Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation
Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop...
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| Veröffentlicht in: | Mayo Clinic proceedings 2019-05, Vol.94 (5), p.864-874 |
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| creator | Holmes, David R. Alkhouli, Mohamad Reddy, Vivek |
| description | Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion. |
| doi_str_mv | 10.1016/j.mayocp.2018.09.025 |
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However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. 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All rights reserved.</rights><rights>COPYRIGHT 2019 Frontline Medical Communications Inc.</rights><rights>Copyright Mayo Foundation for Medical Education and Research May 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-68c2fa9135e6517e0371d9c77c2777389c2e03fb43395eec167ae18d9acc81f23</citedby><cites>FETCH-LOGICAL-c506t-68c2fa9135e6517e0371d9c77c2777389c2e03fb43395eec167ae18d9acc81f23</cites><orcidid>0000-0003-3847-0959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30962008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes, David R.</creatorcontrib><creatorcontrib>Alkhouli, Mohamad</creatorcontrib><creatorcontrib>Reddy, Vivek</creatorcontrib><title>Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. 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This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion.</description><subject>Anticoagulants</subject><subject>Apixaban</subject><subject>Atrial fibrillation</subject><subject>Blood clots</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>Catheters</subject><subject>Clopidogrel</subject><subject>Diabetes</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Fibrillation</subject><subject>Heart failure</subject><subject>Heart surgery</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Methods</subject><subject>Mortality</subject><subject>Occlusion</subject><subject>Patients</subject><subject>Prevention</subject><subject>Rivaroxaban</subject><subject>Stroke</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Warfarin</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kVFrFDEUhYModlv9ByIBQXyZMcnMZCYvwrLYKiytYPscspk73ayZZEwyC_33ZthW1AfJw4XDd24O9yD0hpKSEso_HspRPXg9lYzQriSiJKx5hlZU1Kxompo_RyuSpYJTwc_QeYwHQkgrRP0SnVVEcEZIt0JpC0PC6xSMsng9TeB6dQ_4Rms7R-MdHnzAt3vAd26EhDfWOKMzeg3QR-wH_D0F_wPwtwBHcGlxGIevvTsqe5ytCk-7L80uGGvVgrxCLwZlI7x-nBfo7vLz7eZLsb25-rpZbwvdEJ4K3mk2KEGrBnhDWyBVS3uh21aztm2rTmiWtWFXV5VoADTlrQLa9UJp3dGBVRfow2nvFPzPGWKSo4kacgoHfo6SMcIZ4w2pMvruH_Tg5-Byukwx1olGtHWmyhN1ryxI4wafgtL59TAa7R0MJuvrphOUcd6JbHj_h2EPyqZ99HZerhD_BusTqIOPMcAgp2BGFR4kJXLpWx7kqW-59C2JkLncbHv7GHvejdD_Nj0VnIFPJwDynY8GgozagNPQmwA6yd6b___wCzycvE4</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Holmes, David R.</creator><creator>Alkhouli, Mohamad</creator><creator>Reddy, Vivek</creator><general>Elsevier Inc</general><general>Frontline Medical Communications Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3847-0959</orcidid></search><sort><creationdate>201905</creationdate><title>Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation</title><author>Holmes, David R. ; 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| subjects | Anticoagulants Apixaban Atrial fibrillation Blood clots Cardiac arrhythmia Care and treatment Catheters Clopidogrel Diabetes Doppler effect Echocardiography Fibrillation Heart failure Heart surgery Hypertension Ischemia Methods Mortality Occlusion Patients Prevention Rivaroxaban Stroke Thromboembolism Thrombosis Warfarin |
| title | Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation |
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