Diabetes-Related Complications and Mortality in Patients With Young-Onset Latent Autoimmune Diabetes: A 14-Year Analysis of the Prospective Hong Kong Diabetes Register

Diabetes-Related Complications and Mortality in Patients With Young-Onset Latent Autoimmune Diabetes: A 14-Year Analysis of the Prospective Hong Kong Diabetes Register

Young-onset diabetes is heterogeneous in etiology and disease progression. We compared the incidence of diabetes-related complications and mortality in patients with young-onset type 2 diabetes with or without anti-GAD antibodies and patients with type 1 diabetes. We determined changes in glycemic c...

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Veröffentlicht in:Diabetes care 2019-06, Vol.42 (6), p.1042-1050
Hauptverfasser: Luk, Andrea O Y, Lau, Eric S H, Lim, Cadmon, Kong, Alice P S, Chow, Elaine, Ma, Ronald C W, Chan, Juliana C N
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age of Onset
Antibodies
Autoimmune diseases
Cardiovascular diseases
Complications
Diabetes
Diabetes Complications - epidemiology
Diabetes Complications - mortality
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - mortality
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - mortality
End-stage renal disease
Etiology
Female
Glucose monitoring
Glutamate decarboxylase
Hazards
Health hazards
Hong Kong - epidemiology
Humans
Hypoglycemia
Immunoglobulins
Incidence
Insulin
Kidney diseases
Latent Autoimmune Diabetes in Adults - complications
Latent Autoimmune Diabetes in Adults - epidemiology
Latent Autoimmune Diabetes in Adults - mortality
Male
Middle Aged
Mortality
Prospective Studies
Registries
Regression analysis
Research design
Young Adult
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Zusammenfassung:Young-onset diabetes is heterogeneous in etiology and disease progression. We compared the incidence of diabetes-related complications and mortality in patients with young-onset type 2 diabetes with or without anti-GAD antibodies and patients with type 1 diabetes. We determined changes in glycemic control before and after commencement of insulin therapy stratified by antibody status. Between 1994 and 2012, 1,504 consecutively enrolled patients with type 2 diabetes who had received a diagnosis at
ISSN:0149-5992
1935-5548
DOI:10.2337/dc18-1796