Important roles of protein tyrosine phosphatase PTPN12 in tumor progression
[Display omitted] Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mec...
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| Veröffentlicht in: | Pharmacological research 2019-06, Vol.144, p.73-78 |
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| container_title | Pharmacological research |
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| creator | Lee, Chaelin Rhee, Inmoo |
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Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphorylation of multiple targets and are associated with the onset of various autoimmune diseases through genomic alterations. PTPs also affect disease through their role in innate and/or acquired immunity. By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion. According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss the critical roles of PTPN12/PTP-PEST in tumor progression. |
| doi_str_mv | 10.1016/j.phrs.2019.04.011 |
| format | Article |
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Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphorylation of multiple targets and are associated with the onset of various autoimmune diseases through genomic alterations. PTPs also affect disease through their role in innate and/or acquired immunity. By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion. According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss the critical roles of PTPN12/PTP-PEST in tumor progression.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2019.04.011</identifier><identifier>PMID: 30959160</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Breast cancer ; Disease Progression ; Drug Discovery ; Enzyme Inhibitors - pharmacology ; Humans ; Immunity - drug effects ; Inhibitors ; Molecular Targeted Therapy ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - pathology ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 - analysis ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 - antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology ; Protein tyrosine phosphatases ; PTPN12/PTP-PEST ; Signal transduction</subject><ispartof>Pharmacological research, 2019-06, Vol.144, p.73-78</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ef0ba7a9b01d72992b9c04ca2f0269e510fcbcf1c206509c91bdca1494e9d1863</citedby><cites>FETCH-LOGICAL-c356t-ef0ba7a9b01d72992b9c04ca2f0269e510fcbcf1c206509c91bdca1494e9d1863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043661819304955$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30959160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Chaelin</creatorcontrib><creatorcontrib>Rhee, Inmoo</creatorcontrib><title>Important roles of protein tyrosine phosphatase PTPN12 in tumor progression</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>[Display omitted]
Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphorylation of multiple targets and are associated with the onset of various autoimmune diseases through genomic alterations. PTPs also affect disease through their role in innate and/or acquired immunity. By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion. According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss the critical roles of PTPN12/PTP-PEST in tumor progression.</description><subject>Animals</subject><subject>Breast cancer</subject><subject>Disease Progression</subject><subject>Drug Discovery</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Inhibitors</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Phosphorylation</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - analysis</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - antagonists & inhibitors</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology</subject><subject>Protein tyrosine phosphatases</subject><subject>PTPN12/PTP-PEST</subject><subject>Signal transduction</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoPkb_gAvp0k3rvWkbDbgR8YWDzmJchzS9dTJMm5q0gv_elFGXrhLId044H2OnCBkCiot11q98yDigzKDIAHGHHSJIkSJeid3pXuSpEHh1wI5CWAOALBD22UEOspQo4JA9P7W984PuhsS7DYXENUnv3UC2S4Yv74LtKOlXLvQrPehAyWK5eEGeTM9j6_wEv3sKwbrumO01ehPo5Oecsbf7u-XtYzp_fXi6vZmnJi_FkFIDlb7UsgKsL7mUvJIGCqN5A1xIKhEaU5kGDQdRgjQSq9poLGRBso7D8hk73_bGvz9GCoNqbTC02eiO3BgUj0Ge8xyLiPItauKU4KlRvbet9l8KQU0S1VpNEtUkUUGhosQYOvvpH6uW6r_Ir7UIXG8Biis_LXkVjKXOUG09mUHVzv7X_w1CmIN_</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Lee, Chaelin</creator><creator>Rhee, Inmoo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201906</creationdate><title>Important roles of protein tyrosine phosphatase PTPN12 in tumor progression</title><author>Lee, Chaelin ; Rhee, Inmoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ef0ba7a9b01d72992b9c04ca2f0269e510fcbcf1c206509c91bdca1494e9d1863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Breast cancer</topic><topic>Disease Progression</topic><topic>Drug Discovery</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Immunity - drug effects</topic><topic>Inhibitors</topic><topic>Molecular Targeted Therapy</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Phosphorylation</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - analysis</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - antagonists & inhibitors</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology</topic><topic>Protein tyrosine phosphatases</topic><topic>PTPN12/PTP-PEST</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chaelin</creatorcontrib><creatorcontrib>Rhee, Inmoo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chaelin</au><au>Rhee, Inmoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Important roles of protein tyrosine phosphatase PTPN12 in tumor progression</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2019-06</date><risdate>2019</risdate><volume>144</volume><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>[Display omitted]
Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphorylation of multiple targets and are associated with the onset of various autoimmune diseases through genomic alterations. PTPs also affect disease through their role in innate and/or acquired immunity. By modulating multiple substrates, PTPN12, a member of the proline-, glutamic acid-, serine- and threonine-rich (PEST) family of PTPs, is an important regulator of cell migration and adhesion. According to its newly identified roles and functions, PTPN12 is considered a promising therapeutic target against critical diseases, including cancer, diabetes, metabolic disease and autoimmune diseases. In this review, we provide an overview of PTPs and discuss the critical roles of PTPN12/PTP-PEST in tumor progression.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30959160</pmid><doi>10.1016/j.phrs.2019.04.011</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Breast cancer Disease Progression Drug Discovery Enzyme Inhibitors - pharmacology Humans Immunity - drug effects Inhibitors Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 12 - analysis Protein Tyrosine Phosphatase, Non-Receptor Type 12 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology Protein tyrosine phosphatases PTPN12/PTP-PEST Signal transduction |
| title | Important roles of protein tyrosine phosphatase PTPN12 in tumor progression |
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