN: 0952-3871</identifier><identifier>EISSN: 1365-277X</identifier><identifier>DOI: 10.1111/jhn.12655</identifier><identifier>PMID: 30972860</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Alcohol ; Alcohols ; Animal products ; Body weight ; Body weight loss ; cancer ; Cohort analysis ; Consumption ; Diet ; Dietary intake ; dietary pattern ; Food ; Food consumption ; Food intake ; Grain ; Heterogeneity ; Longitude ; Lung cancer ; Non-small cell lung carcinoma ; Nutrients ; nutrition ; Nutrition therapy ; Pretreatment ; Proteins ; Weight loss</subject><ispartof>Journal of human nutrition and dietetics, 2019-10, Vol.32 (5), p.559-569</ispartof><rights>2019 The British Dietetic Association Ltd.</rights><rights>2019 The British Dietetic Association Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-233cd9965cc6ba6ef6e02da19eaf1e6fe608bbefe7d8b26ecca1becdeda063fd3</citedby><cites>FETCH-LOGICAL-c3535-233cd9965cc6ba6ef6e02da19eaf1e6fe608bbefe7d8b26ecca1becdeda063fd3</cites><orcidid>0000-0001-9369-8628 ; 0000-0002-9245-7678 ; 0000-0002-9425-2318 ; 0000-0002-7458-9458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjhn.12655$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjhn.12655$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30972860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tobberup, R.</creatorcontrib><creatorcontrib>Holst, M.</creatorcontrib><creatorcontrib>Carus, A.</creatorcontrib><creatorcontrib>Jensen, N. A.</creatorcontrib><creatorcontrib>Falkmer, U. G.</creatorcontrib><creatorcontrib>Rasmussen, H. H.</creatorcontrib><title>Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study</title><title>Journal of human nutrition and dietetics</title><addtitle>J Hum Nutr Diet</addtitle><description>Background
Unintentional weight loss is frequently observed in cancer patients. Nutritional therapy is essential, and dietary counselling is the first step. The present study aimed to explore the nutrient intake and food patterns in weight‐stable and weight‐losing patients with non‐small cell lung cancer (NSCLC) during anti‐neoplastic treatment.
Methods
Patients with NSCLC (n = 62) were observed during first‐line systemic anti‐neoplastic treatment. Body weight and dietary intake were assessed on the first and second cycle, and after completing three cycles of treatment. Longitudinal changes were analysed in three groups: weight stable, weight losers and mixed weight.
Results
Nutrient intake did not change during treatment in weight stable, although weight losers significantly increased the relative protein intake. Weight stable maintained the food pattern during treatment apart from a decreased consumption of oral nutritional support (ONS). At baseline, weight losers were characterised by pretreatment weight loss, high consumption of ONS, as well as low consumption of grains and animal products. During treatment, weight losers increased the consumption of protein, fatty foods and ONS but decreased the consumption of sweets and alcohol.
Conclusions
Large heterogeneity in nutrient and food intake was observed in NSCLC patients during anti‐neoplastic treatment. Weight losers and weight stable had a similar nutrient intake although protein intake increased in weight losers. Grains and animal products were lower and ONS higher in weight losers compared to weight stable during treatment. Weight losers further increased the consumption of ONS and fatty foods, while the consumption of sweets and alcohol decreased during treatment.</description><subject>Alcohol</subject><subject>Alcohols</subject><subject>Animal products</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>cancer</subject><subject>Cohort analysis</subject><subject>Consumption</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>dietary pattern</subject><subject>Food</subject><subject>Food consumption</subject><subject>Food intake</subject><subject>Grain</subject><subject>Heterogeneity</subject><subject>Longitude</subject><subject>Lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Nutrients</subject><subject>nutrition</subject><subject>Nutrition therapy</subject><subject>Pretreatment</subject><subject>Proteins</subject><subject>Weight loss</subject><issn>0952-3871</issn><issn>1365-277X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10c1u1DAQB3ALgei2cOAFkCUu9LCtPxQn4YYqoKAVXEDiFk3sSddLYi-2o2pvPAIvwMvxJEzYwgEJH-yx9NNfYw9jT6S4kLQud9twIZWpqntsJbWp1qquP99nK9FWaq2bWp6w05x3QggjhXjITrRoa9UYsWI_NjHc-DI7H2DkMBZMUHwMmfvAw1ySx1CoLvAFOQTHhxgd30MhGBZD5UIyv_Vly0MMP799zxOMI7dI2ziHG24hWEzczcnTDULxhALG_Qi5eMtLQigTpbzgwG3cxlR4pp4Oj9iDAcaMj-_OM_bp9auPV9frzYc3b69ebtZWV5qeq7V1bWsqa00PBgeDQjmQLcIg0QxoRNP3OGDtml4ZtBZkj9ahA2H04PQZe37M3af4dcZcusnnpX-gLufcKSXqVhv6a6LP_qG7OCf6vEU1tVKy0g2p86OyKeaccOj2yU-QDp0U3TKzjmbW_Z4Z2ad3iXM_ofsr_wyJwOUR3PoRD_9P6t5dvz9G_gKRBafA</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Tobberup, R.</creator><creator>Holst, M.</creator><creator>Carus, A.</creator><creator>Jensen, N. A.</creator><creator>Falkmer, U. G.</creator><creator>Rasmussen, H. H.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9369-8628</orcidid><orcidid>https://orcid.org/0000-0002-9245-7678</orcidid><orcidid>https://orcid.org/0000-0002-9425-2318</orcidid><orcidid>https://orcid.org/0000-0002-7458-9458</orcidid></search><sort><creationdate>201910</creationdate><title>Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study</title><author>Tobberup, R. ; Holst, M. ; Carus, A. ; Jensen, N. A. ; Falkmer, U. G. ; Rasmussen, H. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-233cd9965cc6ba6ef6e02da19eaf1e6fe608bbefe7d8b26ecca1becdeda063fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Alcohols</topic><topic>Animal products</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>cancer</topic><topic>Cohort analysis</topic><topic>Consumption</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>dietary pattern</topic><topic>Food</topic><topic>Food consumption</topic><topic>Food intake</topic><topic>Grain</topic><topic>Heterogeneity</topic><topic>Longitude</topic><topic>Lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Nutrients</topic><topic>nutrition</topic><topic>Nutrition therapy</topic><topic>Pretreatment</topic><topic>Proteins</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tobberup, R.</creatorcontrib><creatorcontrib>Holst, M.</creatorcontrib><creatorcontrib>Carus, A.</creatorcontrib><creatorcontrib>Jensen, N. A.</creatorcontrib><creatorcontrib>Falkmer, U. G.</creatorcontrib><creatorcontrib>Rasmussen, H. H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human nutrition and dietetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tobberup, R.</au><au>Holst, M.</au><au>Carus, A.</au><au>Jensen, N. A.</au><au>Falkmer, U. G.</au><au>Rasmussen, H. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study</atitle><jtitle>Journal of human nutrition and dietetics</jtitle><addtitle>J Hum Nutr Diet</addtitle><date>2019-10</date><risdate>2019</risdate><volume>32</volume><issue>5</issue><spage>559</spage><epage>569</epage><pages>559-569</pages><issn>0952-3871</issn><eissn>1365-277X</eissn><abstract>Background
Unintentional weight loss is frequently observed in cancer patients. Nutritional therapy is essential, and dietary counselling is the first step. The present study aimed to explore the nutrient intake and food patterns in weight‐stable and weight‐losing patients with non‐small cell lung cancer (NSCLC) during anti‐neoplastic treatment.
Methods
Patients with NSCLC (n = 62) were observed during first‐line systemic anti‐neoplastic treatment. Body weight and dietary intake were assessed on the first and second cycle, and after completing three cycles of treatment. Longitudinal changes were analysed in three groups: weight stable, weight losers and mixed weight.
Results
Nutrient intake did not change during treatment in weight stable, although weight losers significantly increased the relative protein intake. Weight stable maintained the food pattern during treatment apart from a decreased consumption of oral nutritional support (ONS). At baseline, weight losers were characterised by pretreatment weight loss, high consumption of ONS, as well as low consumption of grains and animal products. During treatment, weight losers increased the consumption of protein, fatty foods and ONS but decreased the consumption of sweets and alcohol.
Conclusions
Large heterogeneity in nutrient and food intake was observed in NSCLC patients during anti‐neoplastic treatment. Weight losers and weight stable had a similar nutrient intake although protein intake increased in weight losers. Grains and animal products were lower and ONS higher in weight losers compared to weight stable during treatment. Weight losers further increased the consumption of ONS and fatty foods, while the consumption of sweets and alcohol decreased during treatment.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30972860</pmid><doi>10.1111/jhn.12655</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9369-8628</orcidid><orcidid>https://orcid.org/0000-0002-9245-7678</orcidid><orcidid>https://orcid.org/0000-0002-9425-2318</orcidid><orcidid>https://orcid.org/0000-0002-7458-9458</orcidid></addata></record> |
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| ispartof | Journal of human nutrition and dietetics, 2019-10, Vol.32 (5), p.559-569 |
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| subjects | Alcohol Alcohols Animal products Body weight Body weight loss cancer Cohort analysis Consumption Diet Dietary intake dietary pattern Food Food consumption Food intake Grain Heterogeneity Longitude Lung cancer Non-small cell lung carcinoma Nutrients nutrition Nutrition therapy Pretreatment Proteins Weight loss |
| title | Longitudinal alterations in nutrient intake and food pattern in patients with non‐small cell lung cancer during anti‐neoplastic treatment: a cohort study |
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