Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats
The intravenous administration of an amino acid (AA) mixture during general anesthesia reduces anesthesia-induced hypothermia. AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary prote...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2019-05, Vol.65, p.79-88 |
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| creator | Kanazawa, Masahiro Watanabe, Mariko Suzuki, Toshiyasu |
| description | The intravenous administration of an amino acid (AA) mixture during general anesthesia reduces anesthesia-induced hypothermia. AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Sprague-Dawley rats were divided into 4 groups: fed a control diet plus saline (CON-SAL) or the AA mixture (CON-AA), and fed a protein-free diet plus saline (PF-SAL) or the AA mixture (PF-AA). SAL solution or AA mixture solution was infused for 180 minutes during sevoflurane anesthesia, and rectal temperatures were measured. Rectal temperatures were significantly higher in the CON-AA group than in the PF-AA group 90 to 180 minutes after initiating the intravenous infusion of the test solutions. There was no significant difference between the PF-SAL and PF-AA groups. Plasma insulin concentrations were significantly higher in the CON-AA group than in the PF-AA group (P |
| doi_str_mv | 10.1016/j.nutres.2019.02.007 |
| format | Article |
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AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Sprague-Dawley rats were divided into 4 groups: fed a control diet plus saline (CON-SAL) or the AA mixture (CON-AA), and fed a protein-free diet plus saline (PF-SAL) or the AA mixture (PF-AA). SAL solution or AA mixture solution was infused for 180 minutes during sevoflurane anesthesia, and rectal temperatures were measured. Rectal temperatures were significantly higher in the CON-AA group than in the PF-AA group 90 to 180 minutes after initiating the intravenous infusion of the test solutions. There was no significant difference between the PF-SAL and PF-AA groups. Plasma insulin concentrations were significantly higher in the CON-AA group than in the PF-AA group (P < .05). The phosphorylation states of protein kinase B, mammalian target of rapamycin, and eukaryotic initiation factor 4E-binding protein 1 were significantly greater in the CON-AA group than in the PF-AA group (P < .05, P < .05, and P < .01, respectively). Our results indicated that a dietary protein deficiency before general anesthesia impaired the antihypothermic effects of an AA mixture infusion during general anesthesia by decreasing muscle protein synthesis through the insulin-stimulated phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin complex 1 signaling pathway followed by metabolic heat production.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2019.02.007</identifier><identifier>PMID: 30967292</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino acids ; Anesthesia ; Dietary protein ; Hypothermia ; Metabolic heat production ; Thermogenesis</subject><ispartof>Nutrition research (New York, N.Y.), 2019-05, Vol.65, p.79-88</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. 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AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Sprague-Dawley rats were divided into 4 groups: fed a control diet plus saline (CON-SAL) or the AA mixture (CON-AA), and fed a protein-free diet plus saline (PF-SAL) or the AA mixture (PF-AA). SAL solution or AA mixture solution was infused for 180 minutes during sevoflurane anesthesia, and rectal temperatures were measured. Rectal temperatures were significantly higher in the CON-AA group than in the PF-AA group 90 to 180 minutes after initiating the intravenous infusion of the test solutions. There was no significant difference between the PF-SAL and PF-AA groups. Plasma insulin concentrations were significantly higher in the CON-AA group than in the PF-AA group (P < .05). The phosphorylation states of protein kinase B, mammalian target of rapamycin, and eukaryotic initiation factor 4E-binding protein 1 were significantly greater in the CON-AA group than in the PF-AA group (P < .05, P < .05, and P < .01, respectively). Our results indicated that a dietary protein deficiency before general anesthesia impaired the antihypothermic effects of an AA mixture infusion during general anesthesia by decreasing muscle protein synthesis through the insulin-stimulated phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin complex 1 signaling pathway followed by metabolic heat production.</description><subject>Amino acids</subject><subject>Anesthesia</subject><subject>Dietary protein</subject><subject>Hypothermia</subject><subject>Metabolic heat production</subject><subject>Thermogenesis</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQQEVoaDZp_0EIOvZidyTZVnQplNAmhYX2kJyFLI13tdjyRpIX8u-j7SY99jQw8-brEXLNoGbAuq-7Oiw5Yqo5MFUDrwHkGVmxW6kqkEJ9ICvgklWtYPKCXKa0A2CSCfGRXAhQneSKr8j-T5wz-kAnMx7n-eznQPcRDxhyols0mdo5JIwH87fkg1ssOtq_UDP5MFNjvSvZYUnHsluiDxu6wYDRjNQETHmLyZuC0Ghy-kTOBzMm_PwWr8jTzx-Pdw_V-vf9r7vv68oKxnKlxADMWOxlD71qG7Sq4VbxwTrGe7CSN92g8FZx6JxyAqXsROOk4h0r33fiinw5zd3H-XkpV-jJJ4vjWE6al6Q5B8la2fK2oM0JtXFOKeKg99FPJr5oBvroWu_0ybU-utbAdXFd2m7eNiz9hO5f07vcAnw7AVj-PHiMOlmPodjzEW3Wbvb_3_AKUT6UIQ</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Kanazawa, Masahiro</creator><creator>Watanabe, Mariko</creator><creator>Suzuki, Toshiyasu</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201905</creationdate><title>Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats</title><author>Kanazawa, Masahiro ; Watanabe, Mariko ; Suzuki, Toshiyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-93f01aceb7b0b954ec942c92fcd12b0c7246f9e89206d9d3e77634d7926107363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amino acids</topic><topic>Anesthesia</topic><topic>Dietary protein</topic><topic>Hypothermia</topic><topic>Metabolic heat production</topic><topic>Thermogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanazawa, Masahiro</creatorcontrib><creatorcontrib>Watanabe, Mariko</creatorcontrib><creatorcontrib>Suzuki, Toshiyasu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanazawa, Masahiro</au><au>Watanabe, Mariko</au><au>Suzuki, Toshiyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2019-05</date><risdate>2019</risdate><volume>65</volume><spage>79</spage><epage>88</epage><pages>79-88</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><abstract>The intravenous administration of an amino acid (AA) mixture during general anesthesia reduces anesthesia-induced hypothermia. AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Sprague-Dawley rats were divided into 4 groups: fed a control diet plus saline (CON-SAL) or the AA mixture (CON-AA), and fed a protein-free diet plus saline (PF-SAL) or the AA mixture (PF-AA). SAL solution or AA mixture solution was infused for 180 minutes during sevoflurane anesthesia, and rectal temperatures were measured. Rectal temperatures were significantly higher in the CON-AA group than in the PF-AA group 90 to 180 minutes after initiating the intravenous infusion of the test solutions. There was no significant difference between the PF-SAL and PF-AA groups. Plasma insulin concentrations were significantly higher in the CON-AA group than in the PF-AA group (P < .05). The phosphorylation states of protein kinase B, mammalian target of rapamycin, and eukaryotic initiation factor 4E-binding protein 1 were significantly greater in the CON-AA group than in the PF-AA group (P < .05, P < .05, and P < .01, respectively). Our results indicated that a dietary protein deficiency before general anesthesia impaired the antihypothermic effects of an AA mixture infusion during general anesthesia by decreasing muscle protein synthesis through the insulin-stimulated phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin complex 1 signaling pathway followed by metabolic heat production.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30967292</pmid><doi>10.1016/j.nutres.2019.02.007</doi><tpages>10</tpages></addata></record> |
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| subjects | Amino acids Anesthesia Dietary protein Hypothermia Metabolic heat production Thermogenesis |
| title | Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats |
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