RhoA inhibitor suppresses the production of microvesicles and rescues high ventilation induced lung injury

Microvesicles (MVs) have been extensively identified in various biological fluids including bronchoalveolar lavage fluid (BALF), peripheral blood and ascitic fluids. Our previous study showed that MVs are responsible for acute lung injury, but the exact mechanism underlying MVs formation remains poo...

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Veröffentlicht in:	International immunopharmacology 2019-07, Vol.72, p.74-81
Hauptverfasser:	Dai, Huijun, Zhang, Suisui, Du, Xueke, Zhang, Weikang, Jing, Ren, Wang, Xiaoxia, Pan, Linghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Biological activity Bronchus High tide Inflammation Inhibitors Injuries Kinases Lung injury Lungs Mechanical ventilation Mice Microvesicles Peripheral blood Phosphorylation Rho-associated kinase RhoA protein RhoA/Rock signaling Rocks Signal transduction Signaling Trachea Ventilation Ventilator
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