Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders
•Neurodegenerative diseases onset and pathology are influenced by gender and genetic mechanisms.•Sex dimorphism occurs in virtually all neurodegenerative diseases.•Mitochondrial functions and epigenetic modifications are mechanisms triggering sex differences in neurodegenerative diseases. The impact...
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| Veröffentlicht in: | Neuroscience and biobehavioral reviews 2019-07, Vol.102, p.95-105 |
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| creator | Ullah, Mohammad Fahad Ahmad, Aamir Bhat, Showket Hussain Abu-Duhier, Faisel M. Barreto, George E. Ashraf, Ghulam Md |
| description | •Neurodegenerative diseases onset and pathology are influenced by gender and genetic mechanisms.•Sex dimorphism occurs in virtually all neurodegenerative diseases.•Mitochondrial functions and epigenetic modifications are mechanisms triggering sex differences in neurodegenerative diseases.
The impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a gender-dependent natural bias of neurodegenerative diseases, such as, Alzheimer's disease, Parkinson's disease, Huntington’s disease and multiple sclerosis, with the ratio of male to female prevalence as well as the severity of the disease differing significantly between the two sexes. This observation has recently garnered much attention and it is now being realized that understanding the sex as a biological variable in the etiology of the neurodegenerative diseases may advance the status of the pathophysiology and treatment strategies while improving the associated decline in cognitive and functional abilities. This review highlights the influence of gender in neurodegenerative disorders and further discusses the sex-specific pre-determined microenvironments that are critical in predisposing the individuals to such disorders. |
| doi_str_mv | 10.1016/j.neubiorev.2019.04.003 |
| format | Article |
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The impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a gender-dependent natural bias of neurodegenerative diseases, such as, Alzheimer's disease, Parkinson's disease, Huntington’s disease and multiple sclerosis, with the ratio of male to female prevalence as well as the severity of the disease differing significantly between the two sexes. This observation has recently garnered much attention and it is now being realized that understanding the sex as a biological variable in the etiology of the neurodegenerative diseases may advance the status of the pathophysiology and treatment strategies while improving the associated decline in cognitive and functional abilities. This review highlights the influence of gender in neurodegenerative disorders and further discusses the sex-specific pre-determined microenvironments that are critical in predisposing the individuals to such disorders.</description><identifier>ISSN: 0149-7634</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2019.04.003</identifier><identifier>PMID: 30959072</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Alzheimer Disease - epidemiology ; Alzheimer Disease - metabolism ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Brain - metabolism ; Brain - physiopathology ; Cognitive impairment ; Epigenesis, Genetic - physiology ; Gender bias ; Humans ; Huntington Disease - epidemiology ; Huntington Disease - metabolism ; Huntington Disease - physiopathology ; Huntington’s disease ; Mitochondria - metabolism ; Mitochondria - physiology ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - physiopathology ; Neurodegenerative disorders ; Parkinson Disease - epidemiology ; Parkinson Disease - metabolism ; Parkinson Disease - physiopathology ; Parkinson's disease ; Sex Characteristics ; Sex Factors</subject><ispartof>Neuroscience and biobehavioral reviews, 2019-07, Vol.102, p.95-105</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-455ddb454df035c1f4c244f5165236dc40b68c6a4e0adbad9f1b6220997e17633</citedby><cites>FETCH-LOGICAL-c425t-455ddb454df035c1f4c244f5165236dc40b68c6a4e0adbad9f1b6220997e17633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S014976341830811X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30959072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ullah, Mohammad Fahad</creatorcontrib><creatorcontrib>Ahmad, Aamir</creatorcontrib><creatorcontrib>Bhat, Showket Hussain</creatorcontrib><creatorcontrib>Abu-Duhier, Faisel M.</creatorcontrib><creatorcontrib>Barreto, George E.</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><title>Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>•Neurodegenerative diseases onset and pathology are influenced by gender and genetic mechanisms.•Sex dimorphism occurs in virtually all neurodegenerative diseases.•Mitochondrial functions and epigenetic modifications are mechanisms triggering sex differences in neurodegenerative diseases.
The impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a gender-dependent natural bias of neurodegenerative diseases, such as, Alzheimer's disease, Parkinson's disease, Huntington’s disease and multiple sclerosis, with the ratio of male to female prevalence as well as the severity of the disease differing significantly between the two sexes. This observation has recently garnered much attention and it is now being realized that understanding the sex as a biological variable in the etiology of the neurodegenerative diseases may advance the status of the pathophysiology and treatment strategies while improving the associated decline in cognitive and functional abilities. This review highlights the influence of gender in neurodegenerative disorders and further discusses the sex-specific pre-determined microenvironments that are critical in predisposing the individuals to such disorders.</description><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Cognitive impairment</subject><subject>Epigenesis, Genetic - physiology</subject><subject>Gender bias</subject><subject>Humans</subject><subject>Huntington Disease - epidemiology</subject><subject>Huntington Disease - metabolism</subject><subject>Huntington Disease - physiopathology</subject><subject>Huntington’s disease</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria - physiology</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Neurodegenerative disorders</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAURa0KBMPHX2i9ZJPw7NjJeIlQoUhIbNq15djPjEeZOLUzo86Sf45HQ9my8ubce_0OIT8Y1AxYe7uuR9z2ISbc1RyYqkHUAM03smDLrqk6yZcnZAFMqKprG3FOLnJeAwCHRp6R8waUVNDxBXl72kzGzjR6mvEfdcF7TDhazNSMjr7i6DDRPKENPtgw72kcaY8rsyvjZqB2ZVLJYwp5DvYYmsy8itNqn0Mc4uv-0F1-m6LDUofJzGGHZSnHVLrzFTn1Zsh4_fFekj8PP3_f_6qeXx6f7u-eKyu4nCshpXO9kML5coNlXlguhJeslbxpnRXQt0vbGoFgXG-c8qxvOQelOmTFQXNJbo69U4p_t5hnvQnZ4jCYEeM268K2vGFKyYJ2R9SmmHNCr6cUNibtNQN98K_X-tO_PvjXIHTxX5LfP0a2_QbdZ-6_8ALcHQEsp-4CJp1tOPh2IaGdtYvhy5F3hDGexw</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Ullah, Mohammad Fahad</creator><creator>Ahmad, Aamir</creator><creator>Bhat, Showket Hussain</creator><creator>Abu-Duhier, Faisel M.</creator><creator>Barreto, George E.</creator><creator>Ashraf, Ghulam Md</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201907</creationdate><title>Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders</title><author>Ullah, Mohammad Fahad ; 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The impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a gender-dependent natural bias of neurodegenerative diseases, such as, Alzheimer's disease, Parkinson's disease, Huntington’s disease and multiple sclerosis, with the ratio of male to female prevalence as well as the severity of the disease differing significantly between the two sexes. This observation has recently garnered much attention and it is now being realized that understanding the sex as a biological variable in the etiology of the neurodegenerative diseases may advance the status of the pathophysiology and treatment strategies while improving the associated decline in cognitive and functional abilities. This review highlights the influence of gender in neurodegenerative disorders and further discusses the sex-specific pre-determined microenvironments that are critical in predisposing the individuals to such disorders.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>30959072</pmid><doi>10.1016/j.neubiorev.2019.04.003</doi><tpages>11</tpages></addata></record> |
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| subjects | Alzheimer Disease - epidemiology Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Brain - metabolism Brain - physiopathology Cognitive impairment Epigenesis, Genetic - physiology Gender bias Humans Huntington Disease - epidemiology Huntington Disease - metabolism Huntington Disease - physiopathology Huntington’s disease Mitochondria - metabolism Mitochondria - physiology Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - metabolism Multiple Sclerosis - physiopathology Neurodegenerative disorders Parkinson Disease - epidemiology Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson's disease Sex Characteristics Sex Factors |
| title | Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders |
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