An extendable all-in-one injection twin derivatization LC-MS/MS strategy for the absolute quantification of multiple chemical-group-based submetabolomes

The ability of LC-MS/MS for high coverage metabolite analysis lags behind the requirements of global metabolomics. The introduction of chemical derivatizations could significantly extend the ability of LC-MS/MS with enhanced MS response and improved LC separation, which has been serving as a promisi...

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Veröffentlicht in:	Analytica chimica acta 2019-07, Vol.1063, p.99-109
Hauptverfasser:	Huang, Yezhen, Jiao, Yu, Gao, Yiqiao, Zhang, Pei, Huang, Wanqiu, Liu, Yong, Huang, Yin, Tian, Yuan, Wan, Jian-Bo, Zhang, Zunjian, Hao, Kun, Xu, Fengguo
Format:	Artikel
Sprache:	eng
Schlagworte:	All-in-one injection strategy Amino acids Amino Acids - blood Amino Acids - metabolism Animals Bile acids Bile Acids and Salts - blood Bile Acids and Salts - metabolism Chlorides Chromatography, Liquid Dens Disease Models, Animal Fatty acids Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Indoles Indoles - blood Indoles - metabolism Injection Irinotecan Irinotecan - toxicity Liquid chromatography‒Tandem mass spectrometry Metabolites Metabolomics Metabolomics - instrumentation Metabolomics - methods Microorganisms Multiple submetabolomes absolute quantification Naphthalene Organic chemistry Phenols Piperazine Polyamines Polyamines - blood Polyamines - metabolism Rats Reagents Strategy Tandem Mass Spectrometry Toxicity Twins derivatization
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