Galectin‐3 aggravates ox‐LDL‐induced endothelial dysfunction through LOX‐1 mediated signaling pathway

Galectin‐3, a biomarker linking oxidative stress and inflammation, participates in different mechanisms related to atherothrombosis, such as inflammation, proliferation, or macrophage chemotaxis. Accumulating evidence indicates that galectin‐3 may also promote atherogenesis through inducing endothel...

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Veröffentlicht in:	Environmental toxicology 2019-07, Vol.34 (7), p.825-835
Hauptverfasser:	Ou, Hsiu‐Chung, Chou, Wan‐Ching, Hung, Ching‐Hsia, Chu, Pei‐Ming, Hsieh, Pei‐Ling, Chan, Shih‐Hung, Tsai, Kun‐Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Antibodies Atherogenesis Atherosclerosis - chemically induced Atherosclerosis - metabolism Atherosclerosis - pathology Biomarkers Cells, Cultured Chemotaxis Cytotoxicity Drug Synergism Endothelial cells Endothelium, Vascular - drug effects Galectin 3 - pharmacology galectin‐3 Gene expression Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - physiology Humans Incubation period Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Kinases Lipoproteins Lipoproteins, LDL - toxicity Liquid oxygen Low density lipoprotein LOX‐1 Macrophages Monocytes NAD(P)H oxidase NADPH oxidase NADPH-diaphorase NF-kappa B - metabolism Nicotinamide Nicotinamide adenine dinucleotide Nucleic acids Oxidase Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases - metabolism Phosphates Pretreatment Proliferation Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Receptor density Receptors RNA Scavenger Receptors, Class E - physiology Signal transduction Signal Transduction - drug effects Signaling THP-1 Cells Toxicity Umbilical vein Uptake
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