Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor–Transgenic Mouse Model of Rheumatoid Arthritis

Objective To examine and quantify the sexual dimorphism in pathologic features manifested in the musculoskeletal and cardiopulmonary systems and incidence of mortality in the tumor necrosis factor–transgenic (TNF‐Tg; Tg3647 strain) mouse model of inflammatory erosive arthritis. Methods Kaplan‐Meier...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2019-09, Vol.71 (9), p.1512-1523
Hauptverfasser:	Bell, Richard D., Wu, Emily K., Rudmann, Christopher A., Forney, Megan, Kaiser, Claire R. W., Wood, Ronald W., Chakkalakal, Joe V., Paris, Nicole D., Klose, Alanna, Xiao, Guang‐Qian, Rangel‐Moreno, Javier, Garcia‐Hernandez, Maria L., Ritchlin, Christopher T., Schwarz, Edward M., Rahimi, Homaira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - mortality Arthritis, Rheumatoid - pathology Axial skeleton Body mass Bone growth Bone loss Computed tomography Connective tissue diseases Connective tissues Disease Models, Animal Disease Progression Female Flow Cytometry Grip strength Heart Hypertrophy Incidence Longitude Lung diseases Lung Diseases, Interstitial - etiology Male Mice Mice, Transgenic Mortality Muscles Musculoskeletal System - pathology Necrosis Respiratory System - pathology Rheumatoid arthritis Rodents Sex Sex Characteristics Sexual dimorphism Skeletal muscle Thickening Transgenic mice Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumors Ultrasound Ventricle X-Ray Microtomography
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